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Objectives: Pain and disability are the main clinical manifestations of osteoarthritis, for which only symptomatic therapies are available. Hence, there is a need for therapies that can simultaneously alter disease progression and provide pain relief. KBP is a dual amylin- and calcitonin-receptor agonist with antiresorptive and chondroprotective properties. In this study we investigated the effect

A drone-based system for monitoring of laser-induced fluorescence from the aquatic environment was constructed. Fixed-range remote-sensing demonstration measurements were performed, and field recordings of natural river water fluorescence, oil-slicks as well as dye-marked natural water volumes were taken at drone flying heights of about 10 m. Our fluorosensor, weighing only 1.5 kg, and carried by

Background Whole-genome sequencing (WGS) of heart transplant recipient- and donor-derived cardiac biopsies may facilitate organ matching, graft failure prediction, and immunotolerance research. The objective of this study was to determine the feasibility of WGS based on formalin-fixed paraffin-embedded endomyocardial biopsies. Methods and results The study included serial donor- and recipient samp

Wolcott-Rallison syndrome is a rare genetic syndrome of neonatal diabetes, liver failure, and growth retardation. We present a case with a EIF2AK3 p.(Arg902Ter) mutation, additionally complicated by hypothyroidism, impaired renal function, and exocrine pancreas insufficiency, focusing on clinical management. For its optimization, thorough care of multiple organ systems is needed.

Background: Chronic pain is reported after 10–35 per cent of inguinal hernia operations. The aim was to compare quality of life (QoL) after total extraperitoneal (TEP) and Lichtenstein hernia repairs in the setting of an RCT with operations performed by department-certified hernia surgeons. Methods: Men aged 30–75 years with an ASA grade I–II primary inguinal hernia were randomized to TEP or Licht

The progesterone metabolite, allopregnanolone (AlloP), is a GABAA receptor modulating steroid and is known to have orexigenic and pro-obesity effects. The neurobiological mechanisms underpinning these effects are most likely due to enhanced GABAergic signaling in the lateral arcuate nucleus (ARC) and medial paraventricular nucleus (PVN) of the hypothalamus. Inspired by the finding that GABAergic s

A brief pedagogical introduction to correlation femtoscopy is given. We then focus on the shape of the correlation function and discuss the possible reasons for its departure from the Gaussian form and better reproduction with a Lévy stable distribution. With the help of Monte Carlo simulations based on asymmetric extension of the Blast-Wave model with resonances we demonstrate possible influence

Background: Patterns and determinants of long-term oral corticosteroid (OCS) use in asthma and related morbidity and mortality are not well-described. In a nationwide asthma cohort in Sweden, we evaluated the patterns and determinants of OCS use and risks of OCS-related morbidities and mortality. Methods: Data for 217 993 asthma patients (aged ≥ 6 years) in secondary care were identified between 2

We introduce new and simple algorithms for the calculation of the number of perfect matchings of complex weighted, undirected graphs with and without loops. Our compact formulas for the hafnian and loop hafnian of n × n complex matrices run in O(n32n/2) time, are embarrassingly parallelizable and, to the best of our knowledge, are the fastest exact algorithms to compute these quantities. Despite o

Recent studies in neurodegenerative conditions have increasingly highlighted that the same neuropathology can trigger different clinical phenotypes or, vice-versa, that similar phenotypes can be triggered by different neuropathologies. This evidence has called for the adoption of a pathology spectrum-based approach to study neurodegenerative proteinopathies. These conditions share brain deposition

In the ActivAbles and STARR projects we are developing interactive training tools for stroke survivors. Our initial user studies pointed to balance being a key ability, therefore one of the developed tools is an interactive balance pad. Equipment exists for persons with good balance (eg. Wii), but most consumer games and exercises are less suited for many stroke survivors. The development process

We enrolled 427 human immunodeficiency virus-infected children (median age, 7.3 years), 59.2% severely immunodeficient, with suspected tuberculosis in Southeast Asian and African settings. Nontuberculous mycobacteria were isolated in 46 children (10.8%); 45.7% of isolates were Mycobacterium avium complex. Southeast Asian origin, age 5-9 years, and severe immunodeficiency were independently associa

Measurement of forces exerted by a human hand while performing common gestures is a highly valuable task for assessment of neurorehabilitation and neurological disorders, but also, for control of movement that could be directly transferred to assistive devices. Even though accurate and selective multi-joint measurement of hand forces is desirable in both clinical and research applications there is

It is well established that thyroid hormones are required for cardiovascular functions; however, the molecular mechanisms remain incompletely understood, especially the individual contributions of genomic and non-genomic signalling pathways. In this study, we dissected how thyroid hormones modulate aortic contractility. To test the immediate effects of thyroid hormones on vasocontractility, we use

Pressure-driven membrane processes are often used for the separation and purification of organic compounds originating from biomass. However, membrane fouling remains a challenge as these bio-based streams have a very complex composition and comprise a high fouling tendency. Conventional, the fouling is monitored based on either a decrease in flux or an increase in pressure over time. Those conven

BACKGROUND/OBJECTIVES: Dementia and cognitive impairment are common in nursing homes. Few studies have studied the impact of unnoted cognitive impairment on medical care. This study aimed to estimate the prevalence of diagnostic failure of cognitive impairment in a sample of Swedish nursing home residents and to analyze whether diagnostic failure was associated with impaired medical care.METHOD: A

It is well recognized that the capacity of soils to sequester carbon (C) is strongly influenced by nitrogen (N) and phosphorus (P) availability because of the strong stoichiometric links between these biogeochemical cycles. Human disturbance (e.g., deposition, fertilization, and mining), has, and continue to have, caused large imbalances between the biogeochemical cycles and changing nutrient avai