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The overall purpose of this thesis was to reduce brain tissue responses around implanted microelectrodes using a pharmacological strategy. One of the main aims was to develop and evaluate drug delivery systems that allow local administration of anti-inflammatory pharmaceutics. The drug Minocycline was therefore encapsulated into biodegradable poly (D,L-lactic-co-glycolic acid) nanoparticles and th

Canesin et al. describe a role and mechanism for labile heme as a key player in regulating gene expression to promote carcinogenesis via binding to G-quadruplex in the c-MYC promoter. Hemopexin, a heme scavenger, may be used as a strategy to block progression of cancer.

OBJECTIVE: To determine whether atrophy relates to phenotypical variants of posterior cortical atrophy (PCA) recently proposed in clinical criteria (i.e., dorsal, ventral, dominant-parietal, and caudal) we assessed associations between latent atrophy factors and cognition. METHODS: We employed a data-driven Bayesian modeling framework based on latent Dirichlet allocation to identify latent atrophy

Background: Every year, many infants are infected with the respiratory syncytial virus (RSV) or other agents and need hospitalisation due to bronchiolitis. The disease causes much suffering and high costs. Thus, it is important that the treatment methods are both effective and cost-efficient. The use of different physiotherapy treatment methods is debated, and not all methods are evaluated scienti

The photo-electro catalysis has emerged as efficient and sustainable degradation method for antibiotics, where metal oxide anode plays a critical role. Exploring novel preparation method for anodes catalysis to achieve larger active sites and diverse oxidants production can directly enhance the degradation performance. Therefore, in this work, a new urea precipitation method for anode formation wa

The invasive yellow-fever mosquito Aedes aegypti preferentially feeds on human blood. A new study finds that human-biting in this important disease vector might just be an unfortunate side effect of breeding in human-stored water.

Cellulose can be dissolved in concentrated acidic aqueous solvents forming extremely viscous solutions, and, in some cases, liquid crystalline phases. In this work, the concentrated phosphoric acid aqueous solvent is revisited implementing a set of advanced techniques, such as cryo-transmission electronic microscopy (cryo-TEM), polarization transfer solid-state nuclear magnetic resonance (PTssNMR)

The new luminescent carbonyl compounds [Mn(Oxa-H)(CO)3Br] (1) and [Mn(Oxa-NMe2)(CO)3Br] (2) were synthesized and fully characterized. Complexes 1 and 2 showed CO release under blue light (λ453). Spectroscopic techniques and TD-DFT and SOC-TD-DFT calculations indicated that 1 and 2 release the Oxa-H and Oxa-NMe2 coligands in addition to the carbonyl ligands, increasing the luminescence during photo

Lack of methods to experimentally assess the perceptual processing of sound features and allow one to measure differences in phonological proficiency has been a limitation for speech processing studies in native speakers. Tonal features associated with Swedish word-stems, word accents, which cue grammatical suffixes, constitute, however, such sound features that can be exploited to generate measur

Ammonium-nitrogen (NH4+) nutrition is linked to metabolic over-reduction for plants. The characteristic symptom of sole NH4+ nutrition is growth suppression, signifying this condition as the ammonium syndrome. In the present study, we investigated the mechanism of perception of high NH4+ conditions in Arabidopsis thaliana plants by examining apoplastic reactive oxygen species (ROS) metabolism. Maj

The last three decades have seen an increase of tests aimed at measuring an individual’s vocabulary level or size. The target words used in these tests are typically sampled from word frequency lists, which are in turn based on language corpora. Conventionally, test developers sample items from frequency bands of 1000 words; different tests employ different sampling ratios. Some have as few as 5 o

Background: Since 2015 operations performed in the field of endocrine surgery have been entered into the European registry EUROCRINE®. The aim of this analysis was a description of the current healthcare situation for adrenal surgery in a homogeneous healthcare environment corresponding to the German-speaking countries—or to the presence of the working group on surgical endocrinology (CAEK) of the

En artikel som behandlar forskningsprojektet "Bygga och utveckla plats genom mänskliga minnen".

Forskningsprojektet Equalizer 2.0 syftade till att förändra skolgårdar utifrån ett inkluderande och normkritiskt perspektiv, detta för att skapa större möjlighet till fysisk aktivitet och rörlighet hos unga människor. Dessa invigdes det angivna datumet på Fäladsgårdens skola och Östratornskolan i Lund.

Primary tumours of bone are heterogenous and infrequent neoplasms. Distinguishing between benign, intermediate and malignant entities can in some instances pose a clinical challenge. For some tumour types, there is still much to be learned about the genetic mechanisms that give rise to and drive these tumours forward. With the hope of improving diagnostic accuracy and treatment outcomes on the lon

In this presentation, I will discuss how the role of instruments in musical practice can be under- stood, through a theoretical framework drawing upon the emerging paradigm of 4E cognition. Ani- mating the discussion are two studies, an interview study and a co-operative inquiry, together forming the empirical basis of my PhD-project. The case here is the simple-system flute, an in- strument that

The variance in phenotypic trait values is a product of environmental and genetic variation. The sensitivity of traits to environmental variation has a genetic component and is likely to be under selection. However, there are few studies investigating the evolution of this sensitivity, in part due to the challenges of estimating the environmental variance. The livestock literature provides a wealt

Given 1 ≤ q< p< ∞, quantitative weighted Lp estimates, in terms of Aq weights, for vector-valued maximal functions, Calderón–Zygmund operators, commutators, and maximal rough singular integrals are obtained. The results for singular operators will rely upon suitable convex body domination results, which in the case of commutators will be provided in this work, obtaining as a byproduct a new proof

Dispersal ability is key to species persistence in times of environmental change. Assessing a species' vulnerability and response to anthropogenic changes is often performed using one of two methods: correlative approaches that infer dispersal potential based on traits, such as wingspan or an index of mobility derived from expert opinion, or a mechanistic modeling approach that extrapolates displa