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Background Progression of joint destruction in rheumatoid arthritis (RA) is partly heritable; knowledge of genetic factors may increase our understanding of the mechanisms underlying joint destruction. The activity of the Wnt/beta-catenin pathway influences osteoblast differentiation. Dickkopf-1 (Dkk-1) and sclerostin (Sost) are negative regulators and lipoprotein receptor-related protein-5 (LRP-5
Background: It is well established that drinking alcohol raises the risk of liver cancer (hepatocellular carcinoma). However, it has not been sufficiently established as to whether or not drinking cessation subsequently reduces the risk of liver cancer and if it does reduce the risk how long it takes for this heightened risk to fall to that of never drinkers. This question is important for effecti
Pleistocene glacial cycles play a major role in diversification and speciation, although the relative importance of isolation and expansion in driving diversification remains debated. We analysed mitochondrial DNA sequence data from 15 great reed warbler (Acrocephalus arundinaceus) populations distributed over the vast Eurasian breeding range of the species, and revealed unexpected postglacial exp
This is the first impact analysis that exclusively deals with R&D funding taking place after the foundation of VINNOVA. Since the long-term effects of R&D projects are visible only years after the ending of the projects the analysis deals with impacts expected to be found in a shorter time span. The focus of the present impact analysis is to identify and analyze the presence and strength o
In terrestrial ecosystems, the largest pool of amorphous silica (ASi) is stored in soils and is an important reservoir of biologically active Si for the global biogeochemical cycling of Si. Only limited data are available that quantify the size of this reservoir and often these estimates are made from the physical separation of silt-sized phytoliths, which can underestimate the ASi pool. Soil samp
In this work, we provide a detailed microscopic picture of the behavior of benzoic acid at the aqueous solution/vapor interface in its neutral as well as in its dissociated form (benzoate). This is achieved through a combination of highly surface-sensitive X-ray photoelectron spectroscopy experiments and fully atomistic molecular simulations. We show that significant changes occur in the interface
Various microchannel heat sinks for dissipating heat loads have received great attention. Wavy channels are recognized to be suitable to enhance the heat transfer, and are successfully applied in heat-exchange devices. In this article, three kinds of water-cooled microchannel heat sinks, such as a rectangular straight microchannel heat sink, a single-layer wavy microchannel heat sink and a double-
We report the first measurement of the near oxygen K-edge auger spectrum of the glycine molecule. Our work employed an x-ray free electron laser as the photon source operated with input photon energies tunable between 527 and 547 eV. Complete electron spectra were recorded at each photon energy in the tuning range, revealing resonant and non-resonant auger structures. Finally ab initio theoretical
The birth, growth and maturity of industries, sectors and technologies have spurred the curiosity of researchers as well as managers and policy makers for a long time. Intriguingly, the emergence of a new industry is a complex process including many different actors and with a high level of uncertainty related to technology, institutions and markets facing the actors involved. Empirically this b
This article seeks to explore how Christian self-understanding has changed as Jewish-Christian relations have enhanced and improved during the last half-century. To what extent are traditional Christological and soteriological models and motifs discussed, defined, redefined, refined or even refuted? Three issues are discussed: the need to (a) go beyond bipolarity (Judaism vis-à-vis Christianity et
In this paper, cultural transmission between Slavs and Scandinavians from ca 900 to 1250 is discussed. Cultural identity and identity negotiation through style are topics often studied in higher social strata of societies. Emblemic style is maintained and displayed in jewellery or other eye-catching parts of the material culture to distinguish oneself in relation to others. However, the constructi
A society’s ability to anticipate disaster is a fundamental part of its resilience. The purpose of this paper is to investigate potential gaps between theory, policy and practice concerning functions for risk assessment in the governmental systems of southern African development countries, particularly Botswana and Tanzania. It applies comparative case studies with data collected in focus groups a
Popular Abstract in Swedish Utvecklingen av säkrare och mer miljövänliga processer är en av de största utmaningarna som den kemiska industrin står inför. I det här sammanhanget är katalys i tvåfassystem, bestående av vatten och organiska lösningsmedel, av största intresse eftersom den möjliggör en enkel återvinning av katalysatorn samtidigt som den minskar skadliga utsläpp och kostnader för återviThe steric and electronic properties of eight water-soluble phosphines (1-8) were investigated by different methods. Phosphines 1-6 were tested as ligands in palladium catalysed hydroxycarbonylation of styrene. In line with the proposal that a ligand with low basicity should facilitate nucleophilic attack of water on the acyl complex, the electron rich {4 - [Bis(2 - diethylaminoethyl)] - aminobenz
Non-state actors have been increasingly engaged in regulation, operating and setting rules outside of, and parallel to, existing legal institutions. These “alternative to legal rules” have been increasingly influential in domestic law and policy, with growing evidence of them penetrating legal, professional, as well as social orders. This thesis adopts the case of sustainability assurance to analy
This chapter addresses the question of the growth of accuracy and complexity in L2 French from the perspective of developmental sequences of morphosyntax, developmental stages and linguistic profiling. We examine the systematic growth of morphosyntactic features expressed by the learner during the acquisition process (sequences). Furthermore, we investigate the relatedness of different development
An in-house written software package was used to generate templates of QRS complexes and T waves using self-similarity techniques, and leave a residual signal representing only atrial activity. The templating performance differences between individual ECG leads were tested. The mean number of templates in each of the 3 ECG leads was 8±4, 2±1, 7±5 for the QRS complexes, and 11±5, 11±8, 10±5 for the
In this thesis, I have studied continuously managed semi-natural meadows in south-central Sweden. The purpose was 1) to make a survey of meadow vegetation in the region 2) to compare two investigations of the vegetation, one from 1963-1966 and one from 1990 3) to investigate experimentally in the field how increased nitrogen supply rate as well as changed management intensity effects the nitrogen
