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During development, hematopoietic cells originate from endothelium in a process known as endothelial-to-hematopoietic transition (EHT). To study human EHT, we coupled flow cytometry and single-cell transcriptional analyses of human pluripotent stem cell-derived CD34(+) cells. The resulting transcriptional hierarchy showed a continuum of endothelial and hematopoietic signatures. At the interface of
The devices that constitute the Internet of Things are evolving to include more than just enabling sensing and actuation over a wireless interface. In a contemporary scenario, these devices perform tasks and contribute to an aggregate information flow, in a distributed manner. In the wake of this evolution, new distributed Internet of Things frameworks have emerged. These frameworks maintain a dis
We invite you to explore and contribute to this free online archive on cultures, histories, activities, and spaces related to drugs. The Narcotic City Archive collects and preserves the heritage of substance use and many associated social, cultural, economic, and political issues. We aim to gather a wide range of historical and contemporary materials from different groups and inviduals – and we ho
Interferon gamma (IFNγ) is central to the inflammatory immune response, such as that entrained by BCG immunotherapy for bladder cancer. However, immune-mediated tumour cell killing is subject to modulation by immunoinhibitory “checkpoint” receptors such as PD-L1. We investigated the effects of IFNγ on barrier-forming in vitro-differentiated normal human urothelium using mRNA-sequencing, and showed
Studier i retlig bevidsthed analyserer personers oplevelser, forståelser og handlinger relateret til deres retlige kontekst og viser, hvor mangfoldig og foranderlig retlig bevidsthed kan være som følge af retlig bevidstheds subjektive karakter. Tidligere litteraturstudier understreger retlig bevidstheds iboende forskellighed og fokuserer særligt på metodologiske fællestræk eller fællestræk indenfo
By tradition, L2 motivation research has a monolingual bias – the motivational systems of a learner’s different languages conceptualized as separate entities rather than as cognitively interconnected. At a time when multilingualism has become a new world order (Douglas Fir Group, ) and where there is evidence of powerful identity experiences connected to speaking several languages (Pavlenko, ) thi
This thesis summarizes the experimental work in which an ultrafastX-ray laser plasma source was combined with variousscalable direct detection schemes to test a novel approach forlab-based time-resolved X-ray absorption spectroscopy. A laserplasma source based on a water jet target was built and commissioned.X-ray and electron emissions of this source were characterizedwith various direct detectio
L-DOPA remains the gold-standard treatment for Parkinson's disease but causes motor fluctuations and dyskinesia. Metabotropic glutamate receptor type 5 (mGluR5) has been proposed as a target for antidyskinetic therapies. Here, we evaluate the effects of fenobam, a noncompetitive mGluR5 antagonist already tested in humans, using rodent and nonhuman primate models of L-DOPA-induced dyskinesia. In bo
The polyamines are essential for cancer cell proliferation during tumorigenesis. Targeted inhibition of ornithine decarboxylase (ODC), i.e. a key enzyme of polyamine biosynthesis, by alpha-difluoromethylornithine (DFMO) has shown anti-neoplastic activity in various experimental models. This activity has mainly been attributed to the anti-proliferative effect of DFMO in cancer cells. Here, we provi
Introduction: The Chilean Society of Bariatric and Metabolic Surgery, together with other scientific societies, led a process for adapting the Canadian clinical practice guideline for obesity in adults for Chile. The aim of the Canadian guideline, among its main objectives, was to propose changes in obesity management using a chronic disease framework and focusing on improving patient-centered hea
Electrical storm (ES) presents a difficult management problem that has predominantly been described in adults and there are limited published data relating to children. We set out to characterize ES in children to assist management based on published literature and own institutional experience. We retrospectively analyzed the records of children presenting with ES to our institution between July 2
This article critically explores responses to the suffering of animals caused by industrialised agriculture aiming to reflect on broader aspects of the current state of animal politics in the 21st century. Focusing on the regulatory schemes introduced to control the welfare of animals in Denmark, the article foregrounds sites of law enforcement and industry regulation, in which animal suffering is
Many induced mutants are available in barley (Hordeum vulgare L.). One of the largest groups of induced mutants is the Erectoides (ert) mutants, which is characterized by a compact and upright spike and a shortened culm. One isolated mutant, ert-k.32, generated by X-ray treatment and registered in 1958 under the named “Pallas”, was the first ever induced barley mutant to be released on the market.
