An in vitro model was developed to characterize the electrical properties of silicon microfabricated recording electrodes, using a Cu-wire mimicing a neural signal source. Phosphorous doped electrodes were used to achieve an all silicon device. The model was used to study signal amplitude as a function of distance between the electrode surface and the signal source. Signal crosstalk to neighbourin

The use of motor reactions including spinal motor mechanisms, such as tail-flick, hot plate test, and flexion reflexes, in research on pain and analgesia requires some precautions, and results should be interpreted with caution. Nocifensive specificity and analgesic selectivity cannot be established unequivocally by only comparing reflexes evoked by noxious stimuli with monosynaptic reflexes. Rath

An antagonist to amino acid evoked excitation, γ-d-glutamylglycine (γ-DGG) inhibits, dose-dependently, nociceptive C-fibre evoked field potentials and neuronal discharges in single nociceptive neurons in rat spinal cord. It is concluded that amino acids are possible transmitter substance(s) in nociceptive afferent C-fibres. These results might be useful for development of centrally acting analgesi

In the halothane-anaesthetized rat, the responses of 49 neurons in the lumbo-sacral cord and the reflex discharge in the common peroneal nerve following electrical stimulation of the sural nerve were recorded in order to study possible relations between neuronal events and reflex nerve discharges. A distant noxious stimulus (to activate Diffuse Noxious Inhibitory Controls (DNIC) of Le Bars et al.1

Extracellular field potentials in the lumbosacral dorsal horn evoked by stimulation of cutaneous C fibres in the sural nerve were explored in the halothane‐anaesthetized rat. C‐fibre‐evoked field potentials were prominent in lamina II and lamina V of the dorsal horn. These potentials had a latency of 80‐130 ms and a duration of more than 200 ms. A peak in the C‐fibre‐evoked field potential, termed

Single unit electrical activity has been recorded from dorsal horn neurons in the lumbar spinal cord of adult rats which had been treated at birth with either capsaicin (50 mg kg-1) or with the solvent-vehicle only. The responses of these neurones to electrical stimulation of A- and C-fibres in the sural nerve and to natural stimulation of their cutaneous receptive fields have been studied. In veh

The responses of 56 neurons recorded in the lumbosacral spinal cord of halothane-anesthetized rats were studied following the application of mechanical stimuli to the skin on the lateral aspect of the paw or electrical stimulation of the sural nerve. Only neurons driven by A- and C-fiber stimulation were considered. The evoked activity in a nerve supplying flexor muscles, the common peroneal nerve

It is not clear where analgesic measures such as morphine and acupuncture have their sites of action. Since analgesia from acupuncturelike stimulation is reversed by naloxone (Sjolund and Eriksson, Brain Res. 173:295, 1979) it is probably mediated via endorphins. The two analgesic procedures mentioned may thus use similar inhibitory mechanisms. We now present data from autoradiographic measurement

Nociceptive C fiber input to SI in the halothane-nitrous oxide anesthetized rat was assessed by recording cortical field potentials evoked by noxious thermal cutaneous stimulation with CO2-laser pulses. Morphine topically applied onto the lumbar spinal cord produced a dose-dependent inhibition of nociceptive C fiber input from the hind paw to the contralateral SI. The inhibitory effect of morphine

Aim: It has been claimed that supraspinal structures are necessary forthe depression of nocifensive behaviour elicited by acupuncture or acupuncturelike (AL) stimulation. However, nocifensive reflexes in the spinal catwere inhibited for long periods by a mechanism releasing opieids on AL conditioning stimulation of groups II-III muscle afferents (Sj~lund and Eriksson, Neurosci.Lett. S3:264:1979).

Recent experimental studies suggest that the nociceptive withdrawal reflex system essentially has a "modular" organization, with each module concerned with the control of a single or a small group of muscles. This organizational principle appears to apply also to some spinoolivocerebellar pathways.

It is now well documented that the cerebellar cortex is divided into sagittal zones which can be identified by their climbing fibre inputs from specific regions of the inferior olive. Each cortical zone sends its efferent fibres, the Purkinje cell axons, to a separate group of neurones in the cerebellar or vestibular nuclei (Oscarsson, 1980, Voogd and Bigare, 1980, Voogd, 1982, Trott and Armstrong

Denna forskningsrapport sammanfattar resultaten från en studie bedriven inom ramen för Pilotverksamheten för bedömning av reell kompetens (REKO) under ledning av Universitets- och Högskolerådet (UHR). I studien utvecklas:• en generisk valideringsmodell för bedömning av reell kompetens för tillgodoräknande som högskoleutbildning. Valideringsmodellen (av både summativ och formativ karaktär) ska kunn