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Context Recent reports suggest that rheumatoid arthritis (RA) may be a risk factor for venous thromboembolism (VTE), particularly in conjunction with hospitalization. Using hospitalization data to identify RA and VTE may identify patients when they are at elevated risk for other reasons, obscuring the incompletely understood underlying association between RA and VTE and leading to inappropriate in

1. The effects of varied levels (25-300 mM) of ionic strength on mechanical properties and ATP hydrolysis rate of chemically skinned guinea-pig taenia coli fibres were investigated. 2. The tension development following activation by calcium (pCa 4 8), and relaxation following removal of calcium (pCa 9), were slower in 25 mm compared to 150 mm ionic strength. In fibres activated by thiophosphorylat

Retention patterns in lung tissue (determined by transmission electron microscopy and energy dispersive spectrometry) of chrysotile, tremolite, and crocidolite fibres were analysed in 69 dead asbestos cement workers and 96 referents. There was an accumulation of tremolite with time of employment. Among workers who died within three years of the end of exposure, the 13 with high tremolite concentra

Pheromone communication systems have a reliable signal with a restricted window of amounts and ratios released and perceived. We propose a model based on a Gaussian response profile that allows a quantification of the response peak (location of optimum) and a measure of the peak width (response window). Interpreting the Gaussian curve, fitted by nonlinear regression (NLR), as a standard normal dis

Bai Nuur (41 degrees 38.590'N, 114 degrees 30.922'E, similar to 1346 m a.s.l.) and Ulan Nuur (41 degrees 44.214'N, 115 degrees 05.630'E, similar to 1246 m a.s.l.) are two small lakes situated in the transition zone between semi-humid and semi-arid climate regimes that runs parallel to the present limit of the southeast monsoon along the southeastern Inner Mongolia Plateau in north China. A 215 cm-

This study is based on an analysis of more than 2,300 court cases concerning acts of bestiality and same-sex sexuality in rural and urban Sweden 1880–1950. Other written sources are forensic psychi- atric statements, mental hospital records, material from the Swedish Sex Reform movement, news- papers and scientific journals, and minutes of the Swedish Parliament and its subcommittees. In coope

Calreticulin is a multifunctional protein mainly localized in the endoplasmic reticulum in eukaryotic organisms, except yeasts. The protein comprises three distinct regions: the N-terminal N domain, the C-terminal C domain, and the central P domain, reflecting the functional diversity of calreticulin. The protein has been implicated in over 40 intra- and extracellular processes in mammalian cells,

Popular Abstract in Swedish Selen är ett essentiellt näringsämne som behövs för att upprätthålla flera viktiga funktioner i kroppen, huvudsakligen genom en speciell grupp proteiner som heter selenoproteiner. Det finns minst 25 stycken olika selenoproteiner i människan och flera av dem skyddar kroppen mot oxidation medan vissa andra sköter regleringen av sköldkörtelhormoner. Många selenoproteiners Selenium is a micronutrient that is essential for many important life processes due to the action of the specific selenoproteins containing one or more of the 21st amino acid, selenocysteine. Twenty-five selenoprotein genes have been found in the human genome but the function of many of them is not yet known. Some of the characterised selenoproteins have, however, antioxidant properties. Selenium

The enzyme ferrochelatase (EC 4.99.1.1) is the terminal enzyme in the biosynthetic pathway of heme b and catalyzes the insertion of Fe(II) into protoporphyrin IX. In this dissertation ferrochelatase from Bacillus subtilis was studied. A new purification method via inclusion bodies was developed that enabled simple purification of recombinant enzyme without tags or modifications that might affect t

Popular Abstract in Swedish Kärleksdofter och varningsljud i bekämpning av nattfjärilar Jag har studerat hur populationer av skadegörande nattfjärilar kan bekämpas med miljövänliga metoder där djurens egna sinnessystem manipuleras. Liksom många andra insekter kommunicerar nattfjärilar med artspecifika doftsignaler (feromoner) vid parning. Honan avger doften i enstaka nanogram (miljarddels gram!) The impact of olfactory and auditory cues on the mating behaviour in two species of moths, Agrotis segetum (Noctuidae) and Plodia interpunctella (Pyralidae), was investigated to evaluate their potential use in integrated pest management. The flight behaviour of male A. segetum under natural and pheromone-based mating disruption conditions was monitored by harmonic radar. Individual males were equi

Food security is one of the world’s greatest challenges. The current food system shows an entanglement across the globe which means that local farmers reliant on subsistence agriculture no longer operate in isolation of larger-scale processes within the global economy or the changing biophysical system of the planet. The persistently high number of undernourished people, volatile food prices, incr

Background Juvenile idiopathic arthritis (JIA) is an umbrella term of inflammatory joint diseases in children. Oligoarthritis is the most common form in the Western world, representing roughly 60% of all patients. Monocytes and macrophages play an important role in adult arthritides, but their role in oligoarticular JIA is less studied. Polarization highly influences monocytes’ and macrophages’ ef

Preeclampsia (PE), is a pregnancy related condition afflicting 3-8% of all pregnancies and a main cause of maternal and infant morbidity and mortality. It is thought to originate from a malfunctioning placental that eventually leads to damage to the maternal endothelium, which in turn gives rise to hypertension and organ dysfunction. Oxidative stress holds a central role in the development, progre

Germline mutations of BRCA1 and BRCA2 predispose individuals to a high risk of breast and ovarian cancer, and elevated risk of other cancers, including those of the pancreas and prostate. BRCA2 mutation carriers may have increased risk of uveal melanoma (UM) and cutaneous melanoma (CM), but associations with these cancers in BRCA1 mutation carriers have been mixed. Here, we further assessed whethe

Short-chain fatty acids (SCFAs), gut metabolites formed from indigestible dietary components by the colonic microbiota, are associated with numerous health effects, and may be responsible for the beneficial effects, at least in part, associated with dietary fibre. High-fat diets are known to cause low-grade inflammation in the body, but SCFAs are suggested to counteract unfavourable effects induce

The association between somatic cell count (SCC) and daily milk yield in different stages of lactation was investigated in cows free of clinical mastitis (CM). Data were recorded between 1989 and 2004 in a research herd, and consisted of weekly test-day (TD) records from 1,155 lactations of Swedish Holstein and Swedish Red cows. The main data set (data set A) containing 36,117 records excluded TD

Background: The Swedish Program for health surveillance of preschool children includes screening of language and communication abilities. One important language screening is carried out at age 4 years as part of a general screening conducted by health nurses at child health centres. The instruments presently in use for this screening mainly focus on expressive phonology. This may result in both ov

Perfluoroalkyl substances (PFAS) can act as surfactants and have been suggested to be capable of affecting gut mucosa integrity, a possible factor in the pathogenesis of inflammatory bowel disease (IBD). So far, only PFOA has been shown to have a positive association with ulcerative colitis. The present study aimed to investigate the association of PFAS and clinically diagnosed IBD in the Ronneby

BACKGROUND: Arsenic exposure affects [Formula: see text] people worldwide, including [Formula: see text] in Bangladesh. Arsenic exposure increases the risk of cancer and other chronic diseases, and one potential mechanism of arsenic toxicity is epigenetic dysregulation. OBJECTIVE: We assessed associations between arsenic exposure and genome-wide DNA methylation measured at baseline among 396 Bangl