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Implementation of Modern Incisional Hernia Repair Techniques

Incisional hernia is one of the most common complications (5–20%) after abdominal surgery. Surgery is the only option to cure a hernia. Symptoms of an incisional hernia depend on the size of the abdominal wall defect and the protruding tissue. About 30% of the patients with an incisional hernia will have an operation performed. Traditional surgical sutured techniques have very high recurrence rate

Impact of site-specific conjugation strategies on the pharmacokinetics of antibody conjugated radiotherapeutics

Antibody radionuclide conjugates are an emerging modality for targeted imaging and potent therapy of disseminated disease. Coupling of radionuclides to monoclonal antibodies (mAbs) is typically achieved by applying non-site-specific labelling techniques. With the ambition of reducing variability, increasing labelling efficacy and stability, several site-specific conjugation strategies have been de

Antibacterial Fusion Proteins Enhance Moraxella catarrhalis Killing

Moraxella catarrhalis is a human-specific commensal of the respiratory tract and an opportunistic pathogen. It is one of the leading cause of otitis media in children and of acute exacerbations in patients with chronic obstructive pulmonary disease, resulting in significant morbidity and economic burden. Vaccines and new immunotherapeutic strategies to treat this emerging pathogen are needed. Comp

The once “eternally living” Lenin is still dead. Really?

Monuments to Joseph Stalin and Felix Dzerzhinsky are constantly increasing in contemporary Russia. However, new monuments to Lenin are no longer being built. From the perspective of today’s strongmen, Stalin and Dzerzhinsky represent strength, war victory and domestic “iron order”. Lenin, on the other hand, is seen as a political adventurer and destabilizer. As a man who, according to Vladimir Put

Homozygosity for the IgG2 subclass allotype G2M(n) protects against severe infection in hereditary C2 deficiency

Homozygous C2 deficiency (C2D) is the most common deficiency of the classical complement pathway in Western countries. It is mostly found in patients with autoimmune disease or susceptibility to bacterial infections and in healthy persons. We wished to assess to what extent other immunological factors might explain differences of susceptibility to infections in C2D. For this reason, 44 Swedish pat

Attitudes and beliefs regarding umbilical cord clamping among midwives, obstetricians, and neonatologists in Sweden: A national cross-sectional survey

ObjectiveThe study aimed to explore attitudes and beliefs among midwives, obstetricians, and neonatologists regarding umbilical cord clamping practices, including scenarios involving neonatal compromise. The study was conducted in the context of exploring the potential for implementing intact cord resuscitation.Study designA national cross-sectional survey was administered electronically, using anObjectiveThe study aimed to explore attitudes and beliefs among midwives, obstetricians, and neonatologists regarding umbilical cord clamping practices, including scenarios involving neonatal compromise. The study was conducted in the context of exploring the potential for implementing intact cord resuscitation.Study designA national cross-sectional survey was administered electronically, using an