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Background: Presence of circulating tumor cells (CTCs) is a validated prognostic marker in metastatic breast cancer. Additional prognostic information may be obtained by morphologic characterization of CTCs. We explored whether apoptotic CTCs, CTC clusters and leukocytes attached to CTCs are associated with breast cancer subtype and prognosis at base-line (BL) and in follow-up (FU) blood samples i
A general, unstructured mathematical model has been used to describe the behaviour of nutrient-limited growth of two bacteria in a continuous co-culture. The experimental system consisted of a two-membered mixed culture of the heterotrophic nitrifier/aerobic denitrifier, Thiosphaera pantotropha, and the autotrophic nitrifier, Nitrosomonas europaea, competing for ammonia in chemostat culture. The o
Introduction Fever is an integral part of the inflammatory response and has therefore likely a physiological role in fighting infections. Nevertheless, whether fever in itself is beneficial or harmful in adults is unknown. This protocol for a systematic review aims at identifying the beneficial and harmful effects of fever control interventions in adults. Methods and analysis This protocol for a s
Purpose: To investigate the clinical management and outcome of patients with muscle-invasive bladder cancer with clinical lymph node involvement, using longitudinal nationwide population-based data. Methods: In the Bladder Cancer Data Base Sweden (BladderBaSe), treatment and survival in patients with urinary bladder cancer clinical stage T2–T4 N + M0 diagnosed between 1997 and 2014 was investigate
OBJECTIVE In type 2 diabetes, insulin resistance and progressive b-cell failure require treatment with high insulin doses, leading to weight gain. Our aim was to study whether a three-meal diet (3Mdiet) with a carbohydrate-rich breakfast may upregulate clock gene expression and, as a result, allow dose reduction of insulin, leading to weight loss and better glycemic control compared with an isocal
Evidence showed preventive impacts of the highly active antiretroviral therapy (HAART) on the Human Immunodeficiency Virus (HIV) transmission amomg heterosexual population, however, that is of deficit among men who have sex with men (MSM). The aim was to systematically examine the efficacy of HAART on HIV transmission and the association between the HAART initiation and unprotected anal intercours
We examine the causes and policy implications of strategic (willful) ignorance of risk as an excuse to over-engage in risky health behavior. In an experiment on Copenhagen adults, we allow subjects to choose whether to learn the calorie content of a meal before consuming it and then measure their subsequent calorie intake. Consistent with previous studies, we find strong evidence of strategic igno
Background: As part of I-O Optimise, a multinational research platform providing real-world insights into the management of lung cancers, the SCAN-LEAF study aims to describe the epidemiology, clinical care and outcomes for pts with NSCLC in Scandinavia. We report initial Tx and OS for pts with NSCLC prior to the availability of immunotherapies in Sweden. Methods: The analysis includes all adult p
High thyroid hormone values have been associated with an increased risk of incident cancers, especially breast cancer but also lung cancer and any solid cancers. We explored whether there is an increased risk of overall and cause-specific cancers in those receiving levothyroxine treatment. We included all individuals ≥ 18 years in Sweden (N = 8,573,313) on January 1 2009, and identified patients w
The cognitive components of subjective well-being can be measured with the Satisfaction with life scale (SWLS) and the Harmony in life scale (HILS), which both comprise five items each. The aim of this article is to abbreviate these scales and examine their psychometric properties and validity. Three datasets including test-retest data are used (N = 787; N = 860; N = 343). The two first datasets w
Economic growth has for a long time been the policy goal for Western cities. Since the decline of the Keynesian economic model, cities have to compete against others – on a global arena – to attract citizens and corporations to their cities. To reach the policy goal of economic growth cities develops growth oriented strategies. In a Swedish context, local politics have often been understood as the
All kinds of disputes arising from a commercial contract do not necessarily have to be brought before a court or an arbitral panel; market practice exhibits a great diversity of alternative ways of dispute resolution. This includes the inspection clause and the valuation clause, which are the dispute resolution methods scrutinized in this essay. Inspection clauses could for instance be found in co
Energipolitik har varit och är fortfarande av stor betydelse både för Medlemsstaterna och för EU. Behovet av att trygga en säker och pålitlig energiförsörjning är en central aspekt av en gemensam energipolitik. De senaste decennierna har det på EU-nivå pågått ett arbete att utveckla en enhetlig och samordnad strategi ämnad att trygga en säker elförsörjning inom EU. Några viktiga aspekter i EU:s stEnergy policy is a policy area of great significance for the Member States and for the EU. An integral part of every energy policy is the need to ensure a secure supply of electricity. At EU-level, the challenges to security of supply are to be managed via a coherent and coordinated approach aimed at taking into account the interest of the Union. Demand management, the further integration of the i
Background and aims: The primary aim of the present study was to examine whether there is an association between blood pressure and the risk of subsequent cognitive decline in the oldest old. Various factors associated with blood pressure and cognitive function were considered. Methods: The study comprised 599 individuals of a population-based sample, 199 men (mean age at baseline 82.8 years, rang
The goal of this research is to use hematopoietic cells as vehicles for targeting transgenic immunomodulators to the inflammatory sites. The work presented was focused on the anti-inflammatory soluble TNF receptor. A transmembrane soluble TNF receptor (sTNFR1) construct was expressed in hematopoietic cell lines. ER export was facilitated by addition of a transmembrane (tm) sequence, and constituti
We performed ultrasound measurements (QUS) of the calcaneus in a population-based setting on 280 healthy children, aged 11-16 years, from a small urban area in southern Sweden. The results are compared with dual-energy X-ray absorptiometry (DXA) measurements in the total body, the lumbar spine and the hip, as well as single-energy X-ray absorptiometry (SXA) of the forearm. Normative data and corre
Popular Abstract in Swedish The problem of fluid-structure interaction, occurring in many industrial and engineering applications, are of great importance, since interaction of a flow and a structure in it can lead to serious damages of the structure. The fluid-structure interaction gives rise to a variety of different physical phenomena such as flow-induced vibration, noise generation, etc. As anThe problem of fluid-structure interaction, occurring in many industrial and engineering applications, are of great importance, since interaction of a flow and a structure in it can lead to serious damages of the structure. The fluid-structure interaction gives rise to a variety of different physical phenomena such as flow-induced vibration, noise generation, etc. As an alternative to experimental
Sodium stearoyl-2 lactylate (SSL) lipid surfactant molecules specifically bind partially hydrolysed oat proteins in aqueous medium and significantly enhance the dispersion stability of oat cereal preparations. The proposed complexation is composition dependent and a greater understanding of the role of both oat proteins and lipid surfactant in the effect was gained with data from high performance
