Filetype
Background: Cyclic Cushing's syndrome (cCS) features fluctuating cortisol secretion, often causing diagnostic errors or delays, and possibly poorer outcomes. We aimed to identify unpublished cCS cases to characterise clinical challenges and guide strategies for improving outcomes by characterising cycle patterns, peak frequency, and evaluating complications. Methods: This was a retrospective obser
OBJECTIVE: Diabetes significantly increases the risk for atherosclerotic complications, including coronary artery disease (CAD). Previous studies have suggested that adult-onset diabetes can be classified into five different clinical subtypes, including moderate obesity-related diabetes (MOD). The aim of this study was to investigate the genetic associations between the five diabetes subtypes and
Background: Percutaneous coronary intervention (PCI) is frequently used in the treatment of chronic coronary syndrome (CCS), although its impact on long-term prognosis and symptom relief remains debated. Among patients undergoing revascularisation with PCI, data on clinical outcomes following drug-coated balloon (DCB) based PCI in unselected patient populations is limited, and the comparative effe
Loess–palaeosol sequences (LPS) represent one of the most important continental archives of late Quaternary environmental change in Europe. Establishing reliable chronologies is essential for reconstructing dust dynamics and for correlating regional loess stratigraphies. In this study, we present the first systematically derived mass accumulation rate (MAR) dataset for six key Polish LPS, based on
This study is based on an observation of one of the biggest webcommunitys in Sweden today, called Lunarstorm. My main purpose was to research how young people use this media for talking about drug and alcohol-related subjects. The questions I posed were the following: - In which way do young people talk about drugs and alcohol on Lunarstorm? - What possibilities does Lunarstorm create for these
Conventional cemented carbide is recommended for machining Ti6Al4V. However, polycrystalline diamond (PCD) and polycrystalline cubic boron nitride (pcBN) also show promise. Demands for higher productivity accelerate diffusional dissolution and chemically driven wear mechanisms in these tool materials. This study investigates active wear mechanisms by studying the interactions between Ti6Al4V and P
Aims: We introduce ReSurveyEurope — a new data source of resurveyed vegetation plots in Europe, compiled by a collaborative network of vegetation scientists. We de-scribe the scope of this initiative, provide an overview of currently available data, governance, data contribution rules, and accessibility. In addition, we outline further steps, including potential research questions. Results: ReSurv
Accurate prediction of crack growth and strength in glued timber joints and components can be achieved by using cohesive laws in constitutive models. These laws represent the traction-separation relationship that measures the stress transmitted between crack faces in a cohesive zone, and can be obtained directly from experiments. However, studies on measuring the cohesive laws of wood adhesive bon
PurposeTo investigate long-term effects of intravitreal injections on visual outcome, retinal function and structure in eyes with central retinal vein occlusion (CRVO eyes) and macular oedema and compare with untreated CRVO eyes to determine the long-term effects of anti-vascular endothelial growth factor on photoreceptor cell function.MethodsA retrospective study of 38 eyes from 38 CRVO patients.
Background: Monitoring metabolites of tamoxifen, such as endoxifen, has been suggested as a strategy to ascertain therapeutic effect of tamoxifen therapy, but clinical guidelines are missing. Herein, we aim to investigate the outcome of endoxifen concentrations of low-dose tamoxifen, using change in mammographic breast density as a proxy for therapy response. Methods: In the randomized KARISMA-Tam
Nanocrystalline AlxCoCrFeNi (x = 0, 0.3, 0.6, 1 mol) high-entropy alloys were synthesized by mechanical alloying (MA) and consolidated by spark plasma sintering (SPS). Single-phase face-centered cubic (FCC) structure was achieved with x = 0 and 0.3. Dual-phase body-centered cubic (BCC)/B2 + FCC structure was obtained in x = 0.6 and 1. Complete solid solution was achieved with a significantly reduc
Interest in Jane Austen’s fiction and life has never been greater than today. Her narrative works and worlds live on 200 years after their publication not only through their own popularity, but also through numerous re-presentations in the forms of novels, movies, television series, and fan fictions that keep flourishing from her fictional worlds and characters. Austen’s novels, her settings, and
Objectives: To evaluate whether long-term magnetic resonance imaging (MRI) findings, alone or in combination with prostate-specific antigen (PSA) density or the result of prior surveillance biopsies, could be used to omit biopsies occurring after patients have been on active surveillance (AS) for ≥5 years. Patients and Methods: Analysis of a single-institution AS cohort of patients with Grade Grou
AIMS/HYPOTHESIS: The incidence of type 1 diabetes increased during the pandemic in various countries. SARS-CoV-2 infections may trigger the development of type 1 diabetes, but the evidence is inconclusive. This study aimed to assess trends in type 1 diabetes incidence between 2007 and 2023, and to quantify the association between SARS-CoV-2 infections and the risk for developing type 1 diabetes.ME
Background: Geant4, a Monte Carlo Simulation Toolkit extensively used in bio-medical physics, is in continuous evolution to include newest research findings to improve its accuracy and to respond to the evolving needs of a very diverse user community. In 2014, the G4-Med benchmarking system was born from the effort of the Geant4 Medical Simulation Benchmarking Group, to benchmark and monitor the e
Late radiation-induced kidney toxicity limits molecular radionuclide therapy using radiopharmaceuticals such as 177Lu-octreotate and 177Lu-octreotide. Better kidney protection would allow higher amounts of radiopharmaceutical to be administered. Coadministration of recombinant human alpha-1-microglobulin (rA1M) has been suggested to protect kidneys from exposure from 177Lu-octreotate. Furthermore,
Trelleborg fortresses – the dream architecture of the Viking Age. In 1934, few decades after the idea of the existence of Jomsborg had been critically rejected, a geometric Viking fortress was surprisingly discovered on Zealand, named after the site, a so called Trelleborg fortress. This was followed by the search for more fortresses all over Scandinavia, a search that is still ongoing. Their ramp
Introduction: Dislocation is a major complication of total hip arthroplasty (THA) for femoral neck fractures (FNFs). Dual mobility cups (DMCs) are in clinical practice for patients at risk of dislocation in primary-and revision arthroplasty. This study investigated whether changing routines from conventional THA (cTHA) to DMC for fracture patients at our orthopaedic unit resulted in a reduced disl
The traditional approaches rely solely on temperature measures to assess heat-related health risks; but there is a growing trend towards using bio-meteorological indices for a more comprehensive evaluation. However, the adoption of bio-meteorological indices in developing countries is considerably limited. Therefore, this study compares bio-meteorological index, the maximum Universal Thermal Clima
Research on adolescent sexual orientation has expanded in recent decades, yet little is known about its associations with personality traits during this developmental period. This study examined personality dimensions, as measured by the Junior Temperament and Character Inventory, across adolescent sexual orientation groups (asexual, homosexual, heterosexual, bisexual) in a community-based sample
