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Tensins are large intracellular proteins believed to link the extracellular matrix to the cytoskeleton via integrins. Tensins are multidomain proteins consisting of homologous C1, PTPase, C2, SH2 and PTB domains. Full-length Tensin proteins can undergo cleavage inside cells, thus yielding domains in isolation that may have discrete subcellular localisations and downstream effects. We expressed dif
The single Trp of human cystatin C, Trp-106, is located in the second hairpin loop of the proteinase binding surface. Substitution of this residue by Gly markedly altered the spectroscopic changes accompanying papain binding and reduced the affinity for papain, actinidin, and cathepsins B and H by 300-900-fold. The decrease in affinity indicated that the side chain of Trp-106 contributes a similar
Training and communication are essential elements in the implementation of environmental management systems (EMS). This study is based on two main questions: (i) What methods for training and communication will support the implementation of EMS at a university? and, (ii) How did faculty and staff perceive the training and communication activities? The study includes a literature review, a case stu
What conformations do protein molecules populate in solution? Crystallography provides a high-resolution description of protein structure in the crystal environment, while NMR describes structure in solution but using less data. NMR structures display more variability, but is this because crystal contacts are absent or because of fewer data constraints? Here we report unexpected insight into this
The aim of this study was to investigate how physico-chemical properties of two dietary fibres, guar gum and pectin, affected weight gain, adiposity, lipid metabolism, short-chain fatty acid (SCFA) profiles and the gut microbiota in male Wistar rats fed either low- or high-fat diets for three weeks. Both pectin and guar gum reduced weight gain, adiposity, liver fat and blood glucose levels in rats
BACKGROUND: The character higher order scales (self-directedness, cooperativeness, and self-transcendence) in the temperament and character inventory are important general measures of health and well-being [Mens Sana Monograph 11:16-24 (2013)]. Recent research has found suggestive evidence of common environmental influence on the development of these character traits during adolescence. The pres
A central hypothesis of ecological immunology is that immune defences are traded off against competing physiological and behavioural processes. During energetically demanding periods, birds are predicted to switch from expensive inflammatory responses to less costly immune responses. Acute phase responses (APRs) are a particularly costly form of immune defence, and, hence, seasonal modulations in
The overall aim of this thesis was to increase our knowledge of engagement in occupations in persons with Multiple Sclerosis (MS) in order to develop client-centred occupational therapy and rehabilitation. In study I, observations of the performance of self-care and household occupations were pursued in 44 participants, and study II identified self-perceived problems in performance of occupations
This bachelor’s thesis in statistics explores frequentist and bayesian methods for parameter estimation and compares their usefulness when applied to opinion polls of party sympathies in the Swedish political system. Through simulation in R, random samples are generated from a population modelled after the Swedish electorate at various points during the 2010s and 2020s. The party for which each in
Background: The IKEA Range & Supply organisation consists of business areas (BAs) and categories. BAs work with product development toward end-customers while the material-based categories work toward suppliers with purchasing and sourcing related tasks. There exists an internal cross-organisational interface between these units and IKEA recently created Sourcing Assignment as a tool to encour
Abstract Authors: Alexandra Jönsson & Emmeli Trobäck Title: We never force a child [translated title] Supervisor: Claes Levin Assessor: Kristina Göransson Our purpose with this paper was to try to get a better understanding of how a social worker acts and thinks in their assessments. Especially in the interaction between a foster child and the biological parents along with what role the child
Can children really be psychopaths? – A qualitative study about social workers’ view on children with psychopathic traits. The purpose of this study was to investigate how children with psychopathic traits are presented by investigators and therapists in order to gain a greater understanding of the social and cultural opportunities and limitations to approaching the phenomenon of psychopathy in c
The purpose of this bachelor thesis was to study the experiences that children had growing up in poor living conditions due to their parent's substance abuse. The children included in this study are in adult age describing their childhood in relation to their parents substance abuse and the effect it had on them. The consequences both short-term and long-term, as well as the mental health of t
Purpose: The main purpose of this study is to examine how the short-term performance of European acquirers, following M&A announcements, has been affected by the COVID-19 pandemic. In addition, this study also aims to examine how diversifying M&As have been affected, and whether acquirers’ firm value demonstrated a positive relationship with CARs during the pandemic. Methodology: This stu
The aim of this essay is to investigate how common so called Baptismal Trees are in the Church of Sweden, and analyse their origin and function, as well as inquire what role the Baptismal Tree has within the Swedish Church. Usually, a Baptismal Tree is a tree, but it can also be a painting, a fishnet, or a display case visible to the congregation in a church room. Symbolic christening gifts, given
Thesis purpose: The aim of this study was to examine whether German Millennials are in favor of rejuvenation practices of heritage luxury fashion brands or if such actions instead lead to negative associations, as they tend to ignore the heritage aspect. Methodology: Following a relativist ontology, this research is guided by a social constructionist position, which allows a deep understanding of
Acidification was one of the biggest environmental issues during the 20th centaury, especially in Sweden since acidic emissions from other regions ended up in the ground and water here. In this study, data from several lakes in Ulricehamn Municipality was analysed with consideration of acidification. Liming has been carried out in three lakes, Surströmmasjön, Vallsjön and Trehörningen, since the 1
Systemic Lupus Erythematosus, SLE, is a disease with a large variation of symptoms. Some patients have neuropsychiatric symptoms, such as cognitive dysfunction and epilepsy. The classification of patients into NPSLE, with neuropsychiatric symptoms, and non-NPSLE, without these symptoms, is uncertain. Studying the white matter microstructure of SLE patients and comparing this with healthy controls
Problem discussion: To be more competitive, Trading Area Wood is working on developing their suppliers in efficiency projects. However, they find it hard to motivate their suppliers to take part in the projects. Therefore, they need a way to show the suppliers the positive effects of participating in the efficiency projects. Moreover, Trading Area Wood has troubles to predict the economical outcom
Denna uppsats beskriver lagstiftningen angående marknadsdefinition, framförallt av koncentrationer unionsdimension. Slutsatserna appliceras sen till en analys av plattvärmeväxlarindustrin (PHE) för att producera ett exempel på hur en sådan argumentation kan föras. Följaktligen presenteras bakgrundsinformation om plattvärmeväxlarindustrin i kapitel 2. Där presenteras även två separata teknologier (An essay describing the legal regime governing market definition, particularly concerning concentration cases having a Union dimension. The author high-lights difficulties under the current legal regime, consisting mainly of the EU Commission’s Relevant Market Notice and case law. It is concluded that though this gives some guidance, case-law as well as doctrine indicates that parties will be able
