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Objectives: To evaluate costs, benefits, and cost effectiveness of tumour necrosis factor inhibitor treatment over one year in routine clinical practice. Materials and methods: At four rheumatology units in southern Sweden treatment of 160 consecutive patients with RA was started with either etanercept or infliximab. The economic analysis was based on 116 patients with complete data who received
RATIONALE AND OBJECTIVES: The authors evaluated the coordination of swallowing and respiration in dysphagic patients. MATERIALS AND METHODS: Video fluoroscopy and respirometry were performed simultaneously during 98 swallows in 33 patients (18 women, 15 men) with a median age of 70 years (interquartile range, 52-78 years). Pharyngeal transit time, deglutition apnea, and the ratio between the two (
Objective: We reviewed the literature on nodal staging in patients with bladder cancer treated with radical cystectomy and lymphadenectomy. Results: Fractionating the lymph node specimen significantly increases the node count, whereas results are contradictory as to whether that increase improves detection of positive nodes. Pathoanatomic data indicate that extending lymph node dissection to the a
In order to evaluate the potential of cardiovascular tissue characterisation using near-infrared (NIR) spectroscopy, spectra in a previously unexplored wavelength region 0.8-2.3 mu m were recorded from various pig heart tissue samples in vitro: normal myocardium (with and without endo/epicardium), aorta; fatty and fibrous heart tissue. The spectra were analysed with principal component analysis (P
The molecular changes underlying neural progenitor differentiation are essentially unknown. We applied cDNA microarrays with 13,627 clones to measure dynamic gene expression changes during the in vitro differentiation of neural progenitor cells that were isolated from the subventricular zone of postnatal day 7 mice and grown in vitro as neurospheres. In two experimental series in which we withdrew
The temporal contrast is classified into two main regimes, the nanosecond-scale and the picosecond-scale contrast prior to the main pulse. The Lund terawatt laser system is shown to be improved on the nano- and picosecond-scale by a factor of 10 and 50, respectively, when it was optimized for contrast but not for energy. Calculations are also presented to emphasize the role of angular dispersion o
Excited-state lifetimes for a number of vibronic states of (1)Pi(u) symmetry in molecular nitrogen have been determined experimentally in a laser-based pump-probe scheme using a coherent and tunable extreme ultraviolet source based on harmonic generation. States investigated in N-14(2) were b(1)Pi(u)(v = 6-9), of valence character, and c(3)(1)Pi(u)(v = 1) and o(3)(1)Pi(u)(v = 1), of Rydberg charac
A common problem during recovery of bioproducts by adsorption from particulate broths is fouling of the adsorbent material as a result of the interaction of cells and cell debris, which present negative charges, with the positively charged anion exchangers commonly used in bioprocesses. The effect of shielding an adsorbent with a layer of agarose on reducing the binding of cells while still allowi
Parkinson’s disease is one of the most common neurodegenerative diseases, and affects approximately 1% of the population over 65 years of age. Many different insults appear to be involved in the etiology of the disease, among them environmental toxins and mitochondrial dysfunction. During the past five years, mutations in five different genes have been linked to rare, familial forms of Parkinson’s
The optical properties of pig heart tissue were measured after in vivo ablation therapy had been performed during open-heart surgery. In vitro samples of normal and ablated tissue were subjected to measurements with an optically integrating sphere set-up in the region 470-900nm. Three independent measurements were made: total transmittance, total reflectance and collimated transmittance, which mad
When evaluating drug substances, the traditional clinical study setting does not allow scope for observing real-life behaviour since all alternative actions are determined beforehand. However, a study based on prospective or retrospective databases containing real-life data can examine how patients and physicians behave in a real-world setting and can investigate the relationship between the intro
The synthesis of the Linear B type 2 trisaccharide (Galalpha3Galbeta4GlcNAc-betaOTMSEt) and the corresponding 2-carboxyethyl beta-thioglycoside is described, as well as coupling of the latter to Sepharose.
Question: Under what circumstances does a capacity for multi-stage dormancy (i.e. dormancy in more than one life-stage) evolve? Mathematical methods: Optimization in stochastic environments. Results are derived both analytically and by simulations. Key assumption: There exists some trade-off between resources allocated to reproduction and adult dormant survival. Different shapes of this trade-off
Abstract in Undetermined Debattinlägg om akademisk frihet inom ramen för serie med gästkrönikörer.
Frequent loss of heterozygosity in head and neck squamous cell carcinoma (HNSCC) has been found in several chromosomal regions such as 3p, 9p, 11q, 13q and 17p. Fragile histidine triad (FHIT) gene is located at 3p14.2 encompassing a common fragile site, and is identified as a tumor suppressor gene. We examined 57 patients with HNSCC using immunohistochemistry, western blot, and reverse transcripta
