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For patients with end-stage respiratory diseases, such as COPD, interstitial lung diseases and cystic fibrosis, lung transplantation remains the only treatable option. However, due to increasing demand and limited availability of donor lungs, risk of complications such as acute and chronic rejection, and adverse effects of immunosuppressive treatments, this is not an alternative for the majority o
Subcellular membrane systems are highly enriched in dolichol, whose role in organelle homeostasis and endosomal-lysosomal pathway remains largely unclear besides being involved in protein glycosylation. DHDDS encodes for the catalytic subunit (DHDDS) of the enzyme cis-prenyltransferase (cis-PTase), involved in dolichol biosynthesis and dolichol-dependent protein glycosylation in the endoplasmic re
We describe a new cause of congenital disorder of glycosylation-Ic (CDG-Ic) in a young girl with a rather mild CDG phenotype. Her cells accumulated lipid-linked oligosaccharides lacking three glucose residues, and sequencing of the ALG6 gene showed what initially appeared to be a homozygous novel point mutation (338G>A). However, haplotype analysis showed that the patient does not carry any patern
We have carried out a comprehensive molecular mapping of PG-M/versican isoforms V0-V3 in adult human tissues and have specifically investigated how the expression of these isoforms is regulated in endothelial cells in vitro. A survey of 21 representative tissues highlighted a prevalence of V1 mRNA, demonstrated that the relative frequency of expression was V1>V2>V3greater than or equal toV2; and s
Discussion concerning school and cultural change
In wavefield signal apparition, acquisition with periodic variations in source activation parameters shifts all or part of a signal cone out to, e.g., the Nyquist wavenumber, enabling perfect separation of simultaneous-source (sim-source) data below a certain temporal frequency. Cyclic convolution in the spatial frequency domain is used to generalise the signal apparition concept to the case of ap
Urban populations are growing rapidly with several environmental and social effects in the process. At a governance level, resources go from being regulated by federal and state institutions into being considered urban areas governed by the local government. Nevertheless, this can neglect the enforcement of existing laws for many reasons that deteriorate urban resources due to a rivalry in the typ
Fotosyntetiserande växter, alger och bakterier fångar in och omvandlar solenergi till kemisk energi. Själva ljusinfångningen involverar olika pigment, varav de mest kända är de gröna klorofyllmolekylerna som förekommer i olika varianter (varav två varianter kallade klorofyll A respektive B förekommer hos högre växter). De ljusinfångande pigmenten inkluderar även de mer mångtaliga karotenoiderna, ePhotosynthetic organisms harvest and convert light energy into chemical energy and utilize it in their metabolism. The light is captured through pigments called chlorophylls and carotenoids, present in the thylakoid membranes inside the chloroplast. In addition to acting as auxiliary light harvesters, the carotenoids also act as antioxidants by 1) preventing the formation of reactive oxygen specie
The effects of global warming are apparent and the work towards a sustainable future is underway. In order to reduce the environmental impact caused by the transportation sector, a transition from fossil fuels to those based on renewable resources are important. Using agricultural land to produce raw materials, e.g. wheat or corn, for biofuel is controversial as it competes with food production. F
