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INTRODUCTION: Inequity in stroke care in Europe has previously been reported despite the existence of evidence-based cost-effective interventions for both prevention and treatment. This report aims to provide comprehensive data on stroke care in Europe in 2023 and explore associations to European regions, organisational and economic factors. PATIENTS AND METHODS: The Stroke Service Tracker, an ann
Crises narratives surrounding the societal challenges of biodiversity loss, climate change, and human health and well-being dominate current debates in global environmental politics. These challenges are deeply interconnected and require transformative and integrated change. Marine and coastal Nature-based Solutions (blue NbS) are an opportunity to minimise harmful human impacts on these ecosystem
Time-resolved imaging of plasmonic near fields is well-established at visible wavelengths but remains largely unexplored in the short-wavelength infrared (SWIR) range. Here, we use time-resolved photoemission electron microscopy (TR-PEEM) to directly visualize ultrafast plasmon dynamics in silver nanowires driven by a few-cycle SWIR pulses. We observe strong electric-field enhancement localized at
Most flowering plants depend on insect pollinators for their reproduction, yet these pollinators have been facing considerable losses in abundance and diversity in recent decades. The ongoing pollinator declines, caused by stressors including land-use and climate change, have raised concerns for species-rich plant communities such as those found in semi-natural grasslands. These communities contai
We simulate hadrons impinging on a homogeneous lead tungstate ((Formula presented.)) calorimeter using GEANT4 software to investigate how the resulting light yield and its temporal structure, as detected by an array of light-sensitive sensors, can be processed by a neuromorphic computing system. Our model encodes temporal photon distributions as spike trains and employs a fully connected spiking n
Regulation of intracellular levels of reactive oxygen species (ROS) remains poorly understood. Aquaporin 3 (AQP3) facilitates the membrane transport of hydrogen peroxide (H2O2), a key ROS signaling molecule. Here we elucidate the molecular mechanism of AQP3 and show that its regulatory properties are both pH dependent and autoregulated by H2O2. Using single particle cryo-electron microscopy, we pr
Based on data obtained with the Eurogam spectrometer, a systematic investigation of superdeformed bands built on single neutron excitations across the N = 86 shell gap has been carried out for gadolinium, terbium, and dysprosium isotopes with 85 ≤ N ≤ 87. In each nucleus, pairs of bands corresponding to degenerate signature partners have been observed. The effective alignment is constant and close
Chagas disease (CD), caused by Trypanosoma cruzi, is a neglected tropical illness affecting 6-8 million people in Latin America. Reaching scholarly consensus on the host response to T. cruzi infection remains a significant challenge, primarily due to substantial heterogeneity in outcomes driven by both the choice of animal model and the infecting parasite's discrete typing unit (DTU). This var
Fencing to exclude livestock is one of the effective strategies to passively reshape grassland ecosystem function, yet the dynamics of microbial community construction and their functional traits during restoration remain poorly understood. This study systematically sampled from various microhabitats (phyllosphere, litter, soil) within long-term fenced restoration areas, as well as areas with pers
Spindle cell lipomas (SCL) and pleomorphic lipomas (PL) are today considered a single tumor entity (SCLPL). Atypical SCLPL, in contrast, represents a recently recognized related but distinct entity. Here we explored the correlation between genomic features and morphological aspects of SCLPL and atypical SCLPL and the role of the RB1 gene in tumor development. Seventy-one samples from 68 patients w
Components of dissolved organic matter (DOM) span from sub-nm molecules to colloidal aggregates of several hundred nm. The colloidal fraction is important for the transport of organic matter and associated elements in the environment, and for the stability of DOM constituents with respect to microbial decomposition. This study focuses on the colloidal properties of DOM extracted from spruce forest
AIM: A survival benefit has been observed for colorectal cancer patients with peritoneal carcinomatosis treated by cytoreductive surgery with intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC). However, this treatment modality is associated with a considerable morbidity and mortality and in a significant number of patients survival is not improved. We studied whether poor survivors c
INTRODUCTION: It is unclear how different proteinopathies (tau, transactive response DNA-binding protein 43 [TDP-43], amyloid β [Aβ], and α-synuclein) contribute to atrophy within medial temporal lobe (MTL) subregions in Alzheimer's disease (AD).METHODS: We utilized antemortem structural magnetic resonance imaging (MRI) data to measure MTL substructures and examined the relative contribution of ta
The #FridaysForFuture climate protests mobilized more than 1.6 million people around the globe in March 2019. Through a school strike, a new generation has been galvanized, representing a historical turn in climate activism. This wave of climate protest mobilization is unique in its tactics, global scope and appeal to teenage school students. Media coverage of these protests and high-level nationa
Cells continuously sense external forces from their microenvironment, the extracellular matrix (ECM). In turn, they generate contractile forces, which stiffen and remodel this matrix. Although this bidirectional mechanical exchange is crucial for many cell functions, it remains poorly understood. Key challenges are that the majority of available matrices for such studies, either natural or synthet
Halite (NaCl mineral) has exhibited the potential to preserve microorganisms for millions of years on Earth. This mineral was also identified on Mars and in meteorites. In this study, we investigated the potential of halite crystals to protect microbial life-forms on the surface of an airless body (e.g., meteorite), for instance, during a lithopanspermia process (interplanetary travel step) in the
BACKGROUND AND AIMS: Systolic blood pressure (SBP) drops recorded by 24-hour ambulatory blood pressure (BP) monitoring (ABPM) identify patients with susceptibility to reflex syncope and orthostatic intolerance. We tested the hypothesis that treatments aimed to increase BP (reassurance, education & life-style measures plus pharmacological strategies) can reduce SBP drops.METHODS: Multicentre, o
Filaggrin (FLG), a skin barrier protein, is associated with higher dermal uptake of some chemicals in carriers of loss-of-function (null) mutations. This study investigates FLG mutations and systemic effects following dermal exposure to chemicals. Individuals (n = 23 FLG null, n = 31 FLG wt) were simultaneously exposed to pyrimethanil, pyrene, oxybenzone, and nickel ions for 4 h. Pre- and post-exp
Cancer invasion and metastasis are known to be potentiated by the expression of aquaporins (AQPs). Likewise, the expression levels of AQPs have been shown to be prognostic for survival in patients and have a role in tumor growth, edema, angiogenesis, and tumor cell migration. Thus, AQPs are key players in cancer biology and potential targets for drug development. Here, we present the single-partic
Background: Treatment of childhood glioma has evolved to reduce radiotherapy exposure with the goal of limiting late toxicity. However, the associations between treatment changes and neurocognition, and the contribution of neurocognition and chronic health conditions to attainment of adult independence, remain unknown. Methods: Adult survivors of childhood glioma diagnosed in 1970-1999 in the Chil
