The three-dimensional structure of Bruton's agammaloglobulinemia tyrosine kinase (Btk) SH2 domain was modeled based on v-Src. Btk SH2 is presumably very related to the other SH2 structures consisting of two beta-sheets surrounded by two alpha-helices, with a well conserved hydrophobic core and phoshotyrosyl peptide binding site. The model was used to predict the recognition sequence of the target

The beta-cell loss seen in diabetes mellitus could be monitored clinically by positron emission tomography (PET) if imaging agents were sufficiently specific for beta-cells to overcome the high ratio of non-beta-cell to beta-cell tissue in pancreas. In this report, we present a screening assay for identifying beta-cell-specific compounds that is based on the relative accumulation and retention by

Low-temperature absorption and fluorescence spectra of fully active cores and membrane-bound PS II preparations are compared. Detailed temperature dependence of fluorescence spectra between 5 and 70 K are presented as well as 1.7-K fluorescence line-narrowed (FLN) spectra of cores, confirming that PS II emission is composite. Spectra are compared to those reported for LHCII, CP43, CP47 and D1/D2/c

Analyses regional differences across China, employing an optimum currency area framework.

Ribosome recycling factor (RRF), together with elongation factor G (EF-G), catalyzes recycling of ribosomes after one round of protein synthesis. The crystal structure of RRF was determined at 2.55 angstrom resolution. The protein has an unusual fold where domain I is a long three-helix bundle and domain II is a three-layer β/α/β sandwich. The molecule superimposes almost perfectly with a transfer

Popular Abstract in Swedish Denna avhandling presenterar en teori om hur utforskande och hantering av verktyg kan få människor att överskrida förutfattade begränsningar. Personer med grava kognitiva funktionshinder har mycket svåra begränsningar i sina förutsättningar att delta i aktiviteter som kan skapa mål och mening och bidra till förändringar i deras liv. De har svårartade inskränkningar närThe Driving to Learn project explored possible achievements of training people with cognitive disabilities in a joystick-operated powered wheelchair utilizing the grounded theory approach. Theoretical sampling led the concomitant collection and analysis of data. During a period of 12 years, 45 participants with profound cognitive disabilities, aged 12 months to 52 years, were engaged in the projec

The role of biomass burning aerosols in the climate system is still poorly quantified, in part due to uncertainties regarding the optical properties of elemental and organic carbon (EC and OC, respectively), the main constituents of pyrogenic aerosols. In this study, we utilize comprehensive physical and chemical field measurements of biomass burning aerosols in Brazil to constrain the densities a

Abstract in UndeterminedCash-Flow-at-Risk (CFaR) is the cash flow equivalent of Value-at-Risk (VaR), a measure widely used as the basis for risk management in financial institutions. Whereas VaR-based systems specify the maximum amount of total value a firm is expected to lose under most foreseeable conditions (for example, with a 99% confidence level), CFaR-based systems determine the maximum sho

In this study, we describe the expression and function of CD40, a TNF receptor family member, in cervical carcinomas. CD40 was present at very low levels in normal cervical epithelium but was overexpressed in human papillomavirus-infected lesions and advanced squamous carcinomas of the cervix. The stimulation of CD40-positive cervical carcinoma cell lines with soluble CD40L (CD154) resulted in act

This thesis presents experimental investigations of local heat transfer and detailed flow measurements in ribbed rectangular ducts and impinging jets. The advanced measurement methods, Liquid Crystal Thermography (LCT) and Particle Image Velocimetry (PIV) are adopted to provide full field characteristics. The work consists of two parts, regarding rib-roughened rectangular ducts and impinging slot

No surveillance is recommended after radical excision of low-risk adenomas (pedunculated adenoma irrespective of size, sessile adenoma < or = 10 mm, number < or = 2. An endoscopic check-up is recommended 3-6 months after radical excision of high-risk adenomas (sessile adenoma > 10 mm, number > or = 3), as well as after excision of a pedunculated or a sessile adenoma with an unclear resection margi

Agnostids afford the best means of correlating Cambrian strata, and they are widely used for intercontinental correlations. They are most common in open-marine deposits and reached a maximum diversity during the Middle and early Late Cambrian. About twenty species of agnostids are known from the Upper Cambrian of Scandinavia. Lotagnostus? mystacinus Tjernvik, 1953 is a rare agnostid from the Upper

Popular Abstract in Swedish Denna avhandling är resultatet av ett doktorandprojekt vid Kvartärgeologiska avdelningen, Lunds Universitet. Syftet med undersökningen var att rekonstruera vegetations- och klimatförändringar under de senaste 10 000 åren i Torneträskområdet i norra Sverige. Resultatet bygger på analyser av pollen och växtmakrofossil från 6 sjöar belägna på olika höjd över havet (370-999The aim of this study was to reconstruct the Holocene vegetation history and the climate changes in a subarctic area. The results are based on pollen and macrofossil records from six lakes in the Torneträsk area. The lakes are situated at altitudes between 370 and 999 m a.s.l., along a transect from the boreal pine-birch forest to the alpine tundra with heath vegetation. The chronology in each lak

Popular Abstract in Swedish Områden som är kontinuerligt utsatta för vinderosion löper stor risk för att erhålla en försämrad jordkvalitet eftersom vinderosion innebär en utsållning av fina fraktioner och humus från jordmånen. För att vinderosion ska inträffa krävs en kombination av vissa väder- och markförhållanden. Flera av dessa är direkt relaterade till klimatet, t ex vindhastighet och jordfukWind erosion is a serious threat to soil resources as it causes depletion of the fine fractions that may result in a less fertile soil. Wind erosion encompasses several processes of which many are related to climate variables. To date, there is little work performed on how wind erosion relates to climate and climate change. In this thesis, atmospheric circulation and wind erosion were analysed to