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Background: To examine rates of serious pneumococcal infections up to 10 years after vaccination with 7-valent conjugated pneumococcal vaccine (PCV7) in patients with arthritis compared to non-vaccinated arthritis patients.Methods: In total, 595 adult arthritis patients (rheumatoid arthritis; RA = 342, 80 % women and spondylarthropathy; SpA = 253, 45 % women) received one dose of PCV7. Mean age/di
Quaternary Asian low-latitude hydroclimate cyclicity has long been attributed to insolation forcing, in contrast to the dominant ice-sheet and CO2 controls identified in mid-high-latitude regions. However, debates exist regarding these rainfall variations and forcings due to inconsistent reconstructions and simulations. Here, by combining rainfall proxy records with multi-model simulations, domina
Context: Agri-environment schemes support land management interventions that benefit biodiversity, environmental objectives, and other public goods. Process-based model simulations suggest the English scheme, as implemented in 2016, increased wild bee pollination services to pollinator-dependent crops and non-crop areas in a geographically heterogeneous manner. Objectives: We investigated which in
Objective: Meniscal calcifications are associated with the pathogenesis of knee osteoarthritis (OA). We propose a micro-computed tomography (μCT) based 3D analysis of meniscal calcifications ex vivo, including a new grading system. Method: Human medial and lateral menisci were obtained from 10 patients having total knee replacement for medial compartment OA and 10 deceased donors without knee OA (
The photoluminescence (PL) of metal halide perovskites can recover after light or current-induced degradation. This self-healing ability is tested by acting mechanically on MAPbI3 polycrystalline microcrystals by an atomic force microscope tip (applying force, scratching, and cutting) while monitoring the PL. Although strain and crystal damage induce strong PL quenching, the initial balance betwee
1. Challenging calibration of complex models can be approached by using prior knowledge on the parameters. However, the natural choice of Bayesian inference can be computationally heavy when relying on Markov Chain Monte Carlo (MCMC) sampling. When the likelihood of the data is intractable, alternative Bayesian methods have been proposed. Approximate Bayesian Computation (ABC) only requires sampli
Sanfilippo C syndrome (Mucopolysaccharidosis IIIC) is a rare lysosomal storage disorder caused by mutations in the HGSNAT gene. It is characterized by a progressive and severe neurodegeneration, for which there is no treatment available. Here, we report the generation of two HGSNAT-mutated cell lines from a healthy human induced pluripotent stem cell (hiPSC) line using CRISPR/Cas9 editing. These n
Matola, a major Mozambican city, has witnessed flooding, mainly caused by rainfall. The study aims to produce flood-hazard and flood-risk maps for Matola using the hydrological model TFM-DYN. For 2000, 2020, and 2040, the modeled extent of medium-risk area is 50.6 km2 (13.7%), 44.8 km2 (12.2%), and 39.0 km2 (10.6%) and of high-risk area is 43.3 km2 (11.8%), 31.8 km2 (8.6%), and 28.9 km2 (7.8%), re
Background: Previous studies have reported an inverse association between educational attainment and different osteoarthritis (OA) outcomes. However, none of the previous studies have accounted for potential confounding by early-life environment and genetics. Thus, we aimed to examine the association between educational attainment and knee and hip OA surgery using twin data. Methods: From the Swed
Physical therapy and social interactions between the stroke patient and healthcare professionals or relatives facilitate the process of recovery and promote improvement of lost neurological function after stroke. These observations can be mimicked in an experimental setting by multimodal stimulation provided in the concept of enriched environment. The enriched environment is a housing condition co
Cancer is a multifactorial, complex disease exhibiting extraordinary phenotypic plasticity and diversity. One of the greatest challenges in cancer treatment is intratumoral heterogeneity, which obstructs the efficient eradication of the tumor. Tumor heterogeneity is often associated with the presence of cancer stem cells (CSCs), a cancer cell sub-population possessing a panel of stem-like properti
Very few countries have managed to decouple economic growth from resource use and greenhouse gas emissions in absolute terms and at rates to meet the climate targets of the Paris Agreement. To achieve this, technological solutions would need to be combined with sufficiency-oriented policies in a postgrowth context. This paper develops policy ideas for a sustainable welfare–work nexus via citizen e
Organic colloids are an important part of dissolved organic matter (DOM) yet many of their properties remain elusive. The main aims of this study were to assess how the colloidal properties of DOM extracted with water from an organic boreal soil horizon varied with the extraction protocol, and thereby provide insight into the nature of the DOM colloids and develop a mechanistic understanding of ho
The labour market consequences of early-onset or congenital disabilities have received little attention in the literature. In this paper, we study the consequences of cerebral palsy (CP), a lifelong early onset disability, and pathways through which it affects labour outcomes. We use data from multiple linked Swedish National Population Registers between 1990 and 2015 and apply both regression and
While wild pollinators play a key role in global food production, their assessment is currently missing from the most commonly used environmental impact assessment method, Life Cycle Assessment (LCA). This is mainly due to constraints in data availability and compatibility with LCA inventories. To target this gap, relative pollinator abundance estimates were obtained with the use of a Delphi asses
Accessible housing for the aging population is important, but large-scale reliable information on accessibility problems in ordinary housing is lacking. This study aimed to describe the prevalence of environmental barriers and analyze potential accessibility problems in the Swedish housing stock and to evaluate the validity and representativeness of housing data collected in a citizen science proj
AIMS: Parameters derived from reservoir-excess pressure analysis have been demonstrated to predict cardiovascular events. Thus, altered reservoir-excess pressure parameters could have a detrimental effect on highly-perfused organs like the heart. We aimed to cross-sectionally determine whether reservoir-excess pressure parameters were associated with N-terminal pro-brain-type natriuretic peptide (
The ring-like peripheral light-harvesting complex 2 (LH2) expressed by many phototrophic purple bacteria is a popular model system in biological light-harvesting research due to its robustness, small size, and known crystal structure. Furthermore, the availability of structural variants with distinct electronic structures and optical properties has made this group of light harvesters an attractive
Significant progress has been made in elucidating genetic risk factors influencing Type 1 diabetes (T1D); however, features other than genetic variants that initiate and/or accelerate islet autoimmunity that lead to the development of clinical T1D remain largely unknown. We hypothesized that genetic and environmental risk factors can both contribute to T1D through dynamic alterations of molecular
BackgroundThis study aimed to investigate the exposure to perfluoroalkyl substances (PFAS) and cancer-related toxicity in workers in different Swedish industry sectors with exposures to hexavalent chromium (Cr(VI)).MethodsThe study consisted of 111 exposed workers and 72 controls. The exposed workers were performing manufacture/processing of metal products (n=55), working in steel production (n=31
