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In this research, we develop three statistical based control charts: the Hotelling's T2, MEWMA (multivariate exponentially weighted moving average), and LRT (likelihood ratio test) as well as three machine learning (ML) based control charts: the ANN (artificial neural network), SVR (support vector regression), and RFR (random forest regression), for monitoring generalized linear model (GLM) profil
In this paper we develop two models; the without shortages and the completely backlogging shortages with the price dependant demand rate under time value of money and inflation, finite time horizon and exponentially deterioration rate with the objective of maximizing the present worth of the total system profit. Using the dynamic programming method for each model, we are able to obtain different s
The present paper establishes a simulation framework for modelling the deposition and solidification of steel melt in Directed Energy Deposition with a Laser Beam (DED-LB) by using the Particle Finite Element Method (PFEM). Unlike traditional finite element methods, the remeshing framework makes it possible to resolve the interaction between molten metal and substrate upon deposition, solidificati
Aims: TCF7L2 rs7903146 is the most impactful single genetic risk variant for type 2 diabetes. However, its role on disease progression, complications and mortality among people with type 2 diabetes at diagnosis remains unclear. Materials and Methods: We assessed the per allele impact of the rs7903146 T-allele on clinical characteristics and complication risk in 9231 individuals with type 2 diabete
Understanding the “fit” of models designed to predict binary outcomes has been a longstanding problem across the social sciences. We propose a flexible, portable, and intuitive metric for quantifying the change in accuracy between two predictive systems in the case of a binary outcome: the InterModel Vigorish (IMV). The IMV is based on an analogy to weighted coins, well-characterized physical syst
Lean, premixed, swirl-stabilized flames are widely used in modern Dry Low Emissions gas turbine combustors; however, the turbulent combustion process under those conditions is known to be extremely sensitive and prone to instabilities. Numerical simulations can be a valuable tool in predicting the effects of alternative fuels; however, the sensitivity of the results to different models ought to be
The objective of the EMEEES project is to assist the European Commission in developing harmonised evaluation methods. It aims to design methods to evaluate the measures implemented to achieve the 9% energy savings target set out in the EU Directive (2006/32/EC) (ESD) on energy end-use efficiency and energy services. The assistance by the project and its partners is delivered through practical advi
Idiopathic pulmonary fibrosis (IPF), an insidious disease with grave prognosis, is characterized by heterogeneous fibrosis with densely fibrotic areas surrounded by nonfibrotic normal-looking tissue, believed to reflect a temporal development. The etiology is incompletely elucidated, but aberrant wound healing is believed to be involved. Embryonic signaling pathways, including Wnt signaling, are r
OBJECTIVES: There are significant geographical differences in the prevalence and incidence of celiac disease that cannot be explained by HLA alone. More than 40 loci outside of the HLA region have been associated with celiac disease. We investigated the roles of these non-HLA genes in the development of tissue transglutaminase autoantibodies (tTGA) and celiac disease in a large international prosp
Small-angle X-ray scattering (SAXS) is an indispensable tool in structural investigations of self-assembled colloidal crystals and colloidal liquid crystals. This paper reviews recent studies of the particle shape effects on the crystal structure as revealed by SAXS. Rod-like, plate-like, biaxial board-like as well as cubic-like shapes are discussed. Since relatively large, (sub)micron particles a
For the CSR movement the challenge is broadly speaking to make responsible business practices both effective and sustainable in the long run, communicate them credibly to third parties, and institutionalise them more widely in the business community. In this article, I address three main themes where I think more clarity would enable CSR to evolve to a new level and achieve its promising potential
Proteoglycan concentrations in knee joint synovial fluid and in serum from patients with various inflammatory arthritides were studied using an enzyme-linked immunosorbent assay. Patients with reactive arthritis, calcium pyrophosphate arthorpathy, and juvenile rheumatoid arthritis (age ≤20 years) had the highest synovial fluid concentrations. These values differed significantly (P < 0.001) from th
Pretreatments are crucial to achieve efficient conversion of lignocellulosic biomass to soluble sugars. In this light, switchgrass was subjected to 13 pretreatments including steam explosion alone (195 °C for 5, 10 and 15 min) and after impregnation with the following catalysts: Ca(OH)2 at low (0.4%) and high (0.7%) concentration; Ca(OH)2 at high concentration and higher temperature (205 °C for 5,
Purpose: To study the phenotype in two families with genetically identified autosomal dominant retinitis pigmentosa (adRP) focusing on macular structure and function. Methods: Clinical data were collected at the Department of Ophthalmology, Lund University, Sweden, for affected and unaffected family members from two pedigrees with adRP. Examinations included optical coherence tomography (OCT), ful
Purpose: To quantify fixation stability in patients with neovascular age-related macular degeneration (nAMD) at baseline, 3 and 6 months after anti-vascular endothelial growth factor (anti-VEGF) treatment and furthermore asses the implications of an unsteady fixation for multifocal electroretinography (mfERG) measurements. Methods: Fifty eyes of 50 nAMD patients receiving intravitreal anti-VEGF tr
