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Background Assessment of left ventricular function and dimensions is central for cardiac diagnostic imaging with cardiac positron emission tomography (PET) and myocardial perfusion single-photon emission computed tomography (MPS). The aim of this study was to compare [13N]NH3 PET and MPS, head-to-head, for assessment of left ventricular ejection fraction (LVEF) and volumes using cardiac magnetic r

Background: Early metastatic spread represents a challenge in fighting small cell lung cancer (SCLC). The molecular mechanisms underlying metastatic dissemination remain unclear in this devastating disease. Methods: Invasive traits were investigated in 13 SCLC cell lines using 3D-spheroid formation, sprouting assays, co-cultures and a zebrafish xenograft model. Proteomic analysis was performed to

Mitochondria play a crucial role in metabolism and energy production by generating adenosine triphosphate (ATP) through oxidative phosphorylation. They also help maintain intracellular calcium levels, facilitate communication between the nucleus and cytoplasm, detoxify reactive oxygen species (ROS), and regulate apoptosis. Reversible acetylation of mitochondrial proteins is a key post-translationa

Introduction The Problematic Experience of Therapy Scale (PETS) identifies barriers to home-based exercise programs but has not been validated in hand therapy populations. This study aimed to translate the extended PETS into Swedish and evaluate its content and construct validity in patients undergoing early sensory relearning following peripheral nerve injury.Methods The PETS was translated into

Possession of flowers that trap fly pollinators is a conservative trait within the genus Ceropegia, in which pollination systems can be generalized or highly specialized. However, little is known about the role of plant–pollinator interactions in the maintenance of species boundaries. This study examined the degree of plant–pollinator specialization and identified the parameters responsible for sp

Cetaceans are negatively affected by anthropogenic activities, including acoustic and physical disturbance from boat traffic. Behavioural responses to such disturbances are context-dependent, and site-specific insights are needed for effective local management plans. In this study, the impact of speed and proximity of recreational boats on the swimming speed and surfacing interval of one of the mo

Introduction To assess how national income level influences global variation in the diagnosis and management of heart failure with preserved ejection fraction (HFpEF). Methods A web-based survey on HFpEF diagnosis and treatment was distributed worldwide from May to July 2023 through email, scientific societies, and social networks. Respondents provided demographic information and details on diagno

Importance The clinical utility of the comprehensive laboratory and medical investigations currently recommended for children with pediatric acute-onset neuropsychiatric syndrome (PANS) remains unclear. Notably, comparisons with relevant psychiatric control patients without suspected immunologic pathogenesis are lacking. Objective To evaluate whether currently recommended laboratory investigations

This study focused on expression, purification and functional characterization of three key proteins (Urc1p, Urc2p and Urc8p) in the newly discovered uracil catabolism (URC) pathway. A novel expression system was established by using Saccharomyces kluyveri as a host organism for expression of 6-His tagged Urc1p and Urc2p. Moreover, URC8 gene was cloned in pET151/D-TOPO vector and expressed in Esch

Background: Recently developed buprenorphine depot injections have the potential to reduce risk for diversion and misuse, and to increase adherence with fewer visits for supervised intake. However, it is unclear how patients perceive this new form of medication. The purpose of this study was to explore patients experiences of depot injections and their reasons for continuing, discontinuing, or dec

Medical Physicist, Principal investigator, PhD, Postdoc Affiliation: Haematology, Oncology and Radiation Physics, Skåne University Hospital, Lund. Medical Radiation Physics, Department of Translational Medicine, Lund University.  Employment: Radiotherapy, Lund. Education: Lund University, University of North Carolina, Kyoto University.  PhD thesis: Measurement of Tumor Extent and Effects of Breast

https://www.luci.lu.se/en/daniel-fornvik - 2026-05-09

Få grepp om hjärnan Området i hjärnan som styr händerna och uppfattar känsel i dem är väldigt stort jämfört med andra områden. Skador i den delen av hjärnan, som kan bero på sjukdomar eller olyckor, orsakar ofta problem med att utföra vardagliga handrörelser. Problemen kan minska mycket med hjälp av specifik rörelseträning, men vi vet än idag inte hur vi på bästa sätt ska utforma rörelseträningenTraumatic brain injury and diseases causing cortical damage is a global problem. Despite their vast extent, their pathophysiology is poorly understood. It is however known that the loss of motor functions can be regained thanks to adaptive properties of the neuronal system. Early task specific motor training is proven to be critical for rehabilitation. We set out to better understand how the CNS c

I 40 år hade Sverige en lagstiftning som möjliggjorde sterilisering utan samtycke av de som saknade rättskapacitet. 62.888 operationer utfördes under dessa år, närmare bestämt mellan 1935–1975. Frågan jag ställde mig var huruvida samtliga ingrepp genomförts som ett resultat av myndighetstvång eller ifall det även förekom frivillig sterilisering. Mellan 1935–1941 var frivillig sterilisering inte mö

I Sveriges olycksstatistik är män tydligt överrepresenterade och detta syns främst i olyckor inom trafiken och förgiftningsolyckor. Bland trafikolyckor är ca 75 % av de som omkommer män och främst unga män i åldrarna 18 - 25. Detta samband mellan genus och olyckor kan vara av intresse för Sveriges trafiksäkerhetsarbete för att i längden uppnå Nollvisionen. Frågan är vad som skulle kunna göras och During decades men, and especially young adults, have been overrepresented in statistics for traffic accidents. It is known that this trend is linked to men’s riskier behaviour when driving. Sweden has a zero vision (Nollvisionen), which states that no one should die or be seriously injured in traffic and is applied for all road safety work. Therefore, it is of interest to work to prevent risk beh

Bakgrund: Årligen diagnostiseras över 6900 personer i bröstcancer och utgör den vanligast förekommande dödsorsaken hos kvinnor. Möjligheten att upptäcka sjukdomen i ett tidigt skede har ökat i Sverige då kvinnor i åldrarna 40-74 erbjuds hälsokontroller med mammografiscreening. Syftet med denna litteraturstudie var att beskriva kvinnors upplevelser av mammografiscreening. Metod: En litteraturstudieIntroduction: Breast cancer is the most common death cause among women, more than 6900 women are diagnosed every year. The opportunity to discover the disease in an early stage has increased due to all women in Sweden are offered health checks with mammography screening. The aim of this study was to examine women's experiences of mammography screening. Method: The study was conducted as a lite

The purpose of this thesis is to answer the question: is it possible to outperform the OMXS30 index by using an investment strategy based on the Black Swan theory? With increased globalization and technological development, the world has become more and more complex and economic models and theories cannot capture all the sources to risk. There are also several limitations to the human mind which m

In forest biomass estimations, three dimensional (3D) canopy structure data derived from images captured by unmanned aerial vehicles (UAVs), also known as drones, has shown potential due to the flexibility and cost efficiency of the method. However, little research has been done for its applicability in bioenergy forest. In this study, a method was developed with the purpose of remotely estimating

Källsortering i historiska byggnader - är det möjligt? God avfallshantering och ökad materialåtervinning är viktiga pusselbitar i mänsklighetens strävan efter en hållbar utveckling. Att införa källsorteringssystem i vissa byggnader är dock lättare sagt än gjort. AF-borgen i Lund, Akademiska föreningens hus, är ett exempel på en byggnad där det uppkommer betydande mängder avfall, men där möjlighGood waste management is essential to reach a sustainable development, although it is not always easy to achieve. Historical buildings have several requirements concerning fire security, working environment and aesthetics which can make it hard for them to introduce sorting systems. The purpose of this study is to investigate the obstacles historical buildings can encounter concerning indoor waste

This thesis aims to analyse the effects on the Swedish economic growth as a result of growing carbon dioxide emissions during the period of 2017-2060. As being one of the Nordic countries, predicted to be one of the few least affected countries by global warming, Sweden will still most likely face the challenges of rising sea levels and more extreme weather events that will cause damages on infras