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Vad bör en forensisk expert inte uttala sig om?

Mitt syfte med uppsatsen är att undersöka hur väl forensikers egen uppfattning om vad de bör uttala sig om och vad de inte bör uttala sig om stämmer överens med en idealbild av expertrollen. Mot bakgrund av syftet ställdes elva påståenden till 50 forensiska experter vid Nationellt forensiskt centrum (NFC) i form av en enkätundersökning. De sätt på vilka forensiker kan avvika från idealet som testa

Liver-related complications and metabolic comorbidities during long-term follow-up of patients with Non-Alcoholic Fatty Liver Disease

Background: Non-alcoholic fatty liver disease (NAFLD) is highly associated with the metabolic syndrome, and due to increasing prevalence of for example obesity it is now the most common liver disease in the world. A minority progress to advanced fibrosis/cirrhosis, which is associated with increased mortality, but it is not entirely clear which patients who have an increased risk of fibrosis.Gener

Performance-based costing as decision support for development of discrete part production : Linking performance, production costs and sustainability

Svensk tillverkningsindustri bidrar till ca 16 % (Statistics Sweden 2016) av bruttonationalprodukten och medverkar till att ca 900 000 av landets invånare har en anställning (Produktion2030 2016), vilket gör sektorn till en viktig del av Sveriges välfärdssystem. Forskningen syftar främst till att ge industrin verktyg för att analysera och utvärdera produktion för resurseffektivare och lönsammare tIn today’s global market, the industry is struggling every day to make the “correct decisions”. Decisions concerning production can range from smaller improvements to choice tool or equipment investments to relocation of entire production facilities. Increasing globalization leads to both opportunities and challenges, driving the need for fact-based decision-support including costs to be able to e

Situating Faculty Development in the Clinical Workplace

Medical students’ access to clinical supervision when rotating through hospital workplaces and the quality of that supervision are and have been an area of growing professional and societal concern. Increased training measures targeted at supervising physicians have been suggested to address this issue. Traditionally, such training has focused on offering physicians opportunities to develop as sup

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis

Background: Glycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and assess glycemic control in patients with diabetes. Previous genome-wide association studies (GWAS) have identified 18 HbA1c-associated genetic variants. These variants proved to be classifiable by their likely biological action as erythrocytic (also associated with erythrocyte traits) or glycemic (associated with

Incident diabetes mellitus may explain the association between sleep duration and incident coronary heart disease

Aims/hypothesis: Sleep duration is a risk factor for incident diabetes mellitus and CHD. The primary aim of the present study was to investigate, in sex-specific analyses, the role of incident diabetes as the possible biological mechanism for the reported association between short/long sleep duration and incident CHD. Considering that diabetes is a major risk factor for CHD, we hypothesised that a

Processing and Storage stability of Skim Milk Powder : Monitoring Early and Advanced Stages of the Maillard Reaction

The non-enzymatic browning known as the Maillard reaction has been the subject of extensive investigation for decades. Studies have focused on areas such as changes in flavour, colour, texture, and the nutritional properties of food materials as a result of this reaction. However, this complex reaction between the amino acids in proteins and reducing sugars in carbohydrates, is still not fully und

Hemicellulose isolation from thermomechanical pulp mill process water using UF: Optimisation and economics

Every year, 100,000 tons of dissolved hemicelluloses are discharge unused with wastewater from thermomechanical pulp mills around the world. Isolation of these hemicelluloses from the wastewater would not only reduce the treatment costs for the pulp mills but would also provide an excellent raw material for high value applications such as oxygen barriers in food packaging. The isolation of the hem

Assessment of cognition in ageing. Investigating internal validity, occurrence and reversion of Mild Cognitive Impairment. Data from the general population study “Good Aging in Skåne”

Bakgrund Med en snabbt växande äldre populationsgrupp kommer även andelen med kognitiva störningar, som demens, att växa. Det är således nödvändigt med forskning på kognition och åldrande. Denna avhandling, genom fyra delarbeten, redogör för testledareffekter vid kognitionsmätningar och hur yngre födelsekohorter (generationer) presterar bättre än äldre på kognitionstester. Den kommer även förklaraGiven a growing population of older adults and the common occurrence of natural as well as pathological cognitive decline, i.e. dementia, there is a need to better understand how to accurately measure and classify level of cognitive functioning. Both using multiple test administrators to collect cognitive data and what year the participant is born (birth cohort effects) can influence participants’

Apolipoprotein A-I in glucose metabolism and amyloidosis

The role of Apolipoprotein A-I (ApoA-I), the main protein component of HDL, in cholesterol transport and metabolism is well known and has been studied for more than four decades. More recently, ApoA-I protein has been shown to also have a positive role in glucose control by both stimulation of glucose uptake by muscles and by increasing glucose-stimulated pancreatic insulin secretion. Two of the f

Remote sensing of grassland communities : integrated effects of soil nutrients and habitat age

Semi-natural grasslands are characterized by high fine-scale plant species richness. The richest grassland communities, with many habitat-specialist species, are found in ancient grassland sites that have a long continuity of grazing management and low levels of soil nutrients. Grazed grasslands were widespread in the historical landscape. Agricultural intensification over the last two centuries h

Performance of Fully Automated Plasma Assays as Screening Tests for Alzheimer Disease-Related β-Amyloid Status

Importance: Accurate blood-based biomarkers for Alzheimer disease (AD) might improve the diagnostic accuracy in primary care, referrals to memory clinics, and screenings for AD trials. Objective: To examine the accuracy of plasma β-amyloid (Aβ) and tau measured using fully automated assays together with other blood-based biomarkers to detect cerebral Aβ. Design, Setting, and Participants: Two pros

Why should we teach tourism at universities?

Why should we teach tourism at universities?This presentation targets the question of why tourism should be part of university education. Presently, this is questioned by colleagues in traditional academic disciplines as well as by parts of the tourism industry, which are somewhat reluctant to employ people with a university degree. It is thus time for this matter to be raised. If we are to answer

Biogeochemistry in Subarctic birch forests : Perspectives on insect herbivory

Växtätare kan påverka ekosystemprocesser, dels genom långsiktiga förändringar av växtsamhällets sammansättning, men också på kortare sikt genom derasmatspjälkning av organiskt material som cyklas genom markens nedbryderorganismer och tillbaka till de primära producenterna. Särskilt störreväxtätare har studerats i stor utsträckning, men i vissa ekosystem som skogar kan de mindre ryggradslösa växtätHerbivory can influence ecosystem processes, partly through long-term changes of the plant community compositions, but also more rapidly through the herbivores’ digestive alteration of the organic matter that is cycled through the soil and back to the primary producers. In the Subarctic mountain birch (Betula pubescens ssp. czerepanovii) forest (SMBF) in Northern Fennoscandia, outbreaks by the geo

Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies

Background Genetic determinants of stroke, the leading neurological cause of death and disability, are poorly understood and have seldom been explored in the general population. Our aim was to identify additional loci for stroke by doing a meta-analysis of genome-wide association studies. Methods For the discovery sample, we did a genome-wide analysis of common genetic variants associated with inc

Microbial production of platform chemicals from glycerol

The chemical industry is primarily dependent on fossil oil and gas as raw materials. With increasing demands on reducing the greenhouse gas emissions and carbon footprint attributed to fossil based production, the industry looks for alternative renewable cleaner resources to secure the supplies for future chemical and material products. The current trend in the shift to bio-based economy aims at u

Evaluation of the European Society of Cardiology/European Respiratory Society derived three-and four-strata risk stratification models in pulmonary arterial hypertension : Introducing an internet-based risk stratification calculator

Aims: Estimation of prognosis in pulmonary arterial hypertension (PAH) has been influenced by that various risk stratification models use different numbers of prognostic parameters, as well as the lack of a comprehensive and time-saving risk assessment calculator. We therefore evaluated the various European Society of Cardiology (ESC)-/European Respiratory Society (ERS)-based three-and four-strata

Prolonged culture of human pancreatic islets under glucotoxic conditions changes their acute beta cell calcium and insulin secretion glucose response curves from sigmoid to bell-shaped

Aims/hypothesis: The rapid remission of type 2 diabetes by a diet very low in energy correlates with a marked improvement in glucose-stimulated insulin secretion (GSIS), emphasising the role of beta cell dysfunction in the early stages of the disease. In search of novel mechanisms of beta cell dysfunction after long-term exposure to mild to severe glucotoxic conditions, we extensively characterise

Solar access indicators for urban planning

Solar access describes the amount and distribution of sunlight in living environments. Access to sunlight is crucial for the health and sustainability of cities. It is vital for people and vegetation, and for energy production and conservation. The amount of sunlight entering the city space is restricted by the urban layout, as buildings obstruct solar access by shading each other and the surround