Changes in the location of γ-tubulin ensure cell survival and preserve genome integrity. We investigated whether the nuclear accumulation of γ-tubulin facilitates the transport of proliferating cell nuclear antigen (PCNA) between the cytosolic and the nuclear compartment in mammalian cells. We found that the γ-tubulin meshwork assists in the recruitment of PCNA to chromatin. Also, decreased levels

Bakgrund Den 20 januari 2020 senarelades ålderspensionen i Sverige för alla yrkesgrupper. Samtidigt ökar den arbetsrelaterade sjukligheten. I ett framtidsperspektiv kommer efterfrågan på arbetskraft som kan och vill arbeta till en högre ålder att öka utifrån den globala demografiska förändringen. Att medverka till en god anställningsbarhet (employability) och hälsa är därför en central fråga och uHållbart arbetsliv för alla åldrar – swAge modellenKerstin Nilsson1, 21Högskolan Kristianstad, 2Lunds universitetBakgrundDen 20 januari 2020 senarelades ålderspensionen i Sverige för alla yrkesgrupper. Samtidigtökar den arbetsrelaterade sjukligheten. I ett framtidsperspektiv kommer efterfrågan påarbetskraft som kan och vill arbeta till en högre ålder att öka utifrån den globala demografiskaförändr

Towards a theoretical model with an impact on a sustainable working life for all ages, the swAge – model (https://swage.org/en.html)

The continued expansion of plastics production all over the world entrenches modern societies and life styles deeper in the dependence on fossil resources. This research note develops the main aspects of the carbon lock-in in the plastics industry and how it extends into many aspects of contemporary life. With data collected from trade press and reports, we present insights of the investment trend

In recent years, gig work – short-term and temporary assignments mediated via digital platforms – has captured the interest of media and research and is growing as an area of academic inquiry. Previously research has mainly focused on the regulations and breadth of gig work. Gig work can be been understood as a significant break from ‘standard employment relationship’, meaning that we are now headIn recent years, gig work – short-term and temporary assignments mediated via digital platforms – has captured the interest of media and research and is growing as an area of academic inquiry. Previously research has mainly focused on the regulations and breadth of gig work. Gig work can be been understood as a significant break from ‘standard employment relationship’, meaning that we are now head

Hur kan vi skapa ett hållbart arbetsliv där individer mår bra, kan, vill och orkar befinna sig? Hur kan arbetsgivare, organisationer, företag ta till vara på det humankapital som individer utgör? Hur kan hälsa, inklusion, motivation, kunskap och kompetens värnas och utvecklas genom hela arbetslivet? I ett framtidsperspektiv kommer efterfrågan på arbetskraft som kan och vill arbeta till en högre ålHur kan vi skapa ett hållbart arbetsliv där individer mår bra, kan, vill och orkar befinna sig? Hur kan arbetsgivare, organisationer, företag ta till vara på det humankapital som individer utgör? Hur kan hälsa, inklusion, motivation, kunskap och kompetens värnas och utvecklas genom hela arbetslivet? I ett framtidsperspektiv kommer efterfrågan på arbetskraft som kan och vill arbeta till en högre ål

OBJECTIVES: Pain is a major symptom in patients with rheumatoid arthritis (RA). In early RA, pain is usually due to synovitis, but can also persist despite effective anti-inflammatory treatment. The objective of this study was to investigate the pain course over time and predictors of unacceptable pain and unacceptable pain with low inflammation, in patients with early RA.METHODS: An inception coh

Risk factors for ischemic stroke is suggested to differ by etiologic subtypes. The purpose of this study was to examine the associations between modifiable and non-modifiable risk factors and atherothrombotic stroke (i.e., excluding cardioembolic stroke), and to examine if the potential benefit of modifiable lifestyle factors differs among subjects with and without predisposing comorbidities. Afte

Mitochondrial homeostasis is essential for providing cellular energy, particularly in resource-demanding neurons, defects in which cause neurodegeneration, but the function of interferons (IFNs) in regulating neuronal mitochondrial homeostasis is unknown. We found that neuronal IFN-β is indispensable for mitochondrial homeostasis and metabolism, sustaining ATP levels and preventing excessive ROS b

Internal fixation failure in hip fractures can lead to reoperation. Calcium sulfate/hydroxyapatite (CaS/HA) is a biomaterial that can be used for augmenting fracture fixation. We aimed to determine whether an injection of 2 ml CaS/HA increases the fixation of a dynamic hip screw inserted in synthetic and human trabecular bone. The study consists of two parts: 1) synthetic bone blocks (n = 74), wit

Performance-based, service-life design of wood has been the focus of much research in recent decades. Previous works have been synthesized in various factorized design frameworks presented in the form of technical reports. Factorization does not consider the non-linear dependency between decay-influencing effects, such as between detail design and climate variables. The CLICKdesign project is a jo