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In preparation for future, large-scale, multi-object, high-resolution spectroscopic surveys of the Galaxy, we present a series of tests of the precision in radial velocity and chemical abundances that any such project can achieve at a 4 m class telescope. We briefly discuss a number of science cases that aim at studying the chemo-dynamical history of the major Galactic components (bulge, thin and

Acute myeloid leukemia with t(6; 9)(p22; q34) is listed as a distinct entity in the 2008 World Health Organization classification, but little is known about the clinical implications of t(6; 9)-positive myeloid leukemia in children. This international multicenter study presents the clinical and genetic characteristics of 62 pediatric patients with t(6; 9)/DEKNUP214-rearranged myeloid leukemia; 54

The Gaia-ESO survey is a large public spectroscopic survey aimed at investigating the origin and formation history of our Galaxy by collecting spectroscopy of representative samples (about 105 Milky Way stars) of all Galactic stellar populations, in the field and in clusters. The survey uses globular clusters as intra-and inter-survey calibrators, deriving stellar atmospheric parameters and abunda

Objectives: Core CSF changes in Alzheimer disease (AD) are decreased amyloid beta(1-42), increased total tau, and increased phospho-tau, probably indicating amyloid plaque accumulation, axonal degeneration, and tangle pathology, respectively. These biomarkers identify AD already at the predementia stage, but their diagnostic performance might be affected by age-dependent increase of AD-type brain

A general question for linkage disequilibrium-based association studies is how power to detect an association is compromised when tag SNPs are chosen from data in one population sample and then deployed in another sample. Specifically, it is important to know how well tags picked from the HapMap DNA samples capture the variation in other samples. To address this, we collected dense data uniformly

IL-5 is a Th2 cytokine which activates eosinophils and is suggested to have an atheroprotective role. Genetic variants in the IL5 locus have been associated with increased risk of CAD and ischemic stroke. In this study we aimed to identify genetic variants associated with IL-5 concentrations and apply a Mendelian randomisation approach to assess IL-5 levels for causal effect on intima-media thickn

Introduction. There are few published guidelines for the management of sexual dysfunctions in men and women, despite the prevalence and lack of attention to these problems. Disorders of sexual function in men include erectile dysfunction, orgasm/ejaculation disorders, priapism, and Peyronie's disease. Aim. To provide evidence-based and expert-opinion consensus guidelines for the clinical managemen

It is difficult to obtain fossil data from the 10% of Earth's terrestrial surface that is covered by thick glaciers and ice sheets, and hence, knowledge of the paleoenvironments of these regions has remained limited. We show that DNA and amino acids from buried organisms can be recovered from the basal sections of deep ice cores, enabling reconstructions of past flora and fauna. We show that high-

We report on "safe" Coulomb excitation of neutron-rich (138,140,142) Xe nuclei. The radioactive nuclei have been produced by ISOLDE at CERN and post-accelerated by the REX-ISOLDE facility. The gamma-rays emitted by the decay of excited states have been detected by the MINIBALL array. Recent results are presented.

Grass pollen is the world’s most harmful outdoor aeroallergen. However, it is unknown how airborne pollen assemblages change across time and space. Human sensitivity varies between different species of grass that flower at different times, but it is not known whether temporal turnover in species composition match terrestrial flowering or whether species richness steadily accumulates over the grass

We write with great concern in response to the recent systematic review and meta-analysis of cognitive-behavioral therapy (CBT) in pediatric obsessive-compulsive disorder (OCD) by Uhre et al.1 Although the authors’ results consistently support the clinical efficacy of CBT for pediatric OCD, we expect that, much like ourselves, readers will be confused by the discordant and inappropriate conclusion

Results from the first soft X-ray user experiment at the European XFEL on nonlinear photon-matter interaction will be presented. Angle-resolved electron time-of-flight spectroscopy employed at the AQS (Atomic- like Quantum Systems) endstation of the SQS (Small Quantum Systems) instrument reveals insight into the character of resonances in highly transient, core ionized neon ions, i.e. Ne:+ 1s12s22

BACKGROUND: Tuberous sclerosis complex (TSC)-associated neuropsychiatric disorders (TAND) have unique, individual patterns that pose significant challenges for diagnosis, psycho-education, and intervention planning. A recent study suggested that it may be feasible to use TAND Checklist data and data-driven methods to generate natural TAND clusters. However, the study had a small sample size and da

The aggregation of simulated gridded crop yields to national or regional scale requires information on temporal and spatial patterns of crop-specific harvested areas. This analysis estimates the uncertainty of simulated gridded yield time series related to the aggregation with four different harvested area data sets. We compare aggregated yield time series from the Global Gridded Crop Model Interc

The formation of new atmospheric particles involves an initial step forming stable clusters less than a nanometre in size (<~1 nm), followed by growth into quasi-stable aerosol particles a few nanometres (~1-10 nm) and larger (>~10 nm). Although at times, the same species can be responsible for both processes, it is thought that more generally each step comprises differing chemical contributors. H

In Sweden, the pedagogical training of doctoral students varies significantly across universities. While most institutions include at least one mandatory course in higher education teaching and learning, some programs lack this requirement entirely. Whether doctoral students are encouraged or even allowed to take multiple pedagogical courses also varies greatly. This paper explores the benefits ofIn Sweden, the pedagogical training of doctoral students varies significantly across universities. While most institutions include at least one mandatory course in higher education teaching and learning, some programs lack this requirement entirely. Whether doctoral students are encouraged or even allowed to take multiple pedagogical courses also varies greatly. This paper explores the benefits of

High-flux hemodialysis (HD) and high-dose hemodiafiltration (HDF) are established treatments for patients with kidney failure. Since HDF has been associated with improved survival rates compared to HD, we evaluated the cost-effectiveness of HDF compared to HD. Cost–utility analyses were performed from a societal perspective alongside the multinational randomized controlled CONVINCE trial. A Markov

Introduction: Impacts of climate change on human health receive increasing attention. However, the connections of climate change with well-being and mental health are still poorly understood.Objective: As part of the Horizon Europe project TRIGGER, we aim to deepen the understanding of the relationships between climate change and human mental health and well-being in Europe by focusing on environm

Dynamic interference is an elusive strong-field effect where photoelectrons from intense laser pulses interfere in time, forming rich kinetic energy patterns. Here, we present the first experimental demonstration of isolated dynamic interference using a novel two-color scheme: chirped laser-assisted dynamic interference. Isolation was achieved with a crossed-polarization setup combining an extreme

Biocompatibility studies, especially innate immunity induction, in vitro and in vivo cytotoxicity, and fibrosis, are often lacking for many novel biomaterials including recombinant protein-based ones, such as elastin-like recombinamers (ELRs), and has not been extensively explored in the scientific literature, in contrast to traditional biomaterials. Herein, we present the results from a set of ex