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Disturbed haemostasis is a central finding in severe Streptococcus pyogenes infection. In particular, microthrombi are found both at the local site of infection and at distant sites. Platelets are responsible for maintaining vascular function and haemostasis. We report here that M1 protein of S. pyogenes triggers immune-mediated platelet activation and thrombus formation. M1 protein is released fr

This study explores author texts on public libraries in the United Kingdom between the years 2010 and 2018. The texts appear in a national public debate about the value, purpose and direction of the library service following a significant number of library closures and funding cuts. These were the result of the global financial crisis of 2007 and 2008 and the subsequent implementation of the auste

Purpose: The aim of this thesis is to explore the transition towards a hybrid work model and the implications it may have on the use and adaptation of management control within PSFs. The purpose is further to highlight the reasons behind the adaptations of MCS. Methodology: A qualitative single case study of a professional service firm, with empirical data collected through semi-structured interv

Fragmentation, as one of the most distinct characteristics of agricultural landscapes worldwide, has resulted in a diversity of ecological consequences. It remains as a gap in the literature on how provisioning service changes in association with agricultural fragmentation and land use management. Addressing such a gap at a national level should provide essential insights for policymakers. This pa

Background: Metabolic positron emission tomography/computed tomography (PET/CT) parameters describing tumour activity contain valuable prognostic information, but to perform the measurements manually leads to both intra- and inter-reader variability and is too time-consuming in clinical practice. The use of modern artificial intelligence-based methods offers new possibilities for automated and obj

OBJECTIVES: To evaluate how radiographic damage, overall and measured as joint space narrowing score (JSNS) and erosion score (ES), as well as other clinical and laboratory measures, relate to disability and pain in early rheumatoid arthritis (RA).METHODS: An inception cohort of 233 patients with early RA, recruited in 1995-2005, was followed for 5 years. Disability was assessed with the Health As

BACKGROUND: Recent studies have reported that reduced-dose trimethoprim-sulfamethoxazole (TMP-SMX) may be effective in the treatment of Pneumocystis jirovecii pneumonia (PJP), but data are lacking for patients with hematologic malignancies.METHODS: This retrospective study included all adult hematologic patients with PJP between 2013 and 2017 at 6 Swedish university hospitals. Treatment with 7.5-1

Aims/hypothesis: Low birthweight is a risk factor for type 2 diabetes and CVD. This prospective cohort study investigated whether lower birthweight increases CVD risk after diagnosis of type 2 diabetes. Methods: Original midwife records were evaluated for 8417 participants recently diagnosed with type 2 diabetes in the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort. Patients

Context: Even within the physiological range, serum calcium (sCa++) may influence vascular tone and blood pressure (BP); however, the potential modulatory role of dietary calcium intake remains unclear. Objective: To investigate the association between sCa2+ and BP (including central BP) and to assess whether calcium intake affects this relationship. Methods: sCa2+ was measured in patients referre

OBJECTIVES:: In a recent study hypnosis has been found to relieve persistent idiopathic orofacial pain. Quantitative sensory testing (QST) is widely used to evaluate somatosensory sensitivity, which has been suggested as a possible predictor of management outcome. The objectives of this study were to examine: (1) possible associations between clinical pain relief and baseline somatosensory sensiti

We have previously shown that expression of CD40 has a favorable prognostic impact in diffuse large B-cell lymphoma (DLBCL) after anthracycline-based chemotherapy. Here we examined the prognostic value of immunohistochemically defined CD40 expression in 95 patients with DLBCL treated with both anthracycline-based chemotherapy and rituximab. Using a 10% cut-off level, 77% of the patients had CD40-p