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During the prolonged course of chronic viral infection there is a continuous reciprocal interaction between the host immune defence system and the viral immunogens, and viral genetic mutations capable of circumventing host immune defence could be selected for. Our observation of increasing prevalence of heterogeneity in the DNA sequence coding for the ‘a1 determinant of HBsAg in patients with pres
Johannes Magnus (1488–1544) was the last Catholic archbishop of Uppsala to hold residence in Sweden. He was also a historian and wrote a work in Latin about Swedish history that was to gain an unparalleled importance. The work is entitled Historia de omnibus Gothorum Sueonumque regibus, the ‘History of all the Kings of the Goths and the Swedes’. It is arranged as a series of biographies of over 20
BACKGROUND AND OBJECTIVES: Human genetic studies support a key role of interleukin-6 (IL-6) in the pathogenesis of ischemic stroke. Still, there are only limited data from observational studies exploring circulating IL-6 levels as a risk factor for ischemic stroke. Here, we set out to perform a systematic review and meta-analysis of aggregate data on cohort studies to determine the magnitude and s
Background and aims: PPARGC1A encodes PGC-1α (peroxisome proliferator-activated receptor γ coactivator 1-α), a central regulator of energy metabolism and mitochondrial function. A common polymorphism in PPARGC1A (rs8192678, C/T, Gly482Ser) has been associated with obesity and related metabolic disorders, but no published functional studies have investigated direct allele-specific effects in adipoc
Syftet med den här uppsatsen är att ur ett civilrättsligt perspektiv undersöka hur de svenska civilrättsliga reglerna skyddar någon som riskerar att utsättas för barn- och tvångsäktenskap, samt olika myndigheters agerande och förhållningssätt när de möter någon som befinner sig i riskzonen för påtvingade äktenskap. En stor del av de äktenskap som ingås mot någons vilja berör parter som bor i oliThe purpose of this paper is to examine from a civil law perspective how the Swedish legislation protect anyone at risk for child and forced marriages, as well as how various government agencies intervene and approach situations when they meet someone who is at risk of forced marriage. A large part of the marriage entered against someone's will affect parties who live in different countries.
The book is a part of the result of a project, funded by HSFR (The Swedish Council for Research in the Humanities and Social Sciences). In general it comprises the art criticism in the Swedish daily press from 1990-2000. The studies have a common focus on the text of the art criticism, in contrast to older research on art criticism, which uses the text primarily as a source of knowledge about the
Alcohol and tobacco consumption are closely correlated and published results on their association with breast cancer have not always allowed adequately for confounding between these exposures. Over 80% of the relevant information worldwide on alcohol and tobacco consumption and breast cancer were collated, checked and analysed centrally. Analyses included 58515 women with invasive breast cancer an
Adduct formation between cationic reagents and targets on DNA are facilitated by the ability of DNA to attract cations to its surface. The electrostatic interactions likely provide the basis for the documented preference exhibited by cisplatin and related compounds for nuclear DNA over other cellular constituents. As an extension of a previous communication, we here present an investigation illust
Background: The pathophysiology of neurodegeneration is complex. Its diagnosis requires an early identification of sequential changes in several hallmarks in the brains of affected subjects. The presence of brain pathology can be visualized in the cerebrospinal fluid (CSF) by protein profiling. It is clear that the field of Alzheimer’s disease (AD) will benefit from an integration of algorithms in
Inom beredskapen mot radiologiska och nukleära olyckor och katastrofer spelar strålningsmätningar en avgörande roll för att ta reda på vad som har hänt och hur farligt det är för människa, djur och natur och på vilket sätt det påverkar miljö och samhällsfunktioner. I Sverige och många andra länder i världen har allmänheten en rättighet att få reda på vad som hänt och vad de utsätts för i ett eventThis thesis describes investigations made on mobile and stationary gammaspectrometry made both under laboratory conditions and in situ. The objective hasbeen to identify and quantify radionuclides in the form of point sources,contamination and widespread deposition in situations where the measurementgeometry is not known beforehand. Both scintillators and semiconductor detectors ofsimilar size wer
Agricultural intensification and associated loss of high-quality habitats are key drivers of insect pollinator declines. With the aim of decreasing the environmental impact of agriculture, the 2014 EU Common Agricultural Policy (CAP) defined a set of habitat and landscape features (Ecological Focus Areas: EFAs) farmers could select from as a requirement to receive basic farm payments. To inform th
Importance: The diagnostic performance of second-generation tau positron emission tomographic (PET) tracers is not yet known. Objective: To examine the novel tau PET tracer RO948 F 18 ([18F]RO948) performance in discriminating Alzheimer disease (AD) from non-AD neurodegenerative disorders. Design, Setting, and Participants: In this diagnostic study, 613 participants in the Swedish BioFINDER-2 stud
Background: Prediction of neurological outcome in unconscious patients after cardiac arrest (CA) forms the basis for decisions on further level-of-care based on results from clinical neurological examinations, neuroimaging (CT or MRI), neurophysiology (EEG or SSEP) and blood biomarkers of brain injury. Methods must be highly specific to avoid misclassifying patients with possibilities of a good ou
It is of great interest and importance how different amino acid residues contribute to and affect the properties of a protein surface, Partitioning in aqueous two-phase systems has the potential to be used as a rapid and simple method for studying the surface properties of proteins. The influence on partitioning of the surface exposed amino acid residues of eight structurally determined monomeric
Popular Abstract in Swedish I Män, våld och moralarbete uppmärksammas hur män, som frivilligt sökt sig till verksamheter där det erbjuds behandling för våld i nära relationer, rapporterar om sina erfarenheter. Rapporteringarna består dels av svar på frågeformulär, dels genom deltagande i samtalsintervjuer. Författaren analyserar hur männen förklarar sina handlingar och gestaltar återberättade erfaMen, violence and moral work- Reports from help-seeking men at treatment centers working with violence in close relationships Men’s violence against women is an extensive social problem. In the 1970s, a new kind of centers were established in the US and UK, focusing on treating men who had been violent against their wives or girlfriends, the aim which is to end the men’s violent behavior. In the
ABSTRACT: BACKGROUND: Urothelial carcinoma (UC) is characterized by nonrandom chromosomal aberrations, varying from one or a few changes in early-stage and low-grade tumors, to highly rearranged karyotypes in muscle-invasive lesions. Recent array-CGH analyses have shed further light on the genomic changes underlying the neoplastic development of UC, and have facilitated the molecular delineation a
Popular Abstract in Swedish De fyra essäerna i Sickness Insurance: Design and Behavior studerar sjukförsäkringens utformning ur både ett empiriskt och ett teoretiskt perspektiv. Den första essän bygger på en enkätstudie och innehåller två delar. I den första delen undersöks människors preferenser för olika utformningar av sjukförsäkringen, där de olika utformningarna förväntas ge ungefär samma kosThe first essay presents the results from a questionnaire study of sickness insurance and sickness absence behavior in Sweden. In the first part, people’s preferences for the design of a sickness insurance are discussed. Three combinations of qualifying days and compensation rates, with approximately the same costs within the insurance system, are compared. From the questionnaire it is concluded t
Achieving robust and efficient control of internal combustion engines is critical for meeting stringent environmental regulations and reducing greenhouse gas emissions. Natural gas engines, in particular, offer significant potential for cleaner energy but present unique challenges due to variations in fuel composition and combustion dynamics.This thesis investigates novel methods for improving com
Background: Individuals’ perception of their work climate is expected to strongly influence personnel’s organizational commitment. However, the evidence about the association between organizational commitment and important outcomes, such as performance at work and turnover, is mixed. If this was not enough, little attention has been paid to how individual differences in basic personality (e.g., in
We present the first data release of VELOcities of CEpheids (VELOCE), dedicated to measuring the high-precision radial velocities (RVs) of Galactic classical Cepheids (henceforth, Cepheids). The first data release (VELOCE DR1) comprises 18 225 RV measurements of 258 bona fide classical Cepheids on both hemispheres collected mainly between 2010 and 2022, along with 1161 observations of 164 stars, m
