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Accumulating data suggest that neutrophil extracellular traps (NETs) exert a key function in several diseases. Peptidylarginine deiminase 4 (PAD4) regulates NET formation via citrullination of histones. The aim of this study was to examine the role of miR-155 in controlling PAD4-dependent generation of NETs. Bone marrow neutrophils were stimulated with PMA and MIP-2. Pre-incubation of neutrophils
The report draws on socio-legal theory in relation to growing concerns over fairness, accountability and transparency of societally applied artificial intelligence (AI) and machine learning. The purpose is to contribute to a broad socio-legal orientation by describing legal and normative challenges posed by applied AI. To do so, the article first analyses a set of problematic cases, e.g. image rec
We perform hydrodynamic simulations of mass transfer in binaries that contain a white dwarf and a neutron star (WD-NS binaries), and measure the specific angular momentum of material lost from the binary in disc winds. By incorporating our results within a long-term evolution model, we measure the long-term stability of mass transfer in these binaries. We find that only binaries containing helium
The effect of a nonspherical particle shape on the dynamics in crowded solutions presents a significant challenge for a comprehensive understanding of interaction and structural relaxation in biological and soft matter. We report that small deviations from a spherical shape induce a nonmonotonic contribution to the crowding effect on the short-time cage diffusion compared with spherical systems, u
In the present study, water-oil flow patterns and slug hydrodynamics were experimentally studied in square glass microchannels with various hydraulic diameters (Dh = 600 µm, 400 µm, 200 µm). The aqueous phase is the continuous phase while the organic phase is the dispersed phase. The ranges of flow rates of the continuous phase and the dispersed phase are 0-200 ml/h and 0-12 ml/h, 0-120 ml/h and 0
The effects of inhaled 1,1,1-trichloroethane (3500, 6000, and 7800 ppm) on behavior, local cerebral blood flow, and local cerebral glucose consumption were studied in awake rats. The effect of the solvent inhalation on the EEG pattern and local cerebral blood flow was also studied in paralyzed animals under N2O analgesia. Exposure of awake animals to 6000 ppm 1,1,1-trichloroethane induced a decrea
Huge dynamic Stark shifts of atomic energy levels in xenon induced by high-intensity laser light have been measured by a new method based upon multiphoton ionization by a tunable femtosecond laser source. Stark-induced multiphoton resonances appear as identifiable structures in the photoelectron energy spectra. The change in the structures positions, when the photon energy is tuned, is directly re
Families often prefer home care to hospital care, and home-care services for ill children are increasing worldwide with limited knowledge of families’ needs during curative and palliative home care. The aim of this study was to elucidate family members’ lived experience when a sick child received home care from county-based primary healthcare services. A descriptive qualitative design was chosen a
After an initial clarification of the notion of the risk, a brief discussion of the distinction between testing and screening, and of the difficulties of defining genetic information in a precise way follows an overview of public concerns raised by genetic testing and screening. Next section reviews various types of ethical issues in this context. The challenges are not the same for all types and
This paper deals with noise suppression in multichannel measurements, using a certain signal model but without assuming stationarity of the signals involved. This enables application to signals whose spectral characteristics are time-variable. The novelty consists of an algorithm for obtaining an approximation of the Wiener filter for each channel. The filters are computed using the Weyl transform
BACKGROUND: Three-dimensional (3D) printing of highly porous orthopaedic implants aims to promote better osseointegration, thus preventing aseptic loosening. However, short-term radiostereometric analysis (RSA) after total knee arthroplasty (TKA) has shown higher initial migration of cementless 3D-printed tibial components compared with their cemented counterparts. Therefore, critical evaluation o
Background: Radiostereometric analysis (RSA) studies have shown that the continuous migration of tibial components is predictive of aseptic loosening following total knee arthroplasty (TKA). In the present study, we investigated whether accurate sizing and placement of tibial components are related to the degree of implant migration as measured with use of RSA.Methods:A total of 111 patients who u
