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Accelerated by the harms and depletion risk of fossil fuels, transition to low-carbon or renewable fuels have become an urgent need for combustion engines to decarbonize transport sectors. Natural gas-diesel dual-fuel combustion is a promising method to achieve these goals by allowing the usage of natural gas in diesel engines. However, this concept has drawbacks of low combustion efficiency, high

Background: Intra- and interfractional variations in anatomy can cause unplanned substantial alterations of the dose distribution of the target in proton therapy. Motion management methods might be used in order to minimize anatomical variations. In the proton therapy of lung cancer, a potential motion management technique is the use of the voluntary breath-hold approach. The aim of this study was

Clouds are essential elements within Earth's atmosphere, posing a challenge for cloud-resolving models in understanding the creation of new cloud ice particles from existing ice and liquid phases. Such ice initiation determines cloud microphysical and radiative properties, influencing cloud phase, precipitation and cloud extent/properties. To address this challenge effectively, it proves beneficia

BACKGROUND: Analyses of clinical outcomes following radiotherapy (RT) have advanced our understanding of fundamental radiobiological characteristics in head and neck squamous cell carcinoma (HNSCC). Low fractionation sensitivity appears to be a common feature, as well as susceptibility to changes in overall treatment time (OTT). Large tumors should be harder to cure if a successful RT requires the

Background: Moderate-to-severe hemophilia B is treated with lifelong, continuous coagulation factor IX replacement to prevent bleeding. Gene therapy for hemophilia B aims to establish sustained factor IX activity, thereby protecting against bleeding without burdensome factor IX replacement. Methods: In this open-label, phase 3 study, after a lead-in period (≥6 months) of factor IX prophylaxis, we

BACKGROUND: Cleaning workers are exposed to chemicals and high physical workload, commonly resulting in airway problems and pain. In this study the response in the upper airways and the physical workload following airborne and ergonomic exposure of cleaning spray was investigated.METHODS: A survey was answered by professional cleaning workers to investigate their use of cleaning sprays and the per

PURPOSE: The aim of this study was to compare outcomes of single or multistage approach during fenestrated-branched endovascular aortic repair (FB-EVAR) of extensive thoracoabdominal aortic aneurysms (TAAAs).METHODS: We reviewed the clinical data of consecutive patients treated by FB-EVAR for Extent I-III TAAAs in 24 centers (2006-2021). All patients received a single brand manufactured patient-sp

Background: Accumulation of saturated fatty acids (SFAs) in the liver is known to induce hepatic steatosis and inflammation causing non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Although SFAs have been shown to affect the epigenome in whole blood, pancreatic islets, and adipose tissue in humans, and genome-wide DNA methylation studies have linked epigenetic ch

Accurate determination of the genetic diversity present in the HIV quasispecies is critical for the development of a preventative vaccine: in particular, little is known about viral genetic diversity for the second type of HIV, HIV-2. A better understanding of HIV-2 biology is relevant to the HIV vaccine field because a substantial proportion of infected people experience long-term viral control,

When did the Reformation end? Reformation, confessionalization and the representation of Martin Luther in Swedish 16th-century printIn the past decades, Swedish scholars have used the concept of the Reformation to refer to a long process of religious change in Sweden between 1527 and 1593. The influence from the term ”the long reformation” used in the Anglo-Saxon world is tangible. Instead, this e

Background: Tyrosine kinase inhibitors (TKIs) have improved the survival of patients with chronic myeloid leukaemia. Many patients have deep molecular responses, a prerequisite for TKI therapy discontinuation. We aimed to define precise conditions for stopping treatment. Methods: In this prospective, non-randomised trial, we enrolled patients with chronic myeloid leukaemia at 61 European centres i

Aim/Purpose The goal of this paper is to examine digital applications used in Swedish schools and whether they fulfill their potential as support for learners. This is done by examining the kinds of feedback they provide and discussing if this feedback supports learning or not. Background The paper targets one aspect regarding which educational apps can be of high value for learners and teachers,

Background. Knowledge on the globally outstanding Amazonian biodiversity and its environmental determinants stems almost exclusively from aboveground organisms, notably plants. In contrast, the environmental factors and habitat preferences that drive diversity patterns for micro-organisms in the ground remain elusive, despite the fact that micro-organisms constitute the overwhelming majority of li

Hematopoietic stem cells (HSCs) are primitive tissue-specific somatic stem cells, responsible for the maintenance and replenishment of the bone marrow (BM) and subsequently the entire blood system. The never-ending ability to differentiate into all the mature hematopoietic lineages makes these HSCs attractive candidates for use in future regenerative medicine. HSCs are balanced between different f

Service screening with mammography was implemented in Sweden in the late 80's, following the results from trials in Sweden and abroad. A high rate of attendance, a high diagnostic accuracy and treatment in accordance with established guidelines are key circumstances for an effective screening programme. These factors have to be continuously monitored. One trial was carried out 1976-86 in the city

Background: The pathophysiology of neurodegeneration is complex. Its diagnosis requires an early identification of sequential changes in several hallmarks in the brains of affected subjects. The presence of brain pathology can be visualized in the cerebrospinal fluid (CSF) by protein profiling. It is clear that the field of Alzheimer’s disease (AD) will benefit from an integration of algorithms in

Objective: Subjective cognitive decline (SCD) is associated with an increased risk of Alzheimer's Disease (AD). Early disease processes, such as amyloid-β aggregation measured with quantitative PET, may help to explain the phenotype of SCD. The aim of this study was to investigate whether quantitative amyloid-β load is associated with both self- and informant-reported cognitive complaints and mem

All cellular organisms in aquatic environments are susceptible to virus attack. Viruses are the smallest but most abundant biological entities in freshwaters. This thesis describes interactions between viruses and bacteria in temperate and polar freshwaters with particular emphasis on Arctic and Antarctic aquatic systems. Free virus-like particles in freshwaters are vulnerable and exposed and as p

Background: The benefits of exercise in mild and moderate knee or hip osteoarthritis (OA) are apparent, but the evidence in severe OA is less clear. We recently reported that neuromuscular training was well tolerated and feasible in patients with severe primary hip or knee OA. The aims of this controlled before-and-after study were to compare baseline status to an age-matched population-based refe

Popular Abstract in Swedish Energianvändningen i världen måste minska drastiskt inom en snar framtid för att därmed minska utsläppen av växthusgaser och bromsa klimatförändringarna. Energi och handlande med energikällor har även blivit nationella säkerhetsfrågor. Inom Europeiska Unionen används ungefär 40% av den totala energianvändningen i byggnader, vilket innebär ungefär 36% av det totala koldiThe use of energy is a major global issue both according to climate changes but also in the aspect of national safety tied to the trade with energy sources. Of the total energy use in the member states of the European Union, about 40% is used in residential and commercial buildings. Passive houses are one way to reduce the energy use in buildings and at the same time keep a good indoor comfort. Th