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Harvesting the decay energy of 26 Al to drive lightning discharge in protoplanetary discs

Chondrules in primitive meteorites likely formed by recrystallisation of dust aggregates that were flash-heated to nearly complete melting. Chondrules may represent the building blocks of rocky planetesimals and protoplanets in the inner regions of protoplanetary discs, but the source of ubiquitous thermal processing of their dust aggregate precursors remains elusive. Here we demonstrate that esca

β-Mannan degradation by gut bacteria - Characterization of β-mannanases from families GH5 and GH26

Popular Abstract in Swedish Människan lever inte bara själv, utan tillsammans med en mängd bakterier som lever i kroppen. Större delen av dessa lever i tjocktarmen. Dessa organismer är viktiga för vår hälsa. De stimulerar immunförsvaret, sänker pH i tarmen och gör det ogynnsamt för sjukdomsframkallande bakterier att växa till. Bakterierna lever i symbios med oss och med varandra. Förändringar i taThe human gut flora is important for our well-being. The gut bacteria are able to degrade and metabolize complex carbohydrates. Examples of such carbohydrates are β-mannans. β-Mannans consist of a backbone of β-1,4-linked mannose units and are present in e.g. the endosperm of legumes such as guar or carob. The composition of the β-mannan varies with the plant source. Carob and guar β-mannans are s

The neutrophil-mobilizing cytokine interleukin-26 in the airways of long-term tobacco smokers

Long-term tobacco smokers with chronic obstructive pulmonary disease (COPD) or chronic bronchitis display an excessive accumulation of neutrophils in the airways; an inflammation that responds poorly to established therapy. Thus, there is a need to identify new molecular targets for the development of effective therapy. Here, we hypothesized that the neutrophil-mobilizing cytokine interleukin (IL)

Risk Factors for Septic Arthritis After Anterior Cruciate Ligament Reconstruction : A Nationwide Analysis of 26,014 ACL Reconstructions

Background: Septic arthritis (SA) after anterior cruciate ligament reconstruction (ACLR) is a rare yet severe complication. The samples in previous studies have been small and without nationwide coverage, making analysis uncertain with a risk of bias. Conclusions to recommend preventive measures are therefore difficult to draw, and it has not been possible to perform a comprehensive risk factor an

Eotaxin-3 (CCL26) exerts innate host defense activities that are modulated by mast cell proteases

BackgroundDuring bacterial infections of the airways, a Th1-profiled inflammation promotes the production of several host defense proteins and peptides with antibacterial activities including -defensins, ELR-negative CXC chemokines, and the cathelicidin LL-37. These are downregulated by Th2 cytokines of the allergic response. Instead, the eosinophil-recruiting chemokines eotaxin-1/CCL11, eotaxin-2