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Stratification of cancer into biologically and molecularly similar subgroups is a cornerstone of precision medicine. The Lund Taxonomy classification system for urothelial carcinoma aims to be applicable across the whole disease spectrum including both non–muscle-invasive and invasive bladder cancer. A successful classification system is one that can be robustly and reproducibly applied to new sam
In this symposium piece, I reply to the diverse and wide-ranging set of objections to my book (The Open Future: Why Future Contingents are All False) set forth by MacFarlane, Green, Wasserman, and Bigg & Miller.
Background: The experiences of art and music are an essential part of human life and this study aimed to examine the longitudinal association between cultural participation and coronary heart disease. Methods: This was a longitudinal study on a randomly selected representative adult cohort (n = 3296) of the Swedish population. The study period was over 36 years (1982–2017) with three separate eigh
INTRODUCTION: Assessing the potential sources of bias and variability of the Centiloid (CL) scale is fundamental for its appropriate clinical application. METHODS: We included 533 participants from AMYloid imaging to Prevent Alzheimer's Disease (AMYPAD DPMS) and Alzheimer's Disease Neuroimaging Initiative (ADNI) cohorts. Thirty-two CL pipelines were created using different combinations of referenc
Objective: The concept of proportionate and disproportionate functional mitral regurgitation suggests that transcatheter edge-to-edge mitral repair may benefit patients with a smaller left ventricle relative to a higher regurgitant burden. The clinical relevance of proportionality remains unknown in mitral operations for ischemic mitral regurgitation. We aimed to characterize the association betwe
Background: Periampullary diverticulum (PAD) is commonly encountered in endoscopic retrograde cholangiopancreatography (ERCP) procedures. Objectives: We sought to determine whether PADs are associated with a lower success rate of cannulation and an increased risk of adverse events. Design: A retrospective cohort study was conducted using prospectively gathered nationwide registry data. Methods: Us
This study investigates age-related biases in AI-generated art through a mixed method investigation of images of older and younger individuals. Employing 19 text prompts associated with social exclusion for older adults, we collected 465 images from an AI-art generator, MidJourney, and conducted quantitative and qualitative analyses to understand differences between age group depictions. We used A
Scholarship on the Jovinianist controversy has shown that the idea of baptism as deeply transformative lay at the heart of Jovinian's thinking. Scholars have likewise held that Jerome, who through his Adversus Jovinianum is our main source to the ideas of Jovinian, did not acknowledge the ecclesiological concerns on which his opponent's argument was based. This article argues, to the contrary, tha
This essay uses a microhistory of Chinese comfort women during the Asia-Pacific War to illuminate the gendered dynamics of violence and the contrasting emotions experienced by both sexually abused women and their Japanese perpetrators, forming a perpetrator-victim dyad. The essay employs the concept of intersectional emotions within a micro-historical framework to demonstrate that this violence ag
According to Jon Elster, mechanisms are frequently occurring and easily recognizable causal patterns that are triggered under generally unknown conditions or with indeterminate consequences. In the absence of laws, moreover, mechanisms provide explanations. In this paper I argue that Elster’s view has difficulties with progressing knowledge. Normally, filling in the causal picture without revising
This paper describes the research stimulated by a fundamental shift that is occurring in the manufacture and marketing of aero engines for commercial and defence purposes, away from the selling of products to the provision of services. This research was undertaken in an aerospace company, which designs and manufactures aero engines and also offers contracts, under which it remains responsible for
Automation in aerospace industry is often in the form of dedicated solutions and focused on processes like drilling, riveting etc. The common industrial robot has due to limitations in positional accuracy and stiffness often been unsuitable for aerospace manufacturing. One major cost driver in aircraft manufacturing is manual assembly and the bespoke tooling needed. Assembly tasks frequently invol
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