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Background Abiraterone acetate (AA) prolongs survival in metastatic castration-resistant prostate cancer (mCRPC) patients. To measure treatment response accurately in bone, quantitative methods are needed. The Bone Scan Index (BSI), a prognostic imaging biomarker, reflects the tumour burden in bone as a percentage of the total skeletal mass calculated from bone scintigraphy. Objective To evaluate

Background Bothgenetic and lifestyle factors contribute to the risk of type 2 diabetes, but the extent to which there is a synergistic effect of the 2 factors is unclear. The aim of this study was to examine the joint associations of genetic risk and diet quality with incident type 2 diabetes. Methods and findings We analyzed data from 35,759 men and women in the United States participating in the

Assessing the causal effects of individual dietary macronutrients and cardiometabolic disease is challenging owing to the complexity to distinguish direct effects from those mediated or confounded by other factors. To estimate these effects, intake of protein, carbohydrate, sugar, fat, and its subtypes were obtained using food frequency data derived from a Swedish population-based cohort (n~60,000

It is common for a system integrator to make use of third party intellectual property (IP) blocks from multiple vendors in the design of a circuit. These IPs may include test features, known as instruments, which are connected to a reconfigurable scan network, such as an IEEE Std. 1687 (IJTAG) network, for efficient on-chip integration and communication.Using third party instruments this way becom

Semiconductors use on-chip components, referred to as instruments, for test, debugging, firmware programming, configuration and other important functions. The instruments are needed to ensure proper device operation, however, they may be exploited by an adversary in an attack. With many different actors involved in semiconductor development and manufacturing, it becomes important to restrict acces

Tool-based code review has been an established software engineering practice for at least a decade. However, while software development environments have improved significantly during this time with advanced features for code comprehension, refactoring, and AI support, code review tools have remained more static and are still centered around a two-way textual diff view with features similar to whe

Code review is a well-established and valued practice in the software engineering community contributing to both code quality and interpersonal benefits. However, there are challenges in both tools and processes that give rise to misalignments and frustrations. Recent research seeks to address this by automating code review entirely, but we believe that this risks losing the majority of the interp

BACKGROUND: Atrial fibrillation (AF) is suggested to be associated with venous thromboembolism (VTE) and might thereby play a role in the development of chronic thromboembolic pulmonary hypertension (PH). By elevating left-sided filling pressure and promoting atrial myopathy, AF may also play a role in the development of postcapillary PH. We aimed to investigate the association between AF, with or

Motivationen med studien var den alldeles för höga stråldosen som används vid CTundersökningar. I de allra flesta fallen anpassas man inte rörströmmen efter patientens storlek och därmed får smalare patienter en onödigt hög stråldos. Målet var att reducera stråldosen till patienter som undersöks med datortomografi utan att minska på bildkvalité, genom att anpassa rörströmmen efter patientens stoIn this study we have investigated the possibilities of dose reduction in CT at a constant level of image quality by adjustment of the tube current to the phantom size. The motivation with the study is the high radiation doses to the patients and the increasing frequency of CT examinations and the variety of examinations in CT, and that the same tube current is used for different patient sizes. Ac

Denna uppsats undersöker de sedvanerättsliga reglerna om immunitet för statschefer och andra högt uppsatta statsrepresentanter. Syftet är att göra en övergripande kartläggning av reglernas innehåll som möjliggör korrekt rättstillämpning i framtiden. Genom att granska konventioner, kodifieringar, rättsfall och doktrin om ämnet, samt genom att undersöka det pågående kodifikationsarbetet, kartläggs rThis essay examines the rules of immunity for heads of state and other high-ranking state officials under international law. The aim is to create a comprehensive outline of the content of the rules, enabling a more accurate and legal-ly sound practice in the future. Through reviewing conventions, codifications, legal cases and legal doctrine on the subject, and through examining the current codi

Introduction: Alcohol use has significant health implications, yet the association between alcohol use and respiratory symptoms remains relatively understudied. This study examines the prevalence of hazardous alcohol use and its associations with breathlessness, chronic cough, and health-related quality of life (HRQoL) and whether these associations with chronic airway limitation (CAL) differ by a

Background: The routine use of sedation and analgesia during post-cardiac arrest care and its association with clinical outcomes remain unclear. This study aimed to describe the use of sedatives and analgesics in post-cardiac arrest care, and evaluate associations with good functional outcome, survival, clinical seizures, and late awakening. Methods: This was a post hoc analysis of the TTM2-trial,

Introduction Ischaemia-reperfusion (I/R) injury remains a major challenge in heart transplantation, with mortality risk increasing significantly when allograft ischaemic time exceeds 4 hours. Non-ischaemic heart preservation (NIHP), using continuous hypothermic perfusion, has shown promise in preliminary studies for reducing I/R injury and improving outcomes. This randomised controlled trial aims

Background and objective: Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is an evolving diagnostic tool for prostate cancer. There is a need to harmonise existing guidelines and reporting recommendations for PSMA PET/CT. The Standardised PSMA PET/CT Analysis and Reporting Consensus (SPARC) project aims to consolidate classifications and recommen

Feasibility of the promising large intelligent surface (LIS) concept, as well as its scalability, relies on the use of low-cost hardware components, raising concerns about the effects of hardware distortion. We analyze LIS systems with receive-chain (RX-chain) hardware distortion, showing how it may limit performance gains when scaling up these systems. In particular, using the memory-less polynom

I artikeln presenterar forskarna Tillsammans-projektet, som syftar till att förbättra socialt stöd genom samverkan mellan civilsamhället och vården. Projektet bygger på community connector-modellen, där en samhällskontakt agerar som mellanhand för att koppla patienter till stöttande resurser. Modellen, som utvecklats genom workshops, strävar efter att skapa ett mer omfattande stöd utanför vården, I artikeln presenterar forskarna Tillsammans-projektet, som syftar till att förbättra socialt stöd genom samverkan mellan civilsamhället och vården. Projektet bygger på community connector-modellen, där en samhällskontakt agerar som mellanhand för att koppla patienter till stöttande resurser. Modellen, som utvecklats genom samskapande workshops, strävar efter att skapa ett mer omfattande stöd utan