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Objective: To assess the reliability of speech data and speech-related quality indicators in the Swedish quality registry for cleft lip and palate (CLP) at 10 years of age. Design: Retrospective study. Setting: University hospitals. Participants: One hundred twenty-one 10-year-olds with unilateral or bilateral CLP. Main outcome measures: Six independent raters reassessed audio recordings for compa
Background: Foot deformities, such as valgus and varus in the coronal plane and equinus in the sagittal plane, are common in children with cerebral palsy (CP). The purpose of this study was to describe the prevalence of coronal plane foot deformities and their association with the Gross Motor Function Classification System (GMFCS) level, age, CP subtype, and equinus in children with CP. Methods: A
Aim: To assess the prevalence of overweight among Swedish 4 year olds in 2018, 2020 and 2022, taking socioeconomic variables into account. Methods: Aggregated regional data on children's body mass index were collected. The socioeconomic Care Need Index (CNI), foreign background, low education, being a single parent, low income and childhood poverty, were assessed. The differences in overweight, in
Multiplanetary systems spanning the radius valley are ideal testing grounds for exploring the different proposed explanations for the observed bimodality in the radius distribution of close-in exoplanets. One such system is HIP 29442 (TOI-469), an evolved K0V star hosting two super-Earths and one sub-Neptune. We observed HIP 29442 with CHEOPS for a total of 9.6 days, which we modelled jointly with
Recent technologies of district heating and cooling (DHC) systems integrate renewable energy sources and connect multiple heat producers and consumers to the same network. The resulting interactions may therefore cause the fluid in the pipe, or the energy carried by the system, to flow in both directions. This article presents a newly developed analytical method for evaluating the hydraulic states
Throughout adulthood and ageing our brains undergo structural loss in an average pattern resembling faster atrophy in Alzheimer’s disease (AD). Using a longitudinal adult lifespan sample (aged 30-89; 2–7 timepoints) and four polygenic scores for AD, we show that change in AD-sensitive brain features correlates with genetic AD-risk and memory decline in healthy adults. We first show genetic risk li
Pulmonary veno-occlusive disease (PVOD) is a lethal variant of pulmonary hypertension. The degree of pulmonary arterial involvement varies. Here, we compare two PVOD patients who were transplanted at 8 years of age, whereof one is a homozygous EIF2AK4 mutation carrier. Tissue was imaged with synchrotron-based micro-CT and the results were compared with clinical data and sectioned tissue was analyz
Two anticancer gold(iii) compounds, Au2phen and Auoxo4, were encapsulated within a ferritin nanocage. The gold-compound loaded proteins were characterized by UV-Vis spectroscopy, inductively coupled plasma mass spectrometry and circular dichroism. X-ray crystallography shows that the compounds degrade upon encapsulation and gold(i) ions bind Ft within the cage, close to the side chains of Cys126.
While the Convention on the Rights of the Child (UNCRC) does not address research, it instigated a recognition that decisions concerning children and youth must be based on knowledge of their experiences from their own perspective and consider their specific views and wishes, highlighting their right to be heard. Participatory research underscores this right, arguing the engagement of children and
BACKGROUND: Heart failure (HF) is a common chronic condition that affects over 26 million people worldwide. It is a progressive and debilitating disease with a broad symptom profile, intermittently marked by periods of acute decompensation. People with HF generally do not self-manage their condition well (eg, monitoring symptoms, taking medications regularly, physical activity, etc). A better unde
The distinguishing feature of frequency diverse array (FDA) systems as compared to conventional phased-array and multiple-input multiple-output (MIMO) radar systems is the use of a small frequency offset (FO) across the array elements. Much of the development to date has focused on the FDA-MIMO structure, using an FO that is larger than the bandwidth of the baseband signal, thereby reducing the re
The concept of a socially sustainable society is linked to the notion of equal access to high-quality welfare services and an equitable distribution of common resources. The rationale behind the introduction of private actors to provide welfare services is that greater choice will result in higher quality of service for individuals, achieved through a co-creation process. The purpose of this study
Recently suggested strategies for ammonia-blended combustion promote the interest in oxygenated hydrocarbon fuels. The development of combustion models for blended fuels is challenging and the cross-reactions are critical to the performance of the models. In this work, comprehensive ab initio thermodynamic and kinetic studies targeting diethyl ether (DEE) and its cross-reactions with NH2 were carr
In this research, we develop three statistical based control charts: the Hotelling's T2, MEWMA (multivariate exponentially weighted moving average), and LRT (likelihood ratio test) as well as three machine learning (ML) based control charts: the ANN (artificial neural network), SVR (support vector regression), and RFR (random forest regression), for monitoring generalized linear model (GLM) profil
In this paper we develop two models; the without shortages and the completely backlogging shortages with the price dependant demand rate under time value of money and inflation, finite time horizon and exponentially deterioration rate with the objective of maximizing the present worth of the total system profit. Using the dynamic programming method for each model, we are able to obtain different s
The present paper establishes a simulation framework for modelling the deposition and solidification of steel melt in Directed Energy Deposition with a Laser Beam (DED-LB) by using the Particle Finite Element Method (PFEM). Unlike traditional finite element methods, the remeshing framework makes it possible to resolve the interaction between molten metal and substrate upon deposition, solidificati
Aims: TCF7L2 rs7903146 is the most impactful single genetic risk variant for type 2 diabetes. However, its role on disease progression, complications and mortality among people with type 2 diabetes at diagnosis remains unclear. Materials and Methods: We assessed the per allele impact of the rs7903146 T-allele on clinical characteristics and complication risk in 9231 individuals with type 2 diabete
Understanding the “fit” of models designed to predict binary outcomes has been a longstanding problem across the social sciences. We propose a flexible, portable, and intuitive metric for quantifying the change in accuracy between two predictive systems in the case of a binary outcome: the InterModel Vigorish (IMV). The IMV is based on an analogy to weighted coins, well-characterized physical syst
Lean, premixed, swirl-stabilized flames are widely used in modern Dry Low Emissions gas turbine combustors; however, the turbulent combustion process under those conditions is known to be extremely sensitive and prone to instabilities. Numerical simulations can be a valuable tool in predicting the effects of alternative fuels; however, the sensitivity of the results to different models ought to be
