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The core feature of vascular ageing is the age-associated stiffening of the large, elastic arteries, or arteriosclerosis. This results in a diminished volume-buffering function and is therefore central for the increase in systolic blood pressure and pulse pressure seen with advancing age. Since there are considerable individual differences regarding the rate of vascular ageing, the aim was to desc

Windmill structures must withstand very high horizontal loading giving an extremely large overturning moment on the foundation. These structures have very low stability loads in comparison to the overturning loads. The traditional way to solve the construction problem uses a shallow foundation with a massive concrete volume or a piled foundation to resist the extreme overturning moment. This work

AIMS/HYPOTHESIS: Obesity during pregnancy increases offspring type 2 diabetes risk. Given that nearly half of women of child-bearing age in many populations are currently overweight/obese, it is key that we improve our understanding of the impact of the in utero/early life environment on offspring islet function. Whilst a number of experimental studies have examined the effect of maternal obesity

Human histo-blood groups are inherited polymorphic variants that occur in the molecular structures on the humanred blood cell (RBC) surface. Introducing foreign RBCs into a recipient lacking an antigen may activate the humoraldefence leading to a hemolytic transfusion reaction. Antigenic differences can also cause hemolytic disease of thefetus and newborn (HDFN). Blood group antigens are implicate

Improved understanding of the disease mechanisms underlying type 2 diabetes (T2D) is needed, and so are new treatments.A new T2D risk variant was recently identified in ADRA2A, which encodes the α2A-adrenergic receptor. The risk allele leads to receptor overexpression in β-cells that causes increased adrenergic signaling and impaired insulin secretion. We showed that the α2A-adrenergic receptor an

Hallmarks of type 2 diabetes (T2D) include elevated blood glucose and free fatty acids (FFAs) as a result of impaired β cell insulin secretion and decreased β cell mass. The glucose-stimulated insulin secretion (GSIS) in β cells is triggered by depolarization-evoked Ca2+ entry through voltage-gated Ca2+ (CaV) channels. The majority of CaV channels are believed to reside in cholesterol-rich membran

Parkinsons sjukdom (PS) är den näst vanligaste neurodegenerativa sjukdomen efter Alzheimers sjukdom och drabbar över 1 % av personer över 65 år. Även om denna progressiva och försvagande sjukdom brukar anses vara en motorsjukdom, med symtom som stelhet, långsamma rörelser och vilotremor, så påverkas också icke-motoriska funktioner som sömn, kognition och mag-tarmfunktion. Dessa symtom förekommer vParkinson’s disease (PD) is the second most common neurodegenerative disorder and affects over 1% of people above the age of 65. This progressive and debilitating disease is usually thought of as a motor disease, with symptoms such as muscle rigidity, slowness of movement, and tremor at rest.PD can be familial, where a single inherited gene mutation causes the disease, but most cases of PD (90%) a

Atmosfäriska partiklar (aerosoler) finns överallt i jordens atmosfär. Masskoncentrationen av dessa varierar kraftigt beroende på i vilken miljö man mäter. I stadsluft kan man uppmäta tiotals mikrogram per kubikmeter medan man i arktiska områden uppmäter nanogram per kubikmeter. Den kolhaltiga aerosolen utgör en betydande del av atmosfärsaerosolens massa och är känd för att påverka människors och dCarbonaceous aerosols are known to affect human health negatively and to affect the climate of Earth. As specific types of aerosols originate from specific sources, it is important to know the amount of aerosols emitted from each source. Aerosol source apportionment is an important tool in mitigating air pollution and improving air quality. The subject of this thesis was the evaluation and develop

IMPORTANCE Standard dosing of chemotherapy based on body surface area results in marked interpatient variation in pharmacokinetics, toxic effects, and efficacy.Whether tailored dosing can improve outcomes is unknown, as is the role of dose-dense adjuvant chemotherapy. OBJECTIVE To determine whether tailored dose-dense adjuvant chemotherapy improves the outcomes of early breast cancer compared with

Background: One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the age standardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are aff ecting the number of adults with d

ABSTRACTAs a part of a democratic demand for transparency in urban development processes it is important that design professionals hold the ability to scrutinise their own work process, and at certain stages let go of predefined ideas of future realities. This work revolves around how design professionals perceive options for design in such situations. A basic assumption in this work is that a des

Information and communication are increasingly being conveyed over the Internet. The forms of service and commerce that we are familiar with today will most likely be reduced in scale in the future to be replaced by new electronic solutions. For this reason, it is important that new technology be designed so that as many people as possible can utilize it. Accessibility to a range of services and i

Min forskningsfråga är i vilken utsträckning rätten till abort är skyddad i Europarådets system, med fokus på rättspraxis från den Europeiska domstolen för de mänskliga rättigheterna. Teorier och förklaringsmodeller som används för att analysera policybeslut, lagstiftning och rättsfall gällande abort i Europarådet presenteras först. I korthet menar dessa teorier att det finns en strukturell diskrMy research question is to what extent the right to abortion is protected in the Council of Europe system, with a focus on the case law of the European Court of Human Rights. First, theories and models of explanation are presented that are used to analyse the policies, legislation and cases on the issue abortion the Council of Europe. In short, these theories state that there is a structural disc

A wastewater treatment plant prediction in your computer The Källby wastewater treatment plant was set-up in a mathematical model reflecting its actual behaviour. Are the commonly available measurements good enough to perform a simulation? What kind of outcomes can we expect? After you have read the heading and the introduction, I guess that two proper questions swirling around in your head migh

Den här rapporten behandlar hur övertagande av huvudmannaskap för allmän plats i detaljplaner går till. I rapporten har det bland annat undersökts hur vanligt förekommande det är bland landets kommuner att arbeta med övertaganden. De bakomliggande skälen till varför kommunerna genomför övertaganden har också varit föremål för granskning, liksom enskilda väghållares utgångspunkter i frågan. Arbetet

In pursuit of a sustainable society, the bike possesses a central importance. It is important that the bike lanes meet the needs in terms of accessibility and safety. In the Netherlands, the UK and Denmark already exists so-called super cycle routes, which have proven to be very successful, as they contributed to the increased cycling, and at same time improved accessibility and comfort for the cy

Avtalsfrihet är en viktig princip i ett skiljeförfarande. Parterna kan genom avtal påverka handläggningen i skiljenämnden och konstruera regler som binder skiljemännen i bedömningen av deras tvist. Det finns dock begränsningar för avtalsfriheten, då förfarandet måste uppnå vissa rättssäkerhetsgarantier och parterna måste ha möjlighet att föra sin talan. Syftet med denna uppsats är att undersöka omFreedom of contract is an important principle in arbitration. The parties may by agreement affect the arbitration proceedings and construct procedural rules that bind the arbitrators in the assessment of their dispute. However, there are restrictions on the freedom of contract, since the procedure must attain certain procedural safeguards and the parties must have the opportunity to present their