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Surface properties of tetra(ethylene oxide) dodecyl amide compared with poly(ethylene oxide) surfactants. 1. Effect of the headgroup on adsorption

The surfactant tetra(ethylene oxide) n-dodecyl amide (TEDAd) was compared with the poly(ethylene oxide) n-alkyl ethers C12E5, C10E5, and C12E4. The adsorption to hydrophobic liquid-vapor and solid-liquid interfaces, as well as the wetting behavior on a hydrophobic surface, was investigated. The amide group is more hydrophilic than the ethylene oxide group, raising the cloud point and critical mice

Endothelium-dependent relaxation after short-term preservation of vascular grafts

As the integrity of graft endothelium seems to be essential to successful long-term patency in coronary operations, its preservation demands the utmost care. The aim of the present study was to investigate the effects of currently used solutions on endothelium-dependent relaxation after short-term storage of vessels at room temperature or at 4 degrees C. The infrarenal rat aorta was selected for s

Caspase-mediated death of newly formed neurons in the adult rat dentate gyrus following status epilepticus

A large proportion of cells that proliferate in the adult dentate gyrus under normal conditions or in response to brain insults exhibit only short-term survival. Here, we sought to determine which cell death pathways are involved in the degeneration of newly formed neurons in the rat dentate gyrus following 2 h of electrically induced status epilepticus. We investigated the role of three families

Understanding Suicidality: Suicide risk, sex differences and views of suicide attempters

Popular Abstract in Swedish I Sverige inträffar varje år c:a 1 500 självmord och minst 15 000 självmordsförsök. Självmordsbeteende är således ett problem som berör många människor i vårt samhälle. En grupp som löper en klart förhöjd risk att begå självmord är de personer som gjort självmordsförsök. "Självmordsförsökare" utgör dock en heterogen grupp av människor av olika ålder, kön, sociala omstänBetter understanding of suicidality may improve treatment and care of suicide attempters. This thesis aims at understanding suicidality by investigating suicide risk, sex differences and views of suicide attempters. Suicide risk factors (prospectively determined) differed between the sexes: Older age and high suicidal intent were female risk factors, whereas previous attempts and using a violent

Genetic intratumour heterogeneity in high-grade brain tumours is associated with telomere-dependent mitotic instability.

Glioblastoma multiforme (GBM) and other high-grade brain tumours are typically characterized by complex chromosome abnormalities and extensive intratumour cytogenetic heterogeneity. The mechanisms behind this diversity have been little explored. In this study, we analysed the pattern of chromosome segregation at mitosis in 20 brain tumours. We found an abnormal segregation of chromatids at mitosis

DNA interaction with catanionic vesicles

DNA-cationic liposome complexes as possible vehicles for gene delivery is currently an important issue. In this work, the interaction between DNA and thermodynamically stable, spontaneously formed, catanionic vesicles with a net positive charge is studied. A phase map was drawn for the aqueous system of DNA and positively charged vesicles, composed of CTAB (cetyltrimethylammonium bromide) and SOS

Prussian blue modified glassy carbon electrodes - Study on operational stability and its application as a sucrose biosensor

Stabilisation of electrochemically deposited Prussian blue (PB) films on glassy carbon (GC) electrodes has been investigated and an enhancement in the stability of the PB films is reported if the electrodes are treated with tetrabutyl ammonium toluene-4-sulfonate (TTS) in the electrochemical activation step following the electrodeposition. A multi-enzyme PB based biosensor for sucrose detection wa

On the interaction between adsorbed layers of monoolein and the lipase action on the formed layers

We used the Surface Force Apparatus (SFA) and ellipsometry techniques to study the interaction forces and the adsorption behavior of monoolein (MO), respectively. MO was adsorbed from water to a hydrophobised mica or silica surface. In addition the effect of added lipase, Thermomyces (Humicula) lanuginosa lipase (TLL), to an adsorbed layer of MO was investigated. The force versus distance curves b

Size-Resolved Respiratory Tract Deposition of Fine and Ultrafine Hydrophobic and Hygroscopic Aerosol Particles during Rest and Exercise

Airborne ultrafine particles (diameter <100 nm) are ubiquitous in the environment and have been associated with adverse health effects. The respiratory-tract deposition of these particles is fundamentally influenced by their hygroscopicity: their ability to grow by condensation of water in the humid respiratory system. Ambient particles are typically hygroscopic, to varying degrees. This article i

Fruit and vegetable consumption in relation to risk factors for cancer: a report from the Malmo Diet and Cancer Study

OBJECTIVE: To examine the associations between the consumption of fruit and vegetables and other markers of cancer risk. DESIGN: A cross-sectional survey within the population-based prospective Malmo Diet and Cancer (MDC) Study. Information on food habits was collected through the modified diet history method designed and validated for the MDC Study. Data on smoking and alcohol habits, leisure tim

Consequences of organic farming and landscape heterogeneity for species richness and abundance of farmland birds.

It has been suggested that organic farming may benefit farmland biodiversity more in landscapes that have lost a significant part of its former landscape heterogeneity. We tested this hypothesis by comparing bird species richness and abundance during the breeding season in organic and conventional farms, matched to eliminate all differences not directly linked to the farming practice, situated in

Correlation between blood glucose concentration and glucose concentration in subcutaneous adipose tissue evaluated with microdialysis during intensive care

Background: Hyper- as well as hypoglycemia may be detrimental for brain energy metabolism and even a moderate increase in blood glucose concentration can affect outcome adversely. During physiological conditions, glucose concentration obtained from microdialysis of subcutaneous adipose tissue adequately reflects plasma glucose concentration. This study examines whether this correlation is also obt

Improved DNA flow cytometric, DNA ploidy, and S-phase reproducibility between 15 laboratories in analysis of breast cancer using generalized guidelines

Background: Lack of generalized guidelines for DNA flow cytometric analysis (FCM) may be the main reason for its limited use in the clinical management of breast cancer. Methods: After an initial interlaboratory reproducibility study (Round 1), we concluded that it was the evaluation of the DNA histograms rather than the technical performance of the analysis that was the main reason for discordant

Comparison of Endorette and dilatation and curettage for sampling of the endometrium in women with postmenopausal bleeding

MAIN QUESTION: To compare the diagnostic properties of Endorette and D&C in women with postmenopausal bleeding, to relate the properties to endometrial thickness as measured by ultrasound, and to assess the women's experiences of the two methods. METHODS: In a prospective study, 133 consecutive women with postmenopausal bleeding were examined with transvaginal ultrasound. After measuring the e

Probing the functional role of the N-terminal region of cystatins by equilibrium and kinetic studies of the binding of Gly-11 variants of recombinant human cystatin C to target proteinases

The interaction between cystatin C variants, in which the evolutionarily conserved Gly-11 residue was substituted by Ala, Glu or Trp, and the cysteine proteinases, papain, ficin, actinidin and cathepsin B, was characterized. The substitutions reduced the affinity of binding in a manner consistent with the Gly residue of the wild-type inhibitor, allowing the N-terminal region to adopt a conformatio

Man hittar sin nisch. Om män i socionomyrket - karriär, minoritet och maskulinitet

This dissertation is about men as a minority in a female profession, that of university- trained social worker. The aim is to illuminate the relationship between work and gender on the basis of career, minority, and masculinity in the profession of social work. By means of questionnaires sent to all the men who trained as social workers in Lund 1980–1985 (the 1980s generation) and 1993–2003 (the 1

The role of the leukemia-associated ETO homologue repressors in hematopoiesis

Popular Abstract in Swedish Blodet fyller livsviktiga uppgifter i kroppen såsom syretransport och infektionsförsvar. De röda blodkropparna sköter syretransporten och de vita blodkropparna hanterar infektionsskyddet eller immunförsvaret. Blodplättar står för blodets levring vid blödning. Efterhand förbrukas blodcellerna och därför sker en kontinuerlig nybildning. Vid akut behov kan produktionen av The fusion protein AML1-ETO is observed in acute myeloid patients with the chromosomal translocation t(8;21). Cells with this chimeric protein have impaired granulocytic and erythroid differentiation with accumulation of myeloblasts. The transcriptional co-repressor ETO (Eight Twenty One) was identified from the cloning of AML1-ETO. Subsequently, MTGR1 (Myeloid Translocation Gene-Related protein 1

Observer reliability of industrial activity analysis based on video recordings

The aim of this study was to assess the agreement between observers analyzing activity patterns during truck engine assembly work based on video recordings. Two observers observed the recordings of nine workers, on the average 2.2 h long, assigning activities to four activity categories. For each activity category data were obtained on the mean duration of uninterrupted sequences of activities and

Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake

Protein kinase B (PKB)/Akt has been strongly implicated in the insulin-dependent stimulation of GLUT4 translocation and glucose transport in skeletal muscle and fat cells. Recently an allosteric inhibitor of PKB (Akti) that selectively targets PKB alpha and -beta was reported, but as yet its precise mechanism of action or ability to suppress key insulin-regulated events such as glucose and amino a

Carotenoid S(1) state in a recombinant light-harvesting complex of Photosystem II.

The carotenoid species lutein, violaxanthin, and zeaxanthin are crucial in the xanthophyll-dependent nonphotochemical quenching occurring in photosynthetic systems of higher plants, since they are involved in dissipation of excess energy and thus protect the photosynthetic machinery from irreversible inhibition. Nonetheless, important properties of the xanthophyll cycle carotenoids, such as the en