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Constructing in rock will always involve unforeseen rock conditions. This involves a large risk to a project and can in the end entail delays and extra costs. To minimize the risks, an optimized pre-investigation program has to be conducted where essential information is gathered in order to make the best decisions throughout the construction project. In this work the main focus has been on the ap
Objectives: Medial meniscal body extrusion ≥ 3 mm on MRI is often considered “pathologic.” The aims of this study were to (1) assess the adequacy of 3 mm as cut-off for “pathological” extrusion and (2) find an optimal cut-off for meniscal extrusion cross-sectionally associated with radiographic knee osteoarthritis, bone marrow lesions (BMLs), and cartilage damage. Methods: Nine hundred fifty-eight
Hypertension is considered the major modifiable risk factor for the development of cognitive impairment. Because increased blood pressure is often accompanied by an activation of the immune system, the concept of neuro-inflammation gained increasing attention in the field of hypertension-associated neurodegeneration. Particularly, hypertension-associated elevated circulating T-lymphocyte populatio
The development of business ecosystems in smart cities is currently hampered by the absence of established approaches for facilitating long-term value and sustainability. In our view, the underlying reason is the lack of collective action involving various organizations in the design process. Collective action for the good of the whole ecosystem does not take place in existing participatory practi
III-Nitride (III-N) materials are promising building blocks of optoelectronic devices such as light emitting diode and laser diode due to the unique material properties. Furthermore, direct and tunable band gaps of III-N materials enable them to cover the entire visible-UV region of electromagnetic spectrum for device applications. Even though the possibility of the fabrication of many devices bas
In order to improve curve safety, warning signs are used to alert drivers to unexpected changes in horizontal alignment and speed variations. While all countries have standards and guidelines for signs, markings and delineations to ensure a uniform system, they do not use them in the same way and choices and combinations may differ. SAFESTAR project promoted a method for establishing uniform curve
This article presents new evidence on the efforts of states to collect and process information about themselves, their territories, and their populations. We compile data on five institutions and policies: the regular implementation of a reliable census, the regular release of statistical yearbooks, the introduction of civil and population registers, and the establishment of a government agency ta
Europe is building its Open Science Cloud; a set of robust and interoperable e-infrastructures with the capacity to provide data and computational solutions through cloud-based services. The development and sustainable operation of such e-infrastructures are at the forefront of European funding priorities. The research community, however, is still reluctant to engage at the scale required to signa
Background Whole-genome sequencing (WGS) of heart transplant recipient- and donor-derived cardiac biopsies may facilitate organ matching, graft failure prediction, and immunotolerance research. The objective of this study was to determine the feasibility of WGS based on formalin-fixed paraffin-embedded endomyocardial biopsies. Methods and results The study included serial donor- and recipient samp
The release of insulin in vitro from isolated mouse islets was significantly inhibited in the presence of an islet protein extract equivalent to more than 100 times the normal serum level of insulin. The nature of the inhibitory islet substance remains unclear. The possibility that the blood circulation through the islets may be important for the local regulation of insulin release by reducing hig
Eukaryotic genomes, particularly animal genomes, have a complex, nonuniform, and nonrandom internal compositional organization. The compositional organization of animal genomes can be described as a mosaic of discrete genomic regions, called "compositional domains," each with a distinct GC content that significantly differs from those of its upstream and downstream neighboring domains. A typical a
The formation of cold gas giants similar to Jupiter and Saturn in orbit and mass is a great challenge for planetesimal-driven core accretion models because the core growth rates far from the star are low. Here we model the growth and migration of single protoplanets that accrete planetesimals and gas. We integrated the core growth rate using fits in the literature to N-body simulations, which prov
Huntington's disease (HD) is a fatal genetic neurodegenerative disorder. It has mainly been considered a movement disorder with cognitive symptoms and these features have been associated with pathology of the striatum and cerebral cortex. Importantly, individuals with the mutant huntingtin gene suffer from a spectrum of non-motor features often decades before the motor disorder manifests. These sy
Ultrashort laser pulses have become an indispensable tool in physics, chemistry and engineering. Their numerous applications call for accurate and robust characterization techniques able to reliably retrieve the pulse's intensity profile. Different methods, such as FROG [1] or SPIDER [2] and their variants, have been developed in past decades and are now common in many laboratories. More novel app
Because of their important role in civil society, charities are often granted a special status in national tax legislation. Many charities initiate activities abroad and come in the realm of EU law, for example, because of cross border investments, fundraising activities and competition with foreign charities. Tax legislation for charities is, however, not harmonized in the EU and varies widely. E
