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Mouse pancreatic islets microdissected free from, or surrounded by, exocrine cells were used to study the effects of secretin and choleeystokinm-pancreozymin on insulin release. Both secretin and cholecystokinin-pancreozymin potentiated glucose-stimulated insulin release regardless of whether exocrine cells were present. The results fail to support the idea that the presence of the exocrine parenc
We formulate probabilistic numerical approximations to solutions of ordinary differential equations (ODEs) as problems in Gaussian process (GP) regression with nonlinear measurement functions. This is achieved by defining the measurement sequence to consist of the observations of the difference between the derivative of the GP and the vector field evaluated at the GP—which are all identically zero
Aims: A high intake of salt raises blood pressure and the risk of cardiovascular disease. Previous studies have reported on the association between salt intake and carotid stenosis, but the association with coronary atherosclerosis has not been reported. Therefore, this project aimed at studying the association between salt intake and both carotid and coronary atherosclerosis in a contemporary com
The Arctic has warmed more than twice the rate of the entire globe. To quantify possible climate change effects, we calculate wind energy potentials from a multi-model ensemble of Arctic-CORDEX. For this, we analyze future changes of wind power density (WPD) using an eleven-member multi-model ensemble. Impacts are estimated for two periods (2020–2049 and 2070–2099) of the 21st century under a high
The Soviet canonisation of Abai, the nineteenth-century Kazakh poet and enlightener became a problematic theme for local intellectuals in the 2010s after the Occupy Abai movement in Moscow raised concerns over the heritage of Abai as a Sovietised canon and as an independent non-Soviet thinker. In 2012 oppositional leaders in Russia occupied Abai monument in Moscow and the leader of the opposition
Objective: To systematically review the efficacy of psychological, pharmacological, and combined treatments for binge eating disorder (BED). Method: Systematic search and meta-analysis. Results: We found 45 unique studies with low/medium risk of bias, and moderate support for the efficacy of cognitive behavior therapy (CBT) and CBT guided selfhelp (with moderate quality of evidence), and modest su
The prothrombin gene G20210A mutation and the platelet glycoprotein IIIa polymorphism PlA2 have been shown to be associated with thromboembolic disease. We wondered if mutations were overrepresented in patients with central retinal vein occlusion. We studied 129 consecutive patients with a history of central retinal vein occlusion. We analysed for the prothrombin gene G20210A mutation and the plat
We use a unique source from the Swedish royal demesnes to examine the work and relative wages of women in sixteenth-century Sweden, an economic laggard in the early modern period. The source pertains to workers hired on yearly contracts, a type more representative of historical labour markets than day labour on large construction sites, and this allows us to observe directly the food consumed by w
The incredible thing with blood stem cells, also known as hematopoietic stem cells (HSC), is that they can restore normal hematopoiesis in patients that need a new blood system. Since a prerequisite for successful transplantation is immune compatibility, it requires large donor registries to find a suitable match for a recipient. Unfortunately, there is still a shortage of immune-compatible donors
In 2016, the Norwegian government initiated an extensive reform of the regional scale, eventually reducing the number of political-administrative counties from nineteen to eleven through mergers. The territorial and institutional changes that followed can be understood as a partial regional (de/re)institutionalisation process, in which the political and administrative boundaries of the merged coun
Understanding biodiversity patterns poses a persistent challenge due to the complex interconnections of ecological and evolutionary processes. The particular difficulty comes from the various processes influencing biodiversity patterns across different spatial scales. This thesis aims to enhance comprehension of community diversity patterns by employing theoretical models that are capable of gener
Online Raman scattering and in situ extinction measurement were combined in this work for qualitative and quantitative evaluations of various soot in the aerosol phase with different organic compounds.
Linking clinical multi-omics with mechanistic studies may improve the understanding of rare cancers. We leverage two precision oncology programs to investigate rhabdomyosarcoma with FUS/EWSR1-TFCP2 fusions, an orphan malignancy without effective therapies. All tumors exhibit outlier ALK expression, partly accompanied by intragenic deletions and aberrant splicing resulting in ALK variants that are
Shopping centres are products and indicators of consumerism. In the case of Israel/Palestine, where shopping malls have spread since the mid-1980s, they have acquired political meanings beyond the widespread conception of consumer-choice-as-freedom, as they also claim to advance coexistence in a context marked by ethnic segregation. We perceive shopping centres as ‘non-places’, following the work
This chapter explores the history of emblems, which appear on a broad spectrum between printed literature, visual art, and material culture. Starting from Andrea Alciato’s Emblematum liber of 1531, the chapter explores multiple approaches on how emblems can be understood in the context of other multimodal media types such as insignia, badges, epigrams, hieroglyphs, and visual artifacts. Differenti
Low-and-middle-income countries (LMICs) bear a high burden of intimate partner violence (IPV). However, there are no reviews assimilating the factors affecting risk of IPV in LMICs. This systematic review (2010–20) identifies risk and protective factors of IPV in LMICs. We followed the PRISMA guidelines to review 399 studies and included 32 studies. Studies were of ever-partnered women living in a
