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Cyclic nucleotide phosphodiesterase (PDE) 3B plays an important role in the antilipolytic action of insulin and, thereby, the release of fatty acids from adipocytes. Increased concentrations of circulating fatty acids as a result of elevated or unrestrained lipolysis cause insulin resistance. The lipolytic action of tumor necrosis factor (TNF)-alpha is thought to be one of the mechanisms by which
Measurements are presented of inclusive charm and beauty cross sections in e(+)p collisions at HERA for values of photon virtuality 12 <= Q(2) = 60 GeV2 and of the Bjorken scaling variable 0.0002 <= x <= 0.005. The fractions of events containing charm and beauty quarks are determined using a method based on the impact parameter, in the transverse plane, of tracks to the primary vertex, as measured
A measurement of the W boson mass and width has been performed by the DELPHI collaboration using the data collected during the full LEP2 programme (1996-2000). The data sample has an integrated luminosity of 660 pb(-1) and was collected over a range of centre-of-mass energies from 161 to 209 GeV. Results are obtained by applying the method of direct reconstruction of the mass of the W from its dec
The reconstruction of photons in the ATLAS detector is studied with data taken during the 2004 Combined Test Beam, where a full slice of the ATLAS detector was exposed to beams of particles of known energy at the CERN SPS. The results presented show significant differences in the longitudinal development of the electromagnetic shower between converted and unconverted photons as well as in the tota
The voluminous Kalkarindji flood basalts erupted in Australia during the Cambrian and covered >2 x 10(6) km(2). New U-Pb and Ar-40/Ar-39 age data from intrusive rocks and lava flows yielded statistically indistinguishable ages at ca. 511 Ma, suggesting a relatively brief emplacement for this province. A zircon age of 510.7 +/- 0.6 Ma shows that this province is temporally indistinguishable at the
U ranijim istraživanjima ratnog nasilja, tokom rata u Bosni i Hercegovini, naglašavana je važnost priča ŽRTAVA ali fokus analize nije bio usmjeren na priče o ratnom nasilju, niti su analizirani poslijeratni intervjui kao produkt međuljudske interakcije. Ovom studijom pokušava se popuniti ta praznina analiziranjem priča osoba koje su preživjele rat u sjeverozapadnoj Bosni i Hercegovini. Prvi cilj s
Background Progression of joint destruction in rheumatoid arthritis (RA) is partly heritable; knowledge of genetic factors may increase our understanding of the mechanisms underlying joint destruction. The activity of the Wnt/beta-catenin pathway influences osteoblast differentiation. Dickkopf-1 (Dkk-1) and sclerostin (Sost) are negative regulators and lipoprotein receptor-related protein-5 (LRP-5
Background: It is well established that drinking alcohol raises the risk of liver cancer (hepatocellular carcinoma). However, it has not been sufficiently established as to whether or not drinking cessation subsequently reduces the risk of liver cancer and if it does reduce the risk how long it takes for this heightened risk to fall to that of never drinkers. This question is important for effecti
Pleistocene glacial cycles play a major role in diversification and speciation, although the relative importance of isolation and expansion in driving diversification remains debated. We analysed mitochondrial DNA sequence data from 15 great reed warbler (Acrocephalus arundinaceus) populations distributed over the vast Eurasian breeding range of the species, and revealed unexpected postglacial exp
This is the first impact analysis that exclusively deals with R&D funding taking place after the foundation of VINNOVA. Since the long-term effects of R&D projects are visible only years after the ending of the projects the analysis deals with impacts expected to be found in a shorter time span. The focus of the present impact analysis is to identify and analyze the presence and strength o
In terrestrial ecosystems, the largest pool of amorphous silica (ASi) is stored in soils and is an important reservoir of biologically active Si for the global biogeochemical cycling of Si. Only limited data are available that quantify the size of this reservoir and often these estimates are made from the physical separation of silt-sized phytoliths, which can underestimate the ASi pool. Soil samp
In this work, we provide a detailed microscopic picture of the behavior of benzoic acid at the aqueous solution/vapor interface in its neutral as well as in its dissociated form (benzoate). This is achieved through a combination of highly surface-sensitive X-ray photoelectron spectroscopy experiments and fully atomistic molecular simulations. We show that significant changes occur in the interface
Various microchannel heat sinks for dissipating heat loads have received great attention. Wavy channels are recognized to be suitable to enhance the heat transfer, and are successfully applied in heat-exchange devices. In this article, three kinds of water-cooled microchannel heat sinks, such as a rectangular straight microchannel heat sink, a single-layer wavy microchannel heat sink and a double-
We report the first measurement of the near oxygen K-edge auger spectrum of the glycine molecule. Our work employed an x-ray free electron laser as the photon source operated with input photon energies tunable between 527 and 547 eV. Complete electron spectra were recorded at each photon energy in the tuning range, revealing resonant and non-resonant auger structures. Finally ab initio theoretical
The birth, growth and maturity of industries, sectors and technologies have spurred the curiosity of researchers as well as managers and policy makers for a long time. Intriguingly, the emergence of a new industry is a complex process including many different actors and with a high level of uncertainty related to technology, institutions and markets facing the actors involved. Empirically this b
This article seeks to explore how Christian self-understanding has changed as Jewish-Christian relations have enhanced and improved during the last half-century. To what extent are traditional Christological and soteriological models and motifs discussed, defined, redefined, refined or even refuted? Three issues are discussed: the need to (a) go beyond bipolarity (Judaism vis-à-vis Christianity et
In this paper, cultural transmission between Slavs and Scandinavians from ca 900 to 1250 is discussed. Cultural identity and identity negotiation through style are topics often studied in higher social strata of societies. Emblemic style is maintained and displayed in jewellery or other eye-catching parts of the material culture to distinguish oneself in relation to others. However, the constructi
