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Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous proble

Aim: Children born extremely preterm frequently have developmental coordination disorder (DCD). We aimed to evaluate perinatal risk factors for DCD. Methods: Swedish national cohort study including 226 children born before 27 gestational weeks without major neurodevelopmental disabilities at 6.5 years. Outcome was DCD, defined as ≤5th percentile on the Movement Assessment Battery for Children-Seco

Purpose: The number of childbirths among cancer survivors continues to increase, but it is still largely unknown whether the children of cancer survivors might experience adverse health outcomes during the process of growing up. Methods: We identified all individuals diagnosed with cancer between 1958 and 2015 from the Swedish Cancer Registry and linked them to the Swedish Medical Birth Register t

Recent evidence suggests that cholera toxin might have multiple functions regarding the ability to regulate the immune system. However, it is unknown whether subsequent administration of cholera vaccine might affect the mortality rate in patients with prostate cancer. Here we report that patients in Sweden, who were diagnosed with prostate cancer between July 2005 and December 2014 and used choler

Background: Most validations of paediatric glomerular filtration rate (GFR) estimating equations using standardized creatinine (CR) and cystatin C (CYS) assays have comprised relatively small cohorts, which makes accuracy across subgroups of GFR, age, body mass index (BMI) and gender uncertain. To overcome this, a large cohort of children referred for GFR determination has been established from se

Background: Acquired loss of the largest von Willebrand factor multimers is a common hemostatic disturbance in patients with aortic valve stenosis (AS), resulting in impaired platelet adhesion and increased bleeding risk. AS is also associated with atherosclerosis and myocardial infarction (MI). Our aim was to study the clinical outcomes associated with AS in MI patients treated with dual antiplat

Background & Aims Cholera toxin can act as a modulator of the immune response with anti-inflammatory effects; it reduces development of colon polyps in mouse models of colorectal cancer (CRC). We performed a population-based study to determine whether, in patients with a diagnosis of CRC, subsequent administration of the cholera vaccine (killed Vibrio cholerae O1 whole cells and recombinant ch

To understand the developmental trajectories in early lymphocyte differentiation, we identified differentially expressed surface markers on lineage-negative lymphoid progenitors (LPs). Single-cell polymerase chain reaction experiments allowed us to link surface marker expression to that of lineage-associated transcription factors (TFs) and identify GFRA2 and BST1 as markers of early B cells. Funct

Increased risks of certain cancers have been observed in patients with hepatitis C virus (HCV) infection. However, data on other cancer sites/types are lacking. We analyzed systematically the risk of developing 35 common cancers in patients with HCV infection using a nationwide Swedish database. Patients with HCV infection were identified from the Swedish Hospital Inpatient and Outpatient Register

In 2003, the Kimberley Process, a public-private partnership gathering governments, the diamond industry and several civil society organizations, entered into force. This international scheme, aiming at fighting against conflict diamonds, imposed export bans on diamonds from the Marange Fields in the Eastern part of Zimbabwe and from the Central African Republic. Indeed, evidence of violations of

Despite a relatively highly institutionalized and developed policy field, the EU environmental legislation suffers from a persistent implementation deficit. Although the challenges concern the supranational actors of the EU as well, the academic focus has been on the Member State level and in attempts explaining the challenges the national authorities face while implementing the EU environmental l

7 miljoner människor dör varje år på grund av cigarrettrökning. Idag finns det flera olika produkter på marknaden som kan hjälpa personer att sluta denna dåliga vana. Den första var Nicorette® tuggummin. När McNeil AB producerar Nicorette® tuggummin, följer McNeil de strikta kraven på kvalité som de regulatoriska myndigheterna kräver. Dessa krav tvingar McNeil att slänga tonvis av tuggummin varje McNeil AB produces pharmaceutical chewing gums that contains nicotine. Since this smoking cessation product is a pharmaceutical, the regulatory agencies demand that any gums outside pre-set specifications are discarded. Some batches have more discarded material than others, due to the variability in the manufacturing process. By analysing this variability, the personnel could make choices that low

Bosnia-Herzegovina and Northern Ireland are similar in many ways. Both cases have experienced wars that left the people fragmented and traumatized. But one aspect that separates them is their peace processes. In Bosnia, a peace deal was brokered after three months of intense negotiations. In Northern Ireland, it took two years for an agreement to be reached. Furthermore, both post-war Bosnia and N

Inom nuvarande forskning om Internet of Things (IoT) finns det inte många studier som har tittat på användarperspektivet eller på hur företag som är verksamma inom IoT avväger användarupplevelse när de utvecklar IoT-produkter. Syftet med denna studie är att undersöka hur användarupplevelsen tas hänsyn till under utvecklingsprocessen för IoT. Den syftar också till att undersöka i vilken utsträckninIn current research of Internet of Things (IoT), there is limited research on the user perspective and even less on how companies operating in the field consider User Experience (UX) when developing for IoT. The aim of this thesis is to investigate how UX is considered during the development process of IoT. It also includes exploring to which extent this is done with a data-driven approach. The st

The study aims to develop a deeper understanding of how transformational changes can affect employees’ creative process engagement. By conducting a single case study at a technology organization that has been undergoing several transformational changes over the last decade, we have tried to reach our aim. Adopting an interpretive approach, we have investigated our research problem by conducting se

Robotic Process Automation är en teknologi som växt fram under de senaste åren som ett framgångs- rikt sätt göra kostnadsbesparingar. Flera företag har påbörjat införanden av RPA men det är inte helt problemfritt och flera projekt misslyckas. Utmaningar kopplat till vad som bör automatiseras, var RPA ska ligga i organisationen och hur man hanterar förändringsmotstånd är några av de aspekter som ka

The observed and expected changes in the environment due to human actions implies risks that future food production will be insufficient. Pre- dicting the impact these changes have on the agricultural system could be beneficial by allowing for proactive mitigating efforts. The prediction of these impacts often involve large computer programs that simulate the behavior of the environment. By implem

Based on data from the past, predictive analytics can give a competitive advantage for companies when it is used to forecast the future. Specifically, predictive analytics can be used to aid decision makers in strategic planning. As the construction industry faces challenges with both more costly and complicated projects, predictive analytics can support decision makers in the industry in the most