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ASPECTS OF FLUID THERAPY: An experimental study of the effects of systemic inflammation, microvascular permeability, blood pressure and plasma volume

Adequate circulating blood volume is a prerequisite for circulatory stability. Fluid therapy aims at correcting hypovolaemia, and is an important part of the haemodynamic management of perioperative and critically ill patients. The efficacy of plasma volume substitution largely depends on the pharmacological properties of the colloid solutions used. However, according to the 2-pore theory for tran

Body size and risk of colon and rectal cancer in the European prospective investigation into cancer and nutrition (EPIC)

Background: Body weight and body mass index (BMI) are positively related to risk of colon cancer in men, whereas weak or no associations exist in women. This discrepancy may be related to differences in fat distribution between sexes or to the use of hormone replacement therapy (HRT) in women. Methods: We used multivariable adjusted Cox proportional hazards models to examine the association betwee

Modern, svensk och jämställd. Om barn, familj och omvärld i grundskolans läseböcker 1962-2007

Abstract The aim of the thesis has been to explore representations of gender, ethnicity and generation in school readers used in the Swedish compulsory school since 1962, to find which ’discourses’, linked to equal opportunities, integration/diversity and childhood, underlie these constructions, and in which ways they may have contributed to the (re)production of different gendered, ethnified and

Outcome of Ischaemic Foot Ulcers in Patients with Diabetes, with or without Revascularization

Popular Abstract in Swedish Syftet med de fyra delarbeten som presenteras i denna avhandling var att studera dels utfall av fotsår samt identifiera faktorer relaterade till utfall och dels risken för att utveckla nya sår efter läkning av tidigare sår hos patienter med diabetes, fotsår och uttalad perifer kärlsjukdom. Patienter med diabetes och fotsår med ett systoliskt tåtryck <45 mmHg eller ett aThe aim of the studies presented in this thesis was to study patients with diabetes and severe peripheral arterial disease (PAD) in regard to outcomes of foot ulcers, factors related to outcomes, and occurrences of new ulcerations and amputations following healing of the initial ulcer. Patients with diabetes and a foot ulcer, consecutively presenting at a multidisciplinary foot centre, with a sys

Interpretation of response categories in patient-reported rating scales: a controlled study among people with Parkinson's disease

Background: Unambiguous interpretation of ordered rating scale response categories requires distinct meanings of category labels. Also, summation of item responses into total scores assumes equal intervals between categories. While studies have identified problems with rating scale response category functioning there is a paucity of empirical studies regarding how respondents interpret response ca

Risk of subsequent ischemic and hemorrhagic stroke in patients hospitalized for immune-mediated diseases: a nationwide follow-up study from Sweden

Background: Certain immune-mediated diseases (IMDs) have been associated with increased risk for cardiovascular disorders. The aim of the present study was to examine whether there is an association between 32 different IMDs and first hospitalization for ischemic or hemorrhagic stroke. Methods: All individuals in Sweden hospitalized with a main diagnosis of IMD (without previous or coexisting stro

Visual and non-visual effects of different spectral power distributions from light sources - light emitting diodes (LED) vs. 3-phosphorus fluorescent tubes

Light influences man both physiological and experiential and different kinds of light sources may have different impact. In a laboratory study the influence of two kinds of light sources, fluorescent tubes and LED on the experience of the surrounding lighting as well as if there were differences in the biological reactions. 42 healthy subjects took part in the study. Two levels of ambient light we

Potential for B-physics measurements with a fixed-target proton-collision experiment

Popular Abstract in Swedish Partikelfysik och det vetenskapliga arvet Har du gått i en ljus vänlig skog om sommaren när vinden susar bland löven och små djur kilar omkring under gräset och solen skiner på din hud och kittlar din amygdala i det innersta av din hjärna? Har du någonsin reflekterat över naturens oändliga rikedom? Hur kan en värld vara uppbyggd som uppvisar en sådan komplexitet? Vill HERA-B is a high-energy physics experiment at HERA. It is a fixed-target experiment with a forward spectrometer to benefit from the strong boost of beauty hadrons. The main goal of HERA-B is to detect and measure the degree of CP violation in exclusive B-decays, with emphasis on the {em golden} decay, $golden$. A computer simulated study on this decay is presented and the accuracy of the measureme

Polyphasal foreland-vergent deformation in a deep section of the 1 Ga Sveconorwegian orogen

Metamorphic belts in Precambrian shields expose deep interiors of orogens and are often challenging to interpret in tectonic terms. The Eastern Segment of the 1.1-0.9 Ga Sveconorwegian orogen is a metamorphic belt, which was metamorphosed at high-pressure granulite and upper amphibolite facies at 35-40 km depth and shows highly complex fold patterns. We use detailed structural analysis in combinat

Improvement of Physical Activity by a Kiosk-based Electronic Screening and Brief Intervention in Routine Primary Health Care: Patient-Initiated Versus Staff-Referred.

BACKGROUND: Interactive behavior change technology (eg, computer programs, Internet websites, and mobile phones) may facilitate the implementation of lifestyle behavior interventions in routine primary health care. Effective, fully automated solutions not involving primary health care staff may offer low-cost support for behavior change. OBJECTIVES: We explored the effectiveness of an electronic

Impaired quality of life and sexual function in overweight and obese men: the European Male Ageing Study

Background: Few published data link overweight and obesity with measures of quality of life (QoL) including sexual health in men. Objective: To assess the association of overweight/obesity with impairment of physical and psychological QoL and sexual functions in men. Design and setting: Cross-sectional, multicentre survey of 3369 community-dwelling men aged 40-79 (mean +/- S.D., 60 +/- 11) years r

Modeling GPP in the Nordic forest landscape with MODIS time series data - comparison with the MODIS GPP product

Satellite sensor-derived data are suitable for regional estimations of several important biophysical variables. Data with a finer spatial resolution should improve regional estimations of GPP (gross primary productivity), since they better capture the variation in a heterogeneous landscape. The main objective of this study was to investigate if MODIS 500 m reflectance data can be used to drive emp

From Pioneers to Target Group : Social Change, Ethnicity and Memory in a Lithuanian Nuclear Power Plant Community

Popular Abstract in Swedish Denna avhandling i socialantropologi ägnas åt analysen av sociala och kulturella processer i Visaginassamhället efter sovjettiden. Visaginas (tidigare Sniechkus) byggdes under sovjettiden, åren 1975-1989, som hemvist för personal vid Ignalinas kärnkraftverk och deras familjer. De flesta invånarna i staden är ryssar som kom till Litauen mellan 1975 och 1989 för att byggaThis thesis focused on an examination of human agency and strategies for responding to rapid social and economic change. Fieldwork was carried out in the community of Visaginas town that was built during the Soviet period in Lithuania. The town is situated next to the Ignalina nuclear power plant. The majority of the town's inhabitants are Russians who immigrated to Lithuania from other areas of t

Occurrence and degradation of peptidoglycan in aquatic environments

Mechanisms controlling microbial degradation of dissolved organic matter (DOM) in aquatic environments are poorly understood, although microbes are crucial to global nutrient cycling. Bacterial cell wall components may be one of the keys in understanding the presence of slowly degrading DOM in nature. We found that dominant components of bacterial cell walls (D-amino acids (D-AA), glucosamine (Glu

Neurogenesis and transplantation in stroke-damaged brain

Popular Abstract in Swedish Stroke hos unga vuxna råttor och möss utlöser neurogenes i den skadade regionen striatum samt i den intakta hippocampus, men eftersom stroke framförallt drabbar äldre individer, är det av största vikt att utröna åldrandets effekt på hjärnans mekanismer för återhämtning. Gamla och unga vuxna råttor inducerades med stroke genom transient ocklusion av mellersta hjärnartäreStroke in young adult rodents triggers neurogenesis in the damaged striatum and intact hippocampus. as stroke happens frequently in aged individuals it is of great importance to know whether aging affects brain recovery mechanisms. Aged and young adult rats were subjected to stroke by transient occlusion of the middle cerebral artery and proliferating cells were labeled by intraperitoneal administ

Basic Tendencies of Adjectival Accentological Development in Contemporary Russian

The present doctoral thesis is a study of the problem of "variation" in relation to word stress in Russian adjectives, in both their short and long forms. The stress variation in adjectival forms is investigated from various viewpoints, the main of which is the revelation of the basic processes of stress reorganisation in these groups of words and the establishment of main tendencies of adjectival

Basic Tendencies of Adjectival Accentological Development in Contemporary Russian

The present doctoral thesis is a study of the problem of "variation" in relation to word-stress in Russian adjectives, in both their short and long forms. The stress variation in adjectival forms is investigated from various viewpoints, the main of which is the revelation of the basic processes of stress reorganisation in these groups of words and the establishment of main tendencies of adjectival

The association between diabetic nephropathy and autonomic nerve function in type 1 diabetic patients

Diabetic cardiovascular autonomic neuropathy increases the risk of deterioration in renal function and is associated with increased mortality in patients with renal failure. Type 1 diabetic patients with long diabetes duration, matched for age (38 +/- 9 years) and diabetes duration (28 +/- 8 years) were studied regarding the association between cardiovascular autonomic nerve function and different

New predictive and diagnostic biomarkers for preeclampsia

Abstract Preeclampsia is a serious pregnancy complication that affects 3-8% of all pregnancies leading to maternal- and fetal morbidity and mortality. The etiology is still not known in detail. Previous findings have shown an up regulation of the genes coding for fetal hemoglobin (HbF) in preeclamptic placentas. The cell-free HbF protein was shown to be accumulating in the vascular lumen, to induc