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Background: Particle exposure is a risk factor for cardiovascular diseases. Mitochondrial DNA (mtDNA) is a primary target for oxidative stress generated by particle exposure. We aimed to elucidate the effects of occupational exposure to particle-containing welding fumes on different biomarkers of mtDNA function, and in turn, explore if they modify the association between particle exposure and card
Objective: To study selective regional binding for tau pathology in vivo, using PET with [11C]PBB3 ([11C]methylamino pyridin-3-yl buta-1,3-dienyl benzo[d]thiazol-6-ol) in tauopathies, and in conditions not typically associated with tauopathy. Background: Tau imaging is a promising tool to study the link between tau and neurodegeneration. The specificity of tracers in vivo however remains uncertain
BACKGROUND: Increased somatostatin plasma concentration has been found in patients with vascular dementia. However, it is unknown whether or not somatostatin levels may predict dementia development in the general population. To this end, we sought to assess the association of circulating N-terminal prosomatostatin (NT-proSST) with incident dementia among community-dwelling older adults.METHODS: In
Soil bulk density (BD) is a parameter dependent on soil texture, compositions of soil minerals and organic matter and the extent of soil compaction. Seasonal freeze/thaw in arid areas with shallow groundwater tables (AASGT) may significantly change BD and hence soil hydrothermal properties and water holding capacity. Therefore, quantifying soil bulk density changes (BDC) under freeze/thaw conditio
PACs (polycylic aromatic compounds) are air pollutants formed in incomplete combustion, e.g., in vehicle engines. Vegetation can potentially remove substantial amounts and act as bioindicators of these pollutants. Increased knowledge of the pollutant removal efficiencies of different tree species is essential for understanding the potential benefits trees can provide urban residents. We investigat
Nondisplaced or minimally displaced femoral neck fractures are commonly treated with internal fixation, because of its less invasive and less time-consuming nature, as well its retention of the biological properties of the hip. Internal fixation with screws or pins is the current clinical routine in Sweden. However, the authors of some recent studies in elderly patients have suggested that the use
Aims/hypothesis: Monogenic forms of diabetes (MODY, neonatal diabetes mellitus and syndromic forms) are rare, and affected individuals may be misclassified and treated suboptimally. The prevalence of type 1 diabetes is high in Finnish children but systematic screening for monogenic diabetes has not been conducted. We assessed the prevalence and clinical manifestations of monogenic diabetes in chil
Background: Diet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: This analysis includes 1,886 incident endometrial ca
Det här avhandlingsprojektet handlar om självmedvetande och hur det förhåller sig till medvetande i stort. Mer specifikt handlar det om jagupplevelse, känslan av att vara ett jag, och om denna känsla med nödvändighet finns med i alla våra upplevelser eller inte. Vad betyder det då att ha en känsla av att vara ett jag? Det kan betyda flera saker, exempelvis känslan av att vara samma person över tidThe present dissertation project concerns the relationship between self and consciousness. Specifically, it concerns the phenomenal sense of self and if this is a necessary component of all experience or not. What is it to have a sense of self? This can refer to several things, such as the sense of being a continuous person through time, the sense of having a body, the sense of being in control of
This thesis explores how older people construct meaning, use and make sense of three kinds of robots in their homes. The exploration is undertaken in empirical studies of an assistive robot, an eHealth system, and robotic vacuum cleaners. The research draws on data collected through interviews and observations of older people in relation to three robots. The results show that older people’s domest
Background Trauma is the leading cause of quality-related mortality in low- and middle-income countries, with an estimated two million preventable deaths each year. Although trauma quality improvement programmes have been utilised in high-income countries for more than three decades, there is no high-level evidence of their effect on patient outcomes. We aimed to assess whether implementing a cont
People with intellectual disabilities have an increased risk of diabetes mellitus (DM). They tend to develop it at earlier ages than the general population, resulting in even higher risks in younger people. However, few studies have separated Type 1 and Type 2 DM. The aim of this study was to assess prevalence of different types of DM in different age groups in relation to the general population.
BackgroundAmbulance clinicians increasingly refer patients to self-care, positioning ambulance service within a wider gatekeeping role and necessitating the assessment of whether self-care is a safe option or if further support is needed. Contrary to primary healthcare centre (PHC) referrals, self-care referrals often lack structured follow-ups, with the decision consequences remaining underexplor
Background: The C-reactive protein-triglyceride-glucose index (CTI) has been proposed as a novel biomarker for insulin resistance and inflammation. However, its role in the progression trajectory of cardiometabolic multimorbidity (CMM) remains unclear. We aimed to investigate the involvement of the CTI in the CMM progression trajectory. Methods: This prospective study included 266,049 individuals
Populärvetenskaplig sammanfattning: Kvävekoncentrationen i den gröna biomassan hos vegetation är involverad i många olika biokemiska processer i det terrestra ekosystemet. Till exempel så påverkar den fotosyntesen, förmultning och evaportanspirationen, för att nämna några. Därför är den också ofta en av grundparametrarna och drivkraften i olika ekosystem-modeller. Att mäta kvävehalten hos blad/barNitrogen in the green biomass of vegetation plays an important role in many biochemical processes in the terrestrial ecosystems, and often used as an input parameter to ecosystem models. It strongly influences photosynthetic rate, decomposition, and evaportanspiration, to name a few. Measuring nitrogen in field involves a lot of time and money, and it would be valuable if this part of the data col
Physical exhaustion can constrain stair ascending capacity during emergency evacuation. The overall aim of this research was to explore and compare stair ascending capacities and physiological limitations when using two different modes: 1) self-preferred pace on three different public stairways, and 2) four machine-controlled paces on a stair machine corresponding to different percentages of maxim
Background/Aims: Prospective data on age-related changes in kidney function are required, especially since the current Kidney Disease Improving Global Outcomes (KDIGO) definition has been suggested to classify a large number of elderly people with CKD. Objective: This study, a complement to our previous Cr-based study in the same cohort, is aimed at evaluating cystatin C (cysC)-based changes in ki
Background: As the deadline for the Sustainable Development Goals approaches, financial protection in Cambodia remains inadequate, especially for nonpoor informal workers lacking formal social health protection coverage or access to other prepayment schemes. This exposes them to high out-of-pocket health expenditures (OOPE) and related financial hardship. To better understand the drivers behind th
Objective. Prior incidence estimates of psoriatic arthritis (PsA) vary considerably. We aimed to assess the annual incidence of clinically diagnosed PsA among adults in Sweden in 2014-2016, overall and stratified by age/sex/education/geography, and to investigate potential time trends in incidence in 2006-2018. Use of disease-modifying antirheumatic drugs (DMARDs) during the 2 years after diagnosi
In the plant-based beverage industry, a residue called okara, is generated in large quantities in the liquid-solid separation step. Despite the high nutritional value of okara from soy and oat beverages with respect to fiber and protein content, these residues are generally discarded or used as animal feed or compost. It would be more sustainable to utilize okara for human consumption, however, th
