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AIMS: To describe the occurrence of psychiatric diagnoses in a specialist care setting in older people with intellectual disability (ID) in relation to those found in the same age group in the general population.METHOD: A cohort of people with ID (n = 7936), aged 55 years or more in 2012, was identified, as was an age and sex-matched cohort from the general population (n = 7936). Information regar

BACKGROUND: Small molecule inhibitors of phosphatidylinositol-3 kinase (PI3K) have been developed as molecular therapy for cancer, but their efficacy in the clinic is modest, hampered by resistance mechanisms.METHODS: We studied the effect of PI3K therapy in patient-derived tumor organotypic cultures (from five patient samples), three glioblastoma (GBM) tumor cell lines, and an intracranial model

In this work we demonstrate a two-fold selectivity control of InAs shells grown on crystal phase and morphology engineered GaAs nanowire (NW) core templates. This selectivity occurs driven by differences in surface energies of the NW core facets. The occurrence of the different facets itself is controlled by either forming different crystal phases or additional tuning of the core NW morphology. Fi

The complement system constitutes a crucial part of the innate immunity, mediating opsonization, lysis, inflammation, and elimination of potential pathogens. In general, there is an increased activity of the complement system during pregnancy, which is essential for maintaining the host’s defense and fetal survival. Unbalanced or excessive activation of the complement system in the placenta is ass

Aims/hypothesis: The aetiology of type 1 diabetes remains elusive. Family history of type 1 diabetes increases the disease risk but the role of other autoimmune diseases or type 2 diabetes in the family are unclear. Here, we aimed to analyse the effect of family history of diabetes and autoimmune diseases on development of islet autoimmunity and progression to type 1 diabetes. Methods: The Environ

Background Assessment of left ventricular function and dimensions is central for cardiac diagnostic imaging with cardiac positron emission tomography (PET) and myocardial perfusion single-photon emission computed tomography (MPS). The aim of this study was to compare [13N]NH3 PET and MPS, head-to-head, for assessment of left ventricular ejection fraction (LVEF) and volumes using cardiac magnetic r

Background: Early metastatic spread represents a challenge in fighting small cell lung cancer (SCLC). The molecular mechanisms underlying metastatic dissemination remain unclear in this devastating disease. Methods: Invasive traits were investigated in 13 SCLC cell lines using 3D-spheroid formation, sprouting assays, co-cultures and a zebrafish xenograft model. Proteomic analysis was performed to

Mitochondria play a crucial role in metabolism and energy production by generating adenosine triphosphate (ATP) through oxidative phosphorylation. They also help maintain intracellular calcium levels, facilitate communication between the nucleus and cytoplasm, detoxify reactive oxygen species (ROS), and regulate apoptosis. Reversible acetylation of mitochondrial proteins is a key post-translationa

Introduction The Problematic Experience of Therapy Scale (PETS) identifies barriers to home-based exercise programs but has not been validated in hand therapy populations. This study aimed to translate the extended PETS into Swedish and evaluate its content and construct validity in patients undergoing early sensory relearning following peripheral nerve injury.Methods The PETS was translated into

Possession of flowers that trap fly pollinators is a conservative trait within the genus Ceropegia, in which pollination systems can be generalized or highly specialized. However, little is known about the role of plant–pollinator interactions in the maintenance of species boundaries. This study examined the degree of plant–pollinator specialization and identified the parameters responsible for sp

Cetaceans are negatively affected by anthropogenic activities, including acoustic and physical disturbance from boat traffic. Behavioural responses to such disturbances are context-dependent, and site-specific insights are needed for effective local management plans. In this study, the impact of speed and proximity of recreational boats on the swimming speed and surfacing interval of one of the mo

Introduction To assess how national income level influences global variation in the diagnosis and management of heart failure with preserved ejection fraction (HFpEF). Methods A web-based survey on HFpEF diagnosis and treatment was distributed worldwide from May to July 2023 through email, scientific societies, and social networks. Respondents provided demographic information and details on diagno

Importance The clinical utility of the comprehensive laboratory and medical investigations currently recommended for children with pediatric acute-onset neuropsychiatric syndrome (PANS) remains unclear. Notably, comparisons with relevant psychiatric control patients without suspected immunologic pathogenesis are lacking. Objective To evaluate whether currently recommended laboratory investigations

This study focused on expression, purification and functional characterization of three key proteins (Urc1p, Urc2p and Urc8p) in the newly discovered uracil catabolism (URC) pathway. A novel expression system was established by using Saccharomyces kluyveri as a host organism for expression of 6-His tagged Urc1p and Urc2p. Moreover, URC8 gene was cloned in pET151/D-TOPO vector and expressed in Esch

Background: Recently developed buprenorphine depot injections have the potential to reduce risk for diversion and misuse, and to increase adherence with fewer visits for supervised intake. However, it is unclear how patients perceive this new form of medication. The purpose of this study was to explore patients experiences of depot injections and their reasons for continuing, discontinuing, or dec

Få grepp om hjärnan Området i hjärnan som styr händerna och uppfattar känsel i dem är väldigt stort jämfört med andra områden. Skador i den delen av hjärnan, som kan bero på sjukdomar eller olyckor, orsakar ofta problem med att utföra vardagliga handrörelser. Problemen kan minska mycket med hjälp av specifik rörelseträning, men vi vet än idag inte hur vi på bästa sätt ska utforma rörelseträningenTraumatic brain injury and diseases causing cortical damage is a global problem. Despite their vast extent, their pathophysiology is poorly understood. It is however known that the loss of motor functions can be regained thanks to adaptive properties of the neuronal system. Early task specific motor training is proven to be critical for rehabilitation. We set out to better understand how the CNS c

I 40 år hade Sverige en lagstiftning som möjliggjorde sterilisering utan samtycke av de som saknade rättskapacitet. 62.888 operationer utfördes under dessa år, närmare bestämt mellan 1935–1975. Frågan jag ställde mig var huruvida samtliga ingrepp genomförts som ett resultat av myndighetstvång eller ifall det även förekom frivillig sterilisering. Mellan 1935–1941 var frivillig sterilisering inte mö

I Sveriges olycksstatistik är män tydligt överrepresenterade och detta syns främst i olyckor inom trafiken och förgiftningsolyckor. Bland trafikolyckor är ca 75 % av de som omkommer män och främst unga män i åldrarna 18 - 25. Detta samband mellan genus och olyckor kan vara av intresse för Sveriges trafiksäkerhetsarbete för att i längden uppnå Nollvisionen. Frågan är vad som skulle kunna göras och During decades men, and especially young adults, have been overrepresented in statistics for traffic accidents. It is known that this trend is linked to men’s riskier behaviour when driving. Sweden has a zero vision (Nollvisionen), which states that no one should die or be seriously injured in traffic and is applied for all road safety work. Therefore, it is of interest to work to prevent risk beh