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Stage- and lineage-specific gene expression patterns are controlled by a complex interplay between transcription factors, the epigenetic landscape, and the three-dimensional (3D) structure of the DNA. The 3D structure allows for the formation of DNA loops that juxtaposition distal regulatory elements to the promoters, allowing for tight control of gene expression. Developing a tool to facilitate t

Purpose: This systematic literature review aims to develop a comprehensive understanding of effort as a multidimensional construct in individuals with impaired swallowing and/or spoken communication. Method: A comprehensive literature search was conducted across three data-bases: PubMed/MEDLINE, Embase, and CINAHL, covering publications from 1966 to 2024. The search included terms related to commu

Early recognition and management of sports-related concussion (SRC), including removal from the sports activity, is essential for player safety and to prevent long-term symptoms. A graduated, stepwise rehabilitation protocol is implemented to allow the athlete to return to sports. In 2022, the 6th international consensus statement on concussion in sports was presented, which has now been adapted t

This study compared and examined the electroencephalogram(EEG)-based driver inattention warning system with actual bus drivers in real-road environments. EEG and survey data were gathered from 20 professional bus drivers who drove their buses under the conditions in which the warning systems were turned on and off for 47 days. The analysis revealed that the ratio of the SMR-mid beta to theta(RSMT)

Objective: To investigate the dynamic changes of soluble fms-like tyrosine kinase−1 (sFlt−1), placental growth factor (PlGF) and their ratio in maternal plasma, from preeclampsia diagnosis to postpartum, evaluating its clinical utility. Methods: Single-center prospective longitudinal cohort study with repeated sample collection in women with established preeclampsia (PE). Seventy-five (n = 75) wom

Preconception health status, especially of women, but also of men, is known to influence pregnancy outcomes. Despite knowledge of the growing importance of preconception health, numerous challenges remain for conducting research in this population and delivering appropriate clinical care. The 2023 Global Pregnancy Collaboration annual workshop focused on exploring preconception health as it relate

Humanitarian aid has long been characterized as a top-down, centrally driven enterprise. Recently, this has begun to change through the broad concept of localization, which commonly describes the empowerment of national and local actors. This chapter showcases the range of localization views within humanitarian aid, focusing on terminology, various definitions and three main interpretations. It al

Slope stability is an important aspect in the management of civil engineering projects. The stability of earth slopes is a significant concern for safety and the economy. There are several methods for finding the safety factor. Spencer's method is considered one of the most accurate methods for calculating the factor of safety but it depends on the others on dividing the slope geometry into the nu

Biopharmaceuticals are complex biological molecules that require careful storage and handling to ensure medication integrity. In this study, a work system analysis of real-world protein drug (PD) handling was performed with the following goals: identify main barriers and facilitators for successful adherence to accepted recommendations in PD handling, analyse differences in two organizations, and

OBJECTIVES: Sedation and neuromuscular blockade protocols in patients undergoing targeted temperature management after cardiac arrest address patient discomfort and manage shivering. These protocols vary widely between centers and may affect outcomes. DESIGN: Consecutive patients admitted to 20 centers after resuscitation from cardiac arrest were prospectively entered into the International Cardia

BACKGROUND: The melanoma-specific survival (MSS) is heterogenous between stages and is highly dependent on the T stage for primary localized disease. New systemic therapies for metastatic cutaneous melanoma (CM) have been introduced since 2012 in Sweden.OBJECTIVES: To analyse the incidence and MSS time trends between 1990 and 2020 in Sweden.METHODS: Nationwide, population-based, and prospectively

Context: GH replacement in adult GH-deficient patients may cause insulin resistance, raising concerns of potential increased risk of developing diabetes mellitus (DM).Objective: Our objective was to assess DM prevalence and incidence in the international Hypopituitary Control and Complications Study (HypoCCS) surveillance database.Design and participants: GH-treated patients enrolled into HypoCCS

The implementation of circular economy strategies, such as the reuse of building materials, represents a valid opportunity for the building and construction sector to diminish the consumption of raw materials and generate revenues and, thus, to contribute to the Sustainable Development Goals 11 and 12. However, the reuse of building materials is still limited. Previous studies suggest that one rea

We present the confirmation and characterization of three hot Jupiters, TOI-1181b, TOI-1516b, and TOI-2046b, discovered by the TESS space mission. The reported hot Jupiters have orbital periods between 1.4 and 2.05 d. The masses of the three planets are 1.18 ± 0.14 MJ, 3.16 ± 0.12 MJ, and 2.30 ± 0.28 MJ, for TOI-1181b, TOI-1516b, and TOI-2046b, respectively. The stellar host of TOI-1181b is a F9IV

Recent years has seen a number of music researchers taking interest in the concept of affordances. Although interpretation of the concept varies, a common denominator is that affordances are opportunities for actions emerging between a subject and the environment. As such, it is an analytical perspective that highlights material and embodied dynamics of musical practice, dimensions central to musi

The era of urban artificial intelligences has begun. It is already difficult to imagine urban futures without artificial intelligence (AI). In this final chapter, we draw on the volume’s empirical findings to explore the repercussions of urban AI and give evidence of how the emergence of AI in cities is reshaping urban society, urban infrastructure, urban governance, urban planning and urban susta

This chapter looks at three different cases, which extend from literature to protest, to examine the multimodality of translation and translanguaging in intercultural communication. The cases include excerpts from the novel On Earth We Are Briefly Gorgeous, the graphic novel Persepolis and practices of lip-sewing among refugees, as documented in online media. They represent different communicative

The reasons why some individuals who experience trauma develop post-traumatic stress disorder (PTSD) while others do not remain poorly understood, highlighting the complex interplay of encoding-related and intrapersonal factors. This study aimed to examine factors predicting variability in trauma-related symptom development. Using a trauma-film paradigm in a healthy sample (N = 32), we investigate