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Thymic expression of insulin has been suggested to play a major role in negative selection of autoreactive T cells and tolerance induction against pancreatic beta cells. Furthermore, the expression of insulin in peripheral antigen-presenting cells (APC) has been clearly demonstrated but whether thymic negative selection and tolerance induction also depends on peripheral influx of self-antigens (Ag
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The prospects for patients suffering from systemic small vessel vasculitis have improved substantially in recent decades. The introduction of cyclophosphamide in the 1970s led to a dramatic improvement in survival rates. The discovery of ANCA meant a substantial increase in the number of detected cases, especially among elderly patients, as well as detection at an earlier stage of disease. At the
An analysis of the content of the treatise on the popes edited by Alfonso of Jaén.
The morphology and the anatomy of the 13 species presently included in the genus Fulgensia were surveyed. Caloplaca aurea and C. paulii, two speciesregarded as closely related to Fulgensia by earlier authors, were also included in the study. Fulgensia was found to exhibit a great variation in both morphology and anatomy. The differences in size, shape and septation of the spores, in the anatomy of
Violaxanthin deepoxidase (VDE) has been purified from spinach (Spinacia oleracea) leaves. The purification included differential sonication of thylakoid membranes, differential (NH4)2SO4 fractionation, gel filtration chromatography and finally either hydrophobic interaction chromatography or anion exchange chromatography. A total purification of more than 5000-fold compared to the original thylako
A key premise of the heuristics-and-biases program is that heuristics are “quite useful.” Let us now pay more than lip service to this premise, and analyse the environmental structures that make heuristics more or less useful. Let us also strike from the long list of biases those phenomena that are not biases and explore to what degree those that remain are adaptive or can be understood as by-prod
Abstract is not available
