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Knowing your risk factors for coronary heart disease improves adherence to advice on lifestyle changes and medication

Implementation of guidelines for coronary heart disease prevention is less optimal in clinical practice. The aim of this study was to investigate if specific knowledge (patients' knowledge about their own coronary heart disease risk factors) would correlate to their adherence as measured by self-reported lifestyle changes, reaching defined treatment goals and adhering to treatment with prescribed

Morphology, evolution and stratigraphic distribution in the Middle Ordovician conodont genus Microzarkodina

Microzarkodina is a genus of mainly Middle Ordovician conodonts that has its centre of distribution in Baltoscandia, and much less commonly occurs in southern China, Australia, Argentina and Laurentia. In Baltica a series of species, Microzarkodina russica n. sp., M. flabellum, M. parva, M. Bella, M. Hagetiana and M. ozarkodella, established themselves successfully. The succession of species range

CD27(-) CD4(+) memory T cells define a differentiated memory population at both the functional and transcriptional levels

The memory T-cell population is a heterogeneous population, including both effector cells, which exert a direct secondary immune response, and resting or intermediate cells, which serve as a reservoir and exert a possible regulatory role. To further dissect the T-cell memory population residing in the CD4(+) CD45RO(+) T-cell pool, we studied the functional properties of memory populations identifi

T-cell tolerance induced by repeated antigen stimulation: Selective loss of Foxp3(-) conventional CD4 T cells and induction of CD4 T-cell anergy.

Repeated immunization of mice with bacterial superantigens induces extensive deletion and anergy of reactive CD4 T cells. Here we report that the in vitro proliferation anergy of CD4 T cells from TCR transgenic mice immunized three times with staphylococcal enterotoxin B (SEB) (3x SEB) is partially due to an increased frequency of Foxp3(+) CD4 T cells. Importantly, reduced number of conventional C

Role of the ProteinTyrosine Phosphatase SHP-I in Interleukin-6 Regulation of Prostate Cancer Cells

BACKGROUND. Interleukin-6 (IL-6) is a multifunctional cytokine that has been implicated in the modulation of growth and progression of prostate cancer. Decreased expression of the tyrosine phosphatase SHP-1, involved in regulation of cytokine and tyrosine kinase receptor signaling, has been shown to be associated with less favorable outcome among prostate cancer patients. METHODS. Parental LNCaP c

Introduction : wicked problems require transformative capabilities

Climate change, migration, social injustice and loss of biodiversity are all examples of wicked problems that society is facing. The complexity and boundary-spanning nature of wicked problems require not only new competencies and skills, but also a different mindset. The responsibility of higher education is to ensure that the young people we educate are equipped with the knowledge, competencies a

Suicidal Communication Prior to Suicide in Children and Young Adults—A Medical Records Review in Health Care Services in Sweden

Suicide among children and young adults is a leading cause of mortality, highlighting the importance of the development of life-saving interventions. This study is part of the nationwide study Retrospective investigation of health care utilization of individuals who died by suicide in Sweden in 2015, Lund University, Sweden. The aim was to gain a better understanding of verbal suicidal communicati

Effect of Deformation Speed on Stress Corrosion and Fracture Toughness of Extruded Mg10Dy and Mg10Dy1Nd Using C-Ring Tests

The influence of the deformation speed in C-ring tests in Ringer's solution on crack initiation and propagation of extruded Mg10Dy and Mg10Dy1Nd is investigated. Deformation speeds varying from 2 to 0.012 mm/min allow corrosion times from a few minutes to hours. Both the crack initiation force (higher for Mg10Dy1Nd) and displacement (higher for Mg10Dy) increase with decreasing deformation speed up

Just another word? Jurisdiction in the roadmaps of state responsibility and human rights

Introduction Freedom’s just another word for nothing left to lose… Kris Kristofferson Whereas thecurrent debate on holding States accountable for extraterritorial human rights violations tends to focus on ‘jurisdiction’ or related concepts (such as ‘effective control’), the analogous public international law discourse on State responsibility appears to take a different path, managing to cope witho

Wage Earners, Taxpayers or Everyman Capitalists? : The Making of a Mutual Fund Culture in Sweden

This chapter explains how a mutual fund culture, which strengthened the link between households and the stock market, emerged exceptionally early in Sweden. We explore the popularisation of individual shareholding through state-subsidised fund savings schemes, the Tax Funds (introduced by the centre-right government in 1978) and the similar Everyman’s Funds (introduced by the Social Democratic gov

Probabilistic ODE Solvers for Integration Error-Aware Numerical Optimal Control

Appropriate time discretization is crucial for real-time applications of numerical optimal control, such as nonlinear model predictive control. However, if the discretization error strongly depends on the applied control input, meeting accuracy and sampling time requirements simultaneously can be challenging using classical discretization methods. In particular, neither fixed-grid nor adaptive-gri

Automated protein identification by the combination of MALDI MS and MS/MS spectra from different instruments

The identification of proteins separated on two-dimensional gels is most commonly performed by trypsin digestion and subsequent matrix-assisted laser desorption ionization (MALDI) with time-of-flight (TOF). Recently, atmospheric pressure (AP) MALDI coupled to an ion trap (IT) has emerged as a convenient method to obtain tandem mass spectra (MS/MS) from samples on MALDI target plates. In the presen

Unpacking (Ir)regular Labour Migration

This chapter unpacks the complex and contested nature of ‘irregular labour migration’ and explores the meaning and analytical rigour of this conceptualisation. We discuss four social positions: 1) authorised migrant regular worker, 2) authorised migrant irregular worker, 3) unauthorised migrant irregular worker and 4) unauthorised migrant regular worker. Using the distinctions between informalisat