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Small soluble oligomers, as well as dimers in particular, of the amyloid β-peptide (Aβ) are believed to play an important pathological role in Alzheimer's disease. Here, we investigate the spontaneous dimerization of Aβ42, with 42 residues, by implicit solvent all-atom Monte Carlo simulations, for the wild-type peptide and the mutants F20E, E22G and E22G/I31E. The observed dimers of these variants
This paper presents a summary of beam-induced backgrounds observed in the ATLAS detector and discusses methods to tag and remove background contaminated events in data. Trigger-rate based monitoring of beam-related backgrounds is presented. The correlations of backgrounds with machine conditions, such as residual pressure in the beam-pipe, are discussed. Results from dedicated beam-background simu
BACKGROUND: : Atherosclerosis is considered to be an inflammatory disease. Infections are a significant cause of inflammation. Acute infections might precipitate acute coronary syndromes (ACS) whereas chronic infections might be stimuli for the development of atherosclerosis. METHODS: : Coronary angiograms were done on 211 of 335 patients with ACS and the percentage of coronary obstruction was det
Heavy quarkonia are observed to be suppressed in relativistic heavy-ion collisions relative to their production in p + p collisions scaled by the number of binary collisions. In order to determine if this suppression is related to color screening of these states in the produced medium, one needs to account for other nuclear modifications including those in cold nuclear matter. In this paper, we pr
Critical functions of the immune system are maintained by the ability of myeloid progenitors to differentiate and mature into macrophages. We hypothesized that the cytoprotective gas molecule carbon monoxide (CO), generated endogenously by heme oxygenases (HO), promotes differentiation of progenitors into functional macrophages. Deletion of HO-1, specifically in the myeloid lineage (Lyz-Cre:Hmox1(
Correct diagnosis and staging are required for optimal treatment choice in lung cancer patients. This retrospective, patient medical records study investigated the clinical practice of lung cancer biopsy procedures and testing in Sweden.
The response of electric devices to an applied thermal gradient has, so far, been studied almost exclusively in two-terminal devices. Here we present measurements of the response to a thermal bias of a four-terminal, quasiballistic junction with a central scattering site. We find a novel transverse thermovoltage measured across isothermal contacts. Using a multiterminal scattering model extended t
Popular Abstract in Swedish Jordens totala energiförbrukning stiger. Samtidigt förbrukas primärt fossila naturresurser som kan anses ändliga, så som olja, kol eller naturgas, för att tillgodose energibehovet. Även andra energikällor används, t.ex. kärnbränsle, vind och vatten. Denna avhandling fokuserar på energi som omvandlas vid förbränning av gas i gasturbiner. Eftersom naturgas är ett fossilt In this thesis, the effect of alternative gaseous fuels, with high hydrogen content and lower calorific value, on gas turbine combustion was investigated experimentally. The aim of the investigation was to find operational limitations for an experimental burner and to supply data for validation of computational fluid dynamics (CFD). Before examination of the actual burner, the laminar flame speed
Nano-sized (10(-9)-10(-7) m) particles offer many technical and biomedical advances over the bulk material. The use of nanoparticles in cosmetics, detergents, food and other commercial products is rapidly increasing despite little knowledge of their effect on organism metabolism. We show here that commercially manufactured polystyrene nanoparticles, transported through an aquatic food chain from a
Using a simplified model for in-medium dipole evolution accounting for color filtering effects we study the production of hadrons at large transverse momenta p(T) in heavy ion collisions. In the framework of this model, several important sources of the nuclear suppression observed recently at RHIC and LHC have been analyzed. A short production length of the leading hadron l(p) causes a strong onse
Objectives The aim of this pilot study was to investigate cause(s) of heart failure (HF). Setting The emergency department and medical wards at Malmo University Hospital. Method A cross sectional pilot study. Main outcome measures Comparison of compliance, comprehension and optimal treatment on a population basis between men and women, younger (a parts per thousand currency sign75 years) and elder
The role of sulphur in the production of hydrogen in the small-scale for fuel cell applications is an important topic in the design of such systems and this review of the literature state-of-the-art has been performed to shed light on some of the possible trade-offs that will have to be done in designing these systems. The review-paper summarises the literature with respect to sulphur-laden cataly
Peritoneal dialysis involves diffusive and convective transports and osmosis through the highly vascularized peritoneal membrane. The capillary endothelium offers the rate-limiting hindrance for solute and water transport. It can be functionally described in terms of a three-pore model including transcellular, ultrasmall pores responsible for free-water transport during crystalloid osmosis. Severa
Due to the unavailability of culture-appropriate measurements of health-related quality of life (HRQOL) in China, knowledge about the HRQOL of women with cervical cancer, particularly in Mainland China, is poor. Such knowledge is greatly needed to inform nursing practice. Thus the main aim of this thesis was to investigate longitudinally the HRQOL trajectory in Chinese women from when cervical can
Increased snow depth already observed, and that predicted for the future are of critical importance to many geophysical and biological processes as well as human activities. The future characteristics of sub-arctic landscapes where permafrost is particularly vulnerable will depend on complex interactions between snow cover, vegetation and permafrost. An experimental manipulation was, therefore, se
