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This paper is the third in a series which recounts experiences in a project conducted in a newly-created Department of the University of Portsmouth (see also Bednar et al, 2004 and Eglin et al, 2005). A variant of the Strategic Systemic Thinking (SST) Framework (Bednar, 2000) was used to support the 25 staff of the Department to explore possibilities for development in a range of areas of work rel

To test for chaotic dynamics of the insulin producing beta-cell and explore its biological role, we observed the action potentials with the perforated patch clamp technique, for isolated cells as well as for intact cells of the mouse pancreatic islet. The time series obtained were analyzed using nonlinear diagnostic algorithms associated with the surrogate method. The isolated cells exhibited shor

The electromagnetic (EM) energy flow near single spheres is investigated by applying Mie theory. From the patterns of the energy flow, the absorption and the scattering of light can be understood in the microscopic point of view. In the absorption profiles of metallic particles, most absorbed energy is consumed on the surface of the particles, which indicates that the resonance of surface plasmon

Postmenopausal overweight women have an increased risk of breast cancer. The link between obesity and breast cancer could be mediated through hyperinsulinemia. Insulin and insulin-like growth factor-1 (IGF-1) stimulate mammary cell proliferation in vitro, and cell proliferation is directly linked to the risk of breast cancer. Our objective was to investigate the relationship between breast cancer

The aim of the TEDDY study is to identify infectious agents, dietary factors, or other environmental agents, including psychosocial factors, which may either trigger islet autoimmunity, type 1 diabetes mellitus (T1DM), or both. The study has two end points: (a) appearance of islet autoantibodies and (b) clinical diagnosis of T1DM. Six clinical centers screen newborns for high-risk HLA genotypes. A

An appreciable percentage of patients with serum anti-glomerular basement membrane (anti-GBM) antibodies also have antineutrophil cytoplasmic antibodies (ANCA), against either myeloperoxidase (MPO-ANCA), or proteinase 3 (PR3-ANCA). In sera without ANCA, the anti-GBM antibodies have been shown to react mainly with the noncollagenous domain (NC1) of Type IV collagen, and especially with its alpha 3

2D and 3D models of a superconducting undulator suitable for the ESRF storage ring have been developed. The models are based on the performance of superconducting NbTi wire available from the cabling industry. Iron is used in the poles to enhance the peak field. The 2D model shows that it is possible to obtain a peak field of 1.18 T, corresponding to a K-value of 1.65, for a period length of 15 mm

Popular Abstract in Swedish Förebyggande miljöskyddslösningar har under flera år tillämpats med stor framgång i den tillverkande industrin. Den har dock används i mycket i liten omfattning i service sektorn. I takt med att tjänstesektorns ekonomiska betydelse ökat, har även miljöaspekten av ett ökat tjänsteutbud kommit i fokus. Denna avhandling förklarar hur förebyggande miljöskydd som ett strategPreventative environmental approaches (e.g. Cleaner Production and Pollution Prevention) have been successfully implemented in the manufacturing industry. They are, however, far from being fully adopted by all society actors. It has, for instance, not been fully embraced by the service sector. When this research project started, the initial question was whether it was possible to adopt experiences

High-resolution, non-invasive, 3D-imaging techniques would greatly benefit the investigation of the localization properties of tumor-specific radiopharmaceuticals in laboratory animals. The present study reports how pinhole SPECT can be applied to tumor localization studies in small laboratory animals to provide high resolution SPECT images in vivo. Pinhole SPECT was performed using a rotating sci

The somatic cell count (SCC) in bovine milk is an indicator of udder health and milk quality. Individual cell populations, i.e., macrophages, lymphocytes and polymorphonuclear neutrophils, were identified and their relationship to milk components such as acute-phase proteins (serum amyloid A (SAA) and alpha(1)-acid glycoprotein), lactic acid and lactoferrin (LF), as well as protein, fat and lactos

Beim Fahrradfahren arbeitet der Mensch als Regler. Das wird beim Balancieren des Fahrrades besonders offensichtlich, denn das Fahrrad ist instabil. In diesem Beitrag wird untersucht, unter welchen Bedingungen es möglich ist, das Fahrrad mit einem so einfachen Reglergesetz zu balancieren, dass Menschen dieses Reglergesetz ohne Mühe realisieren können. Dabei wird nicht nur die jedem Radfahrer bekann

Low body mass index (BMI) is a well-documented risk factor for future fracture. The aim of this study was to quantify this effect and to explore the association of BMI with fracture risk in relation to age, gender and bone mineral density (BMD) from an international perspective using worldwide data. We studied individual participant data from almost 60,000 men and women from 12 prospective populat