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Malignant melanoma is a very aggressive skin cancer, characterized by a heterogeneous nature and high metastatic potential. The incidence of melanoma is continuously increasing worldwide, and it is one of the most common cancers in young adults. In the past twenty years, our understanding of melanoma biology has increased profoundly, and disease management for patients with disseminated disease ha
Life on Earth was sharply disrupted 66 Ma ago as an asteroid hit the sea-floor in what is today Yucatan Peninsula, Mexico. Approximately 600 km(3) of sedimentary rock were vapourized, ejected into the atmosphere and subsequently deposited globally as an ejecta apron and fallout layer. Proximal ejecta deposits occur in Belize and southern Mexico where the so called Albion island spheroid bed is sup
Fission track analysis (FTA) was developed to be applied to ultra-low levels of 239Pu in bioassay samples. An analytical protocol was established for the FTA processing. The detection limit was determined to 1.5 µBq and the calibration constant was 24 fission fragments per µBq 239Pu. Naturally occuring nuclides of thorium and uranium, present in biological and environmental samples, did not interf
The modern medical treatment of HIV with antiretroviral therapy (ART) has drastically reduced the morbidity and mortality in patients infected with this virus. ART has also been shown to reduce the transmission risk from individual patients as well as the spread of the infection at the population level. This position statement from the Public Health Agency of Sweden and the Swedish Reference Group
A search for a new resonance decaying to a W or Z boson and a Higgs boson in the [Formula: see text] final states is performed using 20.3 fb[Formula: see text] of pp collision data recorded at [Formula: see text] 8 TeV with the ATLAS detector at the Large Hadron Collider. The search is conducted by examining the WH / ZH invariant mass distribution for a localized excess. No significant deviation f
To provide a basis for the interpretation of past climatic conditions from Quaternary leaf records, leaf carbon isotope (delta C-13) results are presented for 12 northern European dwarf-shrub, shrub and tree species growing across a network of 18 sites in northern Scandinavia. The role of micro-habitat (hummock/hollow) on carbon isotope trends is explored in addition to a comparison of the carbon
Two major events marked 2002 as a milestone year for the sustainable development agenda and in particular for the tourism sector. The declaration by the United Nations of 2002 as ‘International Year of Ecotourism’ (IYE), culminated in the organisation of the World Ecotourism Summit (WES) in May 2002. This was followed in August 2002 by the World Summit for Sustainable Development (WSSD), a global
Antibodies are critical entities used for the protection of an individual organism against infection and disease. Through a complex series of events genes rearrange to encode repertoires of molecules, which are tested for their ability to identify foreign molecules. In this report, we discuss factors defined by the individual as well as by infectious organisms that shape the antibody repertoire. A
OBJECTIVE: To define a minimum Standard Set of outcome measures and case-mix factors for monitoring, comparing, and improving healthcare for patients with clinically diagnosed hip or knee osteoarthritis (OA) with a focus on defining the outcomes that matter most to patients. METHODS: An international Working Group (WG) of patients, arthroplasty register experts, orthopedic surgeons, primary care
Visual observations of Perseid meteors carried out in 1953-83 at the Onsala Space Observatory are analyzed to study the fine structure of the Perseid meteor stream maximum. Observed hourly rates are corrected for weather conditions and to a zenithal value. The Perseid activity curve is studied (1) for all observed Perseids, (2) for Perseids of app. magnitude 2.0 or brighter. The activity curve for
The envelope process is an analytical tool often used to study extremes and wave groups. In an approach to approximate the first passage probability for the underlying response the average number of envelope crossings is used to obtain an upper bound. In the first part of the paper, we review the approach as well as give a brief account of the previous results with some focus on the contribution
Angiogenesis is a key event in cancer progression and therefore a promising target in cancer treatment. Galectin-1, a β-galactoside binding lectin, is up-regulated in the endothelium of tumors of different origin and has been shown to be the target for anginex, a powerful anti-angiogenic peptide with anti-tumor activity. Here we show that when bound to anginex, galectin-1 binds various glycoprotei
This thesis investigates media coverage of the 2024 European Parliament election in Sweden, Finland, and Denmark, analyzing the extent to which media addressed voter priorities as identified in the Eurobarometer survey and exploring emerging themes. Through qualitative content analysis of 276 headlines from nine major newspapers, the study reveals significant variations in media engagement across
The equivalence of the sine-Gordon model and the massive Thirring model, (1+1) dimensional theories of a single scalar field respectively a single Dirac field, is derived by two alternative approaches. The equivalence is derived by a comparison of the perturbation expansions of the correlation functions of the theories around the corresponding massless theories. The alternative derivation of the e
