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Estimation of the glomerular filtration rate in children and young adults by means of the CKD-EPI equation with age-adjusted creatinine values

The CKD-EPI creatinine-based estimation equation for glomerular filtration rate (GFR) cannot be used in children, overestimates GFR in young adults, and its combination with the KDIGO recommended pediatric CKiD (Schwartz bedside) equation causes implausible increases in estimated GFR when switching from pediatric to adult care. By establishing sex-specific creatinine growth curves for children and

Hovering flight in hummingbird hawkmoths : Kinematics, wake dynamics and aerodynamic power

Hovering insects are divided into two categories: ‘normal’ hoverers that move the wing symmetrically in a horizontal stroke plane, and those with an inclined stroke plane. Normal hoverers have been suggested to support their weight during both downstroke and upstroke, shedding vortex rings each half-stroke. Insects with an inclined stroke plane should, according to theory, produce flight forces on

A 1.7-6.4 GHz fourth-order RF filter with 1-40% fractional bandwidth in 22-nm FDSOI

The rise of 5G technology leads to a boom in the demand for widely available wireless connectivity while requiring telecommunication networks to improve spectral efficiency and deploy dynamic spectrum sharing (DSS) and carrier aggregation (CA). This imposes more stringent intermodulation test scenarios and blocking requirements on RF transceivers. In addition, they are required to be programmable

Mass spectrometry-based analysis of formalin-fixed, paraffin-embedded distal cholangiocarcinoma identifies stromal thrombospondin-2 as a potential prognostic marker

Background: Distal cholangiocarcinoma is an aggressive malignancy with a dismal prognosis. Diagnostic and prognostic biomarkers for distal cholangiocarcinoma are lacking. The aim of the present study was to identify differentially expressed proteins between distal cholangiocarcinoma and normal bile duct samples. Methods: A workflow utilizing discovery mass spectrometry and verification by parallel

A Stable Homoleptic Organometallic Iron(IV) Complex

A homoleptic organometallic FeIV complex that is stable in both solution and in the solid state at ambient conditions has been synthesized and isolated as [Fe(phtmeimb)2](PF6)2 (phtmeimb=[phenyl(tris(3-methylimidazolin-2-ylidene))borate]−). This FeIV N-heterocyclic carbene (NHC) complex was characterized by 1H NMR, HR-MS, elemental analysis, scXRD analysis, electrochemistry, Mößbauer spectroscopy,

A Wideband Balun-LNA for Sub-6-GHz 5G NR with Multi-Mode Operation in 22-nm FD-SOI

A wideband balun-LNA featuring common gate (CG) – common source (CS) noise cancelling, current reuse, and g0.8 GHz to 7.3 GHz that fulfills the requirements of sub-6 GHzm -boosting is presented. It covers frequency range from 5G new radio (NR) technology. The LNA provides balanced output for identical differential loads and employs forward body biasing for linearity improvement. The LNA has low se

Applying Machine Learning to Gaze Data in Software Development: a Mapping Study

Eye tracking has been used as part of software engineering and computer science research for a long time, and during this time new techniques for machine learning (ML) have emerged. Some of those techniques are applicable to the analysis of eye-tracking data, and to some extent have been applied. However, there is no structured summary available on which ML techniques are used for analysis in diff

Improving Machine Learning 30-Day Mortality Prediction by Discounting Surprising Deaths

BACKGROUND: Machine learning (ML) is an emerging tool for predicting need of end-of-life discussion and palliative care, by using mortality as a proxy. But deaths, unforeseen by emergency physicians at time of the emergency department (ED) visit, might have a weaker association with the ED visit.OBJECTIVES: To develop an ML algorithm that predicts unsurprising deaths within 30 days after ED discha

Prescription of pain medication among older cancer patients with and without an intellectual disability : A national register study

Background: The longevity for people with intellectual disability (ID) has significantly increased in developed countries during the past decades. Consequently, the incidence of cancer is expected to increase in this group. The aim of the present study was to investigate the prescription of pain medication in older cancer patients with intellectual disability (ID) compared to older patients in the

A data-driven approach for understanding invalid bug reports: An industrial case study

Context:Bug reports created during software development and maintenance do not always describe deviations from a system’s valid behavior. Such invalid bug reports may consume significant resources and adversely affect the prioritization and resolution of valid bug reports. There is a need to identify preventive actions to reduce the inflow of invalid bug reports. Existing research has shown that m

Coulomb engineering of two-dimensional Mott materials

Two-dimensional materials can be strongly influenced by their surroundings. A dielectric environment screens and reduces the Coulomb interaction between electrons in the two-dimensional material. Since in Mott materials the Coulomb interaction is responsible for the insulating state, manipulating the dielectric screening provides direct control over Mottness. Our many-body calculations reveal the

Packaging innovation scorecard

Innovation literature shows that the characteristics of a company's innovation processes determine their performance in different areas. In this study, we adopt a general conceptual model from innovation theory and apply it to packaging innovation. This helps identify and describe subprocesses in packaging innovation and how to measure their performance. It also links the packaging innovation proc

Size fractionation of high-density polyethylene breakdown nanoplastics reveals different toxic response in Daphnia magna

Plastic litter is a growing environmental problem. Recently, microplastics and nanoplastics, produced during breakdown processes in nature, have been in focus. Although there is a growing knowledge concerning microplastic, little is still known about the effect of nanoplastics. We have showed that mechanical breakdown of high-density polyethylene (HDPE), followed by filtration through 0.8 µm filte

Initial Case Study Findings for Requirements on Work-Related Health Aspects

Most work implies the use of digital systems and tools, thus, digital technology plays a vital role in modern work environments. Even so, ergonomics and usability of IT systems and digital tools used at work are often weak, which causes work-related health problems including physical, visual, cognitive, and stress-related issues. We pose that one important reason for these types of issues is the l

Performance of the European Kidney Function Consortium (EKFC) creatinine-based equation in United States cohorts

Estimating glomerular filtration rate (GFR) is important in daily practice to assess kidney function and adapting the best clinical care of patients with and without chronic kidney disease. The new creatinine-based European Kidney Function Consortium (EKFC) equation is used to estimate GFR. This equation was developed and validated mainly in European individuals and based on a rescaled creatinine,

Proton Beam APerture MoniTor instrument design and overview for the Commissioning and Operation of ESS High Power Beam on Target

This paper presents a detector developed to protect the ESS spallation target. The detector is installed to receive a proton beam that has a peak current of 62.5 mA, an average power of 5 MW, and energy up to 2 GeV. It is designed to detect any part of the proton beam that goes outside a defined aperture, which is deemed as an errant beam condition. This detector is mainly used for machine protect

Extending working life: experiences from Sweden, 1981–2011

Population ageing is making it increasingly diffcult for countries to sustain their current levels social welfare transfers from the economically active population to the dependent elderly. To meet this challenge, the Swedish government has implemented various reforms since the 1990s aimed at reducing incentives to take early retirement. However, a critical question has emerged in response to thes

ICARUS -- An Extensible Graphical Search Tool for Dependency Treebanks

We present ICARUS, a versatile graphical search tool to query dependency treebanks. Search results can be inspected both quantitatively and qualitatively bymeans of frequency lists, tables, or dependency graphs. ICARUS also ships with plugins that enable it to interface with tool chains running either locally or remotely.