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Intravesical inoculation of gram negative bacteria or isolated bacterial products into mice induces an IL-6 response which can be measured within miutes of the infection.1,2 In such infections, IL-6 is initially detected in the urine and subsequently in the serum. Similar IL-6 responses were found in human patients deliberately colonized in the urinary tract with E. coli Hu7343. IL-6 was secreted

The purpose of this article is to empirically investigate the present state of the performance measurement systems (PMS) at 7 sites of 6 different large Swedish manufacturing companies. The methodology has both a bottom-up and a top-down perspective. Important findings are that the PMSs are very similar in how they function but differ a lot in what is measured.

During bacterial infections at mucosal sites, neutrophils migrate to the mucosa and cross the epithelial barrier. We have examined neutrophil migration across Escherichia coli-stimulated uroepithelial cell layers in an attempt to more fully understand this process. Stimulation of uroepithelial cells with E. coli or interleukin-1α (IL-1α) induced transepithelial neutrophil migration in a time- and

We present a theoretical analysis of a recent experiment [J. Opt. Soc. Am. B 6, 1513 (1989)] on two-color threephotonionization of Xe through resonant even-parity Rydberg states. We calculate second-order ac-Stark shifts, two-photon Rabi frequencies, and ionization widths by using wave functions obtained from a multichannel quantum-defect-theory analysis of the Rydberg series in Xe. We perform a d

‘Visibility’ is a concept often used in EU terminology as a means to advancing the EU’s reputation and standing in the world. Projections of EU visibility reveal changing conditions for international recognition where being seen is highly valued. This chapter examines the link between EU foreign policy, digitalization and public diplomacy, and especially the role of visibility in European Union (E

This chapter examines a population of third language (L3) learners that has received little attention, namely heritage speaker (HS) L3 learners, who grow up speaking two languages in early childhood. Unlike traditionally studied L3 learners, who acquired their L2 as older children, HSs have two naturalistically acquired languages to draw from, which has been suggested to have implications for L3 a

In this interview, Prince Sisowath Thomico, a cousin of Cambodian King Sihamoni who has been politically active in a range of political movements and parties, discusses the role of the monarchy and what royalism might mean in Cambodia today, three decades after the Cambodian monarchy was reintroduced. He reflects on the historical trajectory of the Cambodian monarchy and royalism, and analyses how

Patent Law is a legal field designed to promote technological innovation. Patent rights ensure exclusivity of rights to commercialize and explore innovation and in this sense are a fundamental mechanism to attract investment, ensure revenue streams and foster innovation. The relative relevance of patent rights depends on sectors of activity, business models and the nature of both the underlying in

Organ-on-a-chip devices are predominately made of the polymer polymethylsiloxane (PDMS), exhibiting several attractive properties e.g., transparency, gas permeability, and biocompatibility. However, the attachment of cells to this polymer has proven challenging, especially for delicate primary cells e.g., small intestinal organoid-derived epithelial cells. Hence, a need to functionalize and coat t

The 2022 EU Directive on Adequate Minimum Wages aims to ensure adequate minimum wages and strengthen collective bargaining in order to reduce in-work poverty and wage inequality. The national transposition and implementation of the Minimum Wage Directive will be heavily shaped by the existing collective bargaining and minimum wage regimes in the 27 EU Member States. To monitor and understand the p

The human host defense peptide LL-37 influences double-stranded RNA signaling, but this process is not well understood. Here, we investigate synergistic actions of LL-37 and synthetic double-stranded RNA (poly I:C) on toll-like receptor 3 (TLR3) expression and signaling, and examine underlying mechanisms. In bronchial epithelial BEAS-2B cells, LL-37 potentiated poly I:C-induced TLR3 mRNA and prote

The diverse gut microbiota, which is associated with mucosal health and general wellbeing, maintains gut-associated lymphoid tissues (GALT) in a chronically activated state, including sustainment of germinal centers in a context of high antigenic load. This influences the rules for B cell engagement with antigen and the potential consequences. Recent data have highlighted differences between GALT