Background: Parkinson's disease (PD) diagnosis is mainly based on clinical criteria, with a high risk of misdiagnosis. The identification of reliable biomarkers for disease diagnosis and progression has a key role for developing disease-modifying therapies. In this article, we investigated the longitudinal changes of CSF α-synuclein species in early PD patients and explored the potential use of th

Cognitively-normal people with evidence of β-amyloid (Aβ) pathology and subtle cognitive dysfunction are believed to be at high risk for progression to mild cognitive impairment due to Alzheimer's disease (AD). Clinical trials in later stages of AD typically include a coprimary endpoint to demonstrate efficacy on both cognitive and functional assessments. Recent trials focus on cognitively-normal

The aim of this study was to further investigate the psychometric properties (with focus on construct validity and scale function) of the Swedish version of the Person-centred Care Assessment Tool (P-CAT) in a sample consisting of staff working in elderly care units (N = 142). The aim was also to further develop and psychometrically test a modified, noncontext-specific version of the instrument (m

This study analyses psychological an tecedents of feelings of fear of wolves in a proportional sample of the Swedish population ( national sample, n = 545) andin a sample of people in c ounties with wolf presence (regi onal sample, n = 1,892). Structural equation model-ling of survey data suggests a dual pathway to self-re porte d fear. One path encompa sses the appraisal of the environmental cont

Det är inte alla teknologer som antas till en civilingenjörsutbildning som verkligen tar examen. Vid LTH har, till exempel, bara var tionde teknolog tagit examen inom den nominella tiden 4.5 år. Inte förrän efter 6 år har hälften tagit examen och efter 15 år är det fortfarande en tredjedel av dem som en gång antogs som saknar examen. Inspirationen till denna studie var behovet att försöka hitta nåDet är inte alla teknologer som antas till en civilingenjörsutbildning som verkligen tar examen. Vid LTH har, till exempel, bara var tionde teknolog tagit examen inom den nominella tiden 4.5 år. Inte förrän efter 6 år har hälften tagit examen och efter 15 år är det fortfarande en tredjedel av dem som en gång antogs som saknar examen. Inspirationen till denna studie var behovet att försöka hitta nå

The discovery of lithium-rich giants contradicts expectations from canonical stellar evolution. Here we report on the serendipitous discovery of 20 Li-rich giants observed during the Gaia-ESO Survey, which includes the first nine Li-rich giant stars known towards the CoRoT fields. Most of our Li-rich giants have near-solar metallicities and stellar parameters consistent with being before the lumin

The day Faraday moved a magnet in and out of a wire loop and detected the time-varying magnetic field, the first wireless transmitter / receiver system was created and the world was changed forever. However, it took almost fifty years for Heinrich Hertz to use Maxwell's equations and Faraday's insights in his professorship at Karlsruhe to create the first electromagnetic wireless communication sys

Endothelial cells release ATP in response to fluid shear stress, which activates purinergic (P2) receptor-mediated signaling molecules including endothelial nitric oxide (eNOS), a regulator of vascular tone. While P2 receptor-mediated signaling in the vasculature is well studied, the role of P2Y2 receptors in shear stress-associated endothelial cell alignment, cytoskeletal alterations, and wound r

The present study investigates the influence of seagrass root systems on benthic hard-shelled meiofauna (foraminifera). In February and July 2011, sediment cores were collected at low tide at two sites in Arcachon lagoon, a vegetated site with Zostera noltei and a second site with bare sediments. We used the highly discriminative CellTracker™ Green fluorogenic probe technique to recognize living f

We report growth and characterization of a coupled quantum dot structure that utilizes nanowire templates for selective epitaxy of radial heterostructures. The starting point is a zinc blende InAs nanowire with thin segments of wurtzite structure. These segments have dual roles: they act as tunnel barriers for electron transport in the InAs core, and they also locally suppress growth of a GaSb she

Climate change could pose a major challenge to efforts towards strongly increase food production over the coming decades. However, model simulations of future climate-impacts on crop yields differ substantially in the magnitude and even direction of the projected change. Combining observations of current maximum-attainable yield with climate analogues, we provide a complementary method of assessin

Colloidal dispersions have attracted much attention both from academia and industry due to industrial significance and complex dynamic properties. Accordingly, a variety of attempts have been made to understand the complicated physics of colloidal dispersions. Particle dynamics simulation has been playing an important role in exploring colloidal systems as a strong complement to experimental appro

Within the realm of furniture is the copy a controversial subject matter and is often discussed in terms of “real or fake”, “copy or original”. Walter Benjamin was probably the first theorist to pay attention to the power of the copy, in terms of changing our social and cultural attitudes towards the nature of representation with his Das Kunstwerk im Zeitalter seiner technischen Reproduzierbarkeit

Naumovozyma castellii (Saccharomyces castellii) is a member of the budding yeast family Saccharomycetaceae. It has been extensively used as a model organism for telomere biology research and has gained an increasing interest as a budding yeast model for functional analyses owing to its amenability to genetic modifications. Due to the suitable phylogenetic distance to S. cerevisiae the whole genome