Invasive infections remains one of the leading causes of death due to infections over the world, and efficient treatment remains elusive. One of the major causes of sepsis and other invasive infections is pathogenic streptococci that cause a wide range of clinical manifestations in humans. Group A and group G streptococci have both been shown to cause both infections of milder ranges as well as se

The functional significance of fibrin deposits typically seen in inflammatory lesions, carcinomas and in healing wounds is not fully understood. In the present study, we demonstrate that fibrinogen/fibrin specifically bound to native Col I (collagen type I) and used the Col I fibre network as a base to provide a functional interface matrix that connects cells to the Col I fibres through alpha V be

We present a novel design for a macrostructured cathode that can be coated with a thin layer of the B-10 solid converter and mounted to replace the Boron-lined flat parallel plates of a proportional counter used for slow neutron detection. The proposed design consists of a 3D regular pattern exhibiting millimeter deep grooves with an opening angle of alpha = 45 degrees, which could be created in t

Thin films of (B4C)-B-10 have shown to be very suitable as neutron-converting material in the next generation of neutron detectors, replacing the previous predominantly used He-3. In this contribution we show under realistic conditions that (B4C)-B-10 films are not damaged by the neutron irradiation and interactions, which they will be exposed to under many years in a neutron detector. 1 mu m thic

This column examines the texture cache, an essential component of modern GPUs that plays an important role in achieving real-time performance when generating realistic images. GPUs have many components and the texture cache is only one of them. But it has a real impact on the performance of the GPU if rasterization and memory tiling are set up correctly.

The solvolysis of substituted benzoyl chlorides is sensitive both to substituent electronic effects and to medium effects. The solvolysis reactions of substituted benzoyl chlorides have been analyzed in the presence of nonionic micelles. The reaction is inhibited or catalyzed depending on the reaction mechanism, dissociative or associative, respectively. The micellar effects observed can be relate

Popular Abstract in Swedish Varje år drabbas i världen ca 3 miljoner individer av cancer i mag-tarmkanalen. Stora skillnader finns i incidens med magsäckscancer och matstrupscancer särskilt vanliga i utvecklingsländer, medan tjock- och ändtarmscancer är en av de vanligaste tumörtyperna i västvärlden. Cancer i mag-tarmkanalen ger ofta diffusa symtom, vilket i många fall leder till att tumörerna uppEsophageal cancer and colorectal cancer represents two major types of gastrointestinal tumors. Though refined surgery and introduction of novel chemotherapeutics have improved outcome, more than 2500 Swedes die from these diseases every year. Novel markers for early diagnosis, prognosis and treatment prediction are therefore needed. This thesis aimed to genetically profile esophageal cancer with c

By using a Swern oxidation-epimerization-reduction sequence it is possible to selectively epimerize any position in isopropylidene-protected xylopyranosides, thus forming arabinosides, ribosides, and lyxosides. The driving force for epimerization of position 3 (xylo to ribo) is the release of ring strain by going from a 1,2-trans-acetal to a 1,2-cis-acetal.

Background: Sarcoidosis patients show dysregulated immune function, which may be related to subsequent cancer. We examined here the overall and specific cancer risks among Swedish subjects who had been hospitalized for sarcoidosis. Methods: A sarcoidosis research database was created by identifying hospitalized sarcoidosis patients from the Swedish Hospital Discharge Register and by linking them w

Den japanska byggsektorn är ofta ett föredöme för vår egen industris omvandling, t.ex. inom industrialisering och lean. Även när det gäller tillämpning och utveckling av Informations- och Kommunikations- Teknologi, ICT, t.ex. för BIM, ByggnadsInformationsModellering, har man mångårig avancerad erfarenhet som är intressant för oss att ta del av. Samtidig visar det sig att användningen och erfarenhe

Multiple exciton generation (MEG) is a process in which more than one exciton is generated upon the absorption of a high energy photon, typically higher than two times the band gap, in semiconductor nanocrystals. It can be observed experimentally using time resolved spectroscopy such as the transient absorption measurements. Quantification of the MEG yield is usually done by assuming that the bi-e

Developmental pluripotency-associated 5 (Dppa5) is an RNA binding protein highly expressed in undifferentiated pluripotent stem cells. Here, we demonstrate that Dppa5 is a regulator of hematopoietic stem cells (HSCs) that critically governs reconstitution capacity after bone marrow transplantation. Ectopic expression of Dppa5 followed by in vitro culture robustly increased HSC reconstitution level

Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by production of autoantibodies and complex genetic inheritance(1-3). In a genome-wide scan using 85,042 SNPs, we identified an association between SLE and a nonsynonymous substitution (rs10516487, R61H) in the B-cell scaffold protein with ankyrin repeats gene, BANK1. We replicated the association in four indepen

The metabolic syndrome is a clustering of several risk factors associated with diabetes and cardiovascular disease. Diabetes is a global problem with 90% of patients suffering from type 2 diabetes (T2D), which is attributable to various factors including genetic predispositions and lifestyle. In T2D, there is a reduction in β cell mass and function, and impaired glucose homeostasis. It is often as

Many studies have shown that female managers have to work harder than men to gain recognition, and that this often leads top female managers away from the leadership style characterized by soft skills and emotional understanding. Instead, another characterization can be seen; that of tough gendered machines fighting their way to the top - cyborgs. This article uses Haraway's metaphor of the cyborg

Popular Abstract in Swedish Huntingtons sjukdom (HS) är en ärftlig och dödlig sjukdom som karakteriseras av ofrivilliga, danslika rörelser vilket gjort att den i folkmun kallas för danssjuka. Diagnosen ställs när de motoriska problemen (ofrivilliga rörelserna) uppträder, vanligtvis i medelåldern, och dessa ökar sedan gradvis och den drabbade personen avlider på grund av sjukdomen efter cirka 15-25Non-motor symptoms and signs such as metabolic and psychiatric disturbances have been reported to occur early in Huntington’s disease (HD), a fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. However, there is a lack of understanding of the underlying neurobiological mechanisms responsible for the early non-motor features. The hypothalamus has emerged as an

Most fractures heal uneventfully but some evolve into nonunions. Autologous bone graft is the gold standard for stimulating healing. However, donor site morbidity, and limited graft supply make alternatives interesting. Bone Morphogenetic Proteins, BMPs, are growth factors involved in bone signaling. They are available in recombinant form for local application in nonunions and stimulate differenti