BACKGROUND: There is a growing body of evidence indicating the significant role of the immune system and immune cells in the progression of Alzheimer's disease (AD). However, the exact role of genes from various immune cell types in AD remains unclear. We aimed to utilize summary data-based Mendelian randomization (SMR) to explore the potential causal relationships between genes in specific immune

Clinical pathological diagnosis and prognosis for cancer is often confounded by spatial tissue heterogeneity. This study investigates the utility of entropy as a robust quantitative metric of spatial disorder within Fourier Transform Infrared (FTIR) chemical images of breast cancer tissue. The use of entropy is grounded in its capacity to encapsulate the complexities of pixel-wise spectral intensi

Improving the accuracy of estimated GFR (eGFR) measurement in kidney transplant recipients (KTRs) is an important goal.1 Current US and European recommendations suggest using race-free Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine-based eGFR (eGFRcr) equations (2021 age and sex [AS] or 2009 age, sex, and race–non-Black [ASR-NB]) in adults, without regard to cause or treatm

We report the discovery and characterization of a small planet, TOI-1408 c, on a 2.2 day orbit located interior to a previously known hot Jupiter, TOI-1408 b (P = 4.42 days, M = 1.86 ± 0.02 M Jup, R = 2.4 ± 0.5 R Jup) that exhibits grazing transits. The two planets are near 2:1 period commensurability, resulting in significant transit timing variations (TTVs) for both planets and transit duration

Decays of Ξb− and Ωb− baryons to Λc+h−h′− final states, with h−h′− being π−π−, K−π− and K−K− meson pairs, are searched for using data collected with the LHCb detector. The data sample studied corresponds to an integrated luminosity of 8.7 fb−1 of pp collisions collected at centre-of-mass energies s = 7, 8 and 13 TeV. The products of the relative branching fractions and fragmentation fractions for

This essay examines the Bavarian physician, mining engineer, and Catholic romantic philosopher Franz von Baader's (1765-1841) enigmatic claim that we think because we are thought with the help of the moral theologian Servain Pinckaers OP (1925-2008) and the psychologist Mihaly Csikszentmihalyi (1934-2021). Using Pinckaers' idea of 'fontal knowledge' and Csikszentmihalyi's notion of flow, I interprThis essay examines the Bavarian physician, mining engineer, and Catholic romantic philosopher Franz von Baader's (1765-1841) enigmatic claim that we think because we are thought with the help of the moral theologian Servain Pinckaers OP (1925-2008) and the psychologist Mihaly Csikszentmihalyi (1934-2021). Using Pinckaers' idea of 'fontal knowledge' and Csikszentmihalyi's notion of flow, I interpr

Measurements of the branching fraction ratio B(ϕ→μ+μ−)/B(ϕ→e+e−) with Ds +→π+ϕ and D+→ π+ϕ decays, denoted Rϕπ s and Rϕπ d, are presented. The analysis is performed using a dataset corresponding to an integrated luminosity of 5.4 fb−1 of pp collision data collected with the LHCb experiment. The branching fractions are normalised with respect to the B+ → K+J/ψ(→ e+e−) and B+ → K+J/ψ(→ μ+μ−) decay m

In this text, I develop my earlier argument on the possibility of a non-confessional theological inquiry, and hence an intellectual practice devoted to the classical theological problems that begin with reason rather than faith, at secular universities in Sweden, a country with no state church and many different religions and denominations. I answer the criticism against this tentative proposal by

The four decays, Λb0→ςc(∗)++D(∗)-K-, are observed for the first time using proton-proton collision data collected with the LHCb detector at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 6 fb-1. By considering the Λb0→Λc+D¯0K- decay as reference channel, the following branching fraction ratios are measured to be B(Λb0→ςc++D-K-)B(Λb0→Λc+D¯0K-)=0.282±0.016±0.016±0.00

Following the claim in Fides et Ratio that »[m]etaphysics … plays an essential role of meditation in theological research« (John Paul II 1998), I examine how the neuroscientists Christof Koch and Giulio Tononi's Integrated Information Theory (IIT) challenges a physicalist view on consciousness and even life. I discuss IIT in relation to the mathematician Norbert Wiener's Augustinian view on the orFollowing the claim in Fides et Ratio that »[m]etaphysics … plays an essential role of meditation in theological research« (John Paul II 1998), I examine how the neuroscientists Christof Koch and Giulio Tononi's Integrated Information Theory (IIT) challenges a physicalist view on consciousness and even life. I discuss IIT in relation to the mathematician Norbert Wiener's Augustinian view on the or

This article examines the emergence of idealism in evolutionary cognitive science by analyzing the conscious realism of the cognitive theorist Donald D. Hoffman and the mathematician Chetan Prakash. Perception is for them not about veridical experience, but rather a mechanism for survival. It helps us survive but does not give us access to reality as such. By relating Hoffman and Prakash's conscio

Absract in Italian:Alla fine di uno dei saggi contenuti in Con le spalle al futuro, Tronti si domanda: «Dobbiamo assumere noi, come filosofia dell’avvenire, il progetto di una riteologizzazione dei concetti secolarizzati?»¹.Qui intendo aprire un confronto con la riflessione sviluppata da Tronti sulla teologia, e in particolare su ciò che definisce la “differenza umana”, per evidenziare quanto ciò