The epimerization of glucuronic acid into iduronic acid adds structural variability to chondroitin/dermatan sulfate polysaccharides. Iduronic acid-containing domains play essential roles in processes such as coagulation, chemokine and morphogen modulation, collagen maturation, and neurite sprouting. Therefore, we generated and characterized, for the first time, mice deficient in dermatan sulfate e

Background: A varying response to cholinesterase inhibitor (ChEI) treatment has been reported among patients with Alzheimer's disease (AD). Whether the individual-specific response, specific ChEI agent or dose affects mortality is unclear. We aimed to examine the relationship between the 6-month response to ChEI and lifespan. Methods: Six hundred and eighty-one deceased patients with a clinical AD

The development of a ternary AlxIn1-xP shell grown around GaAs nanowires epitaxially grown in the [(1) over bar (1) over bar (1) over bar] direction has been studied. Morphology and composition of the shell have been studied using cross-sectional transmission electron microscopy (TEM). The side facets of the shell are found to develop dominant {1 (1) over bar 0} macro facets with small (approx. 5

The aim of this article is to describe and analyse the working conditions of interpreters and interpreting services in Sweden. An understanding of interpreters' working conditions is a key to such factors as the management of resources, the reading and implementation of legislation, the organisation of interpreting services and the performance of interpreters in different situations. An understand

The ALICE Collaboration reports the measurement of the relative J/psi yield as a function of charged particle pseudorapidity density dN(ch)/d eta in pp collisions at root s = 7 TeV at the LHC. J/psi particles are detected for p(t) > 0, in the rapidity interval vertical bar y vertical bar < 0.9 via decay into e(+)e(-), and in the interval 2.5 < y < 4.0 via decay into mu(+)/mu(-) pairs. An approxima

We present dc and RF characterization of InAs nanowire field-effect transistors (FETs) heterogeneously integrated on Si substrates in a geometry suitable for circuit applications. The FET consists of an array of 182 vertical InAs nanowires with about 6-nm HfO high-gate dielectric and a wrap-gate length of 250 nm. The transistor has a transconductance of 155 mS/mm and an on-current of 550 mA/mm at

Aims: Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) is a widely used biomarker of oxidative stress. However, variability between chromatographic and ELISA methods hampers interpretation of data, and this variability may increase should urine composition differ between individuals, leading to assay interference. Furthermore, optimal urine sampling conditions are not well defined. We perform

Objective. With the increase in robotic-assisted laparoscopic surgery there is a concomitant rising demand for training methods. The objective was to establish face and construct validity of a novel virtual reality simulator (dV-Trainer, Mimic Technologies, Seattle, WA) for the use in training of robot-assisted surgery. Methods. A comparative cohort study was performed. Participants (n = 42) were

Recension av Wendy Lower, Hitlers furier : tyska kvinnor i förintelsens tjänst

The objectives were to investigate (i) the forms and release pattern of P from an ash-rich biochar-amended sandy soil; (ii) the transformation of biochar P in a soil-plant system. Several methodologies (a bioassay test, soluble P extractions, a sequential P fractionation and successive P extractions via resin strips) were used to study the bioavailability and transformation of P in a sandy soil

This paper presents a structured methodology for the constrained multi-objective optimization (MO) of a continuous cross-flow atomic layer deposition (ALD) reactor model with temporal precursor pulsing. The process model has been elaborated and experimentally validated in the first two papers of this series (33 and 34). A general constrained MO problem (MOP) was formulated to simultaneously optimi

The inverse problem for Schrodinger operators on metric graphs is investigated in the presence of magnetic field. Graphs without loops and with Euler characteristic zero are considered. It is shown that the knowledge of the Tachmarsh-Weyl matrix function (Dirichletto-Neumann map) for just two values of the magnetic field allows one to reconstruct the graph and potential on it provided a certain ad

Popular Abstract in Swedish Hepatit C är idag den ledande orsaken till kronisk leversjukdom i västvärlden och även den vanligaste anledningen till levertransplantation. Sjukdomen orsakas av hepatit C-virus (HCV) och överförs i de flesta fall via blod. Majoriteten av de smittade (50-80%) kommer att utveckla en kronisk HCV-infektion. Den ständigt pågående inflammation som virusinfektionen orsakar iThe hepatitis C virus (HCV) is a blood borne virus effectively spread through injection practices. Consequently, people who inject drugs (PWID) are at the center of the current HCV epidemic in industrialized countries, with regards both to prevalence and incidence. Through progressive liver fibrosis, chronic HCV infection conveys a substantial risk of liver cirrhosis and end-stage liver disease. T

Sweden experienced an increase in the ratio of granted patents to research and development spending (R&D) between 1989 and 1998, a period when R&D spending grew rapidly. The ratio of patents granted to R&D spending (research productivity) increased by 40% over the period, and the ratio of quality-adjusted patents to R&D exhibited an even more impressive increase of 60%. Sectors wit

A hybrid plasmonic waveguide consisting of a high-index dielectric core embedded inside a rectangular-shaped metallic trench is proposed and its guiding properties are investigated at the wavelength of 1550 nm. Numerical simulations based on the finite element method have demonstrated that the introduced dielectric core could greatly reduce the modal loss of the metal trench while maintaining stro

Solution and adsorption properties of both charged and uncharged bottle-brush polymers have been investigated. The solution conformation and interactions in solution have been investigated by small-angle scattering techniques. The association of the bottle-brush polymers with anionic surfactants has also been studied. Surfactant binding isotherm measurements, NMR, surface tension measurements, as

Popular Abstract in Swedish Under den nuvarande värmeperioden (holocen) som inleddes för ca 11 600 år sedan, har klimatet i den nordatlantiska regionen varierat på både korta och långa tidsskalor. Orsaken till dessa variationer är många och komplexa, men kan till viss del relateras till temporära förändringar i havsströmmar och den atmosfäriska cirkulationen. Den termohalina cirkulationen, som delThe North Atlantic region has experienced significant climate fluctuations during the Holocene. It has been shown that these fluctuations affected the terrestrial environment in Iceland, including its glaciers and ice caps. However, the full Holocene development of Icelandic glaciers, including the large Vatnajökull ice cap and its outlet glaciers, is not fully known. In this thesis, a sediment se

Cyber-physical systems react on events reported by sensors and interact with objects of the real world according to their current state and their view of the world. This view is naturally represented by a model which is continuously analysed and updated at runtime. Model analyses should be ideally concise and efficient, requiring well-founded, comprehensible implementations with efficient reasonin