In this report a generic model for the capture and assessment of end-user requirements and needs, the CREDIT carpenter model, has been developed. The main determinants of the model is the need for the project organisation (including the facilities management organisation) to ensure a thorough understanding of the end-user requirements and needs as well as an assessment through out the project proc

During south Scandinavian Late Bronze Age, c. 900-500 BC, a new tool was invented. It consisted of a wooden shaft and a knife blade made out of flint. One singel of this tool still exists today. It was found in a Danish bog in late 19th century. But there are many of the knife blades of flint; in museum collections or in flint assemblages from archaeological excavations. Archaeologists call them l

Changing Landscapes and Persistent Places is a study of the cultural landscape on the Bjäre peninsula in northwest Skåne. The many Bronze Age remains that give the landscape its distinctive character are the starting point for an attempt to increase our understanding of the historical depth of today’s landscape. The two perspectives of “landscape” and “places” carry the discussion forward, almost

Plants like all other eukaryotic organisms carry most of their DNA in the nucleus. In addition, plants also have both chloroplasts and mitochondria that contain their own genetic material. The genomes in chloroplasts and mitochondria control certain vital processes, but most often the organelles act under strict nuclear control. Usually the nuclear and organellar genomes live in "harmony", promoti

Parkinsons sjukdom (PS) är den näst vanligaste neurodegenerativa sjukdomen efter Alzheimers sjukdom och drabbar över 1 % av personer över 65 år. Även om denna progressiva och försvagande sjukdom brukar anses vara en motorsjukdom, med symtom som stelhet, långsamma rörelser och vilotremor, så påverkas också icke-motoriska funktioner som sömn, kognition och mag-tarmfunktion. Dessa symtom förekommer vParkinson’s disease (PD) is the second most common neurodegenerative disorder and affects over 1% of people above the age of 65. This progressive and debilitating disease is usually thought of as a motor disease, with symptoms such as muscle rigidity, slowness of movement, and tremor at rest.PD can be familial, where a single inherited gene mutation causes the disease, but most cases of PD (90%) a

Background: The pathological process in Alzheimer’s disease (AD) probably starts decades before the onset of symptoms and the clinical AD diagnosis. In patients with AD, the level of cerebrospinal fluid (CSF) amyloid-β1-42 (Aβ42) is usually lower, and the levels of total tau (T-tau) and phosphorylated tau (P-tau) higher than in healthy elderly people. However, the cutoffs differ between studies an

Background: The relationship between dyslipidemia, inflammation and CV organ damage in type 2 diabetes mellitus (T2DM) is complex. Insulin resistance and inflammatory cytokines interleukins (ILs) increase plasma triglycerides (TG). ILs also up-regulate expression of matrix-metalloproteinases (MMPs) that, together with TG, decrease high density lipoprotein cholesterol (HDL) levels. High TG, low HDL

It has been long known that hyperglycaemia-induced β-cell dysfunction precipitates type 2 diabetes (T2D) in insulin-resistant obesity, although the underlying mechanisms are still poorly defined. The few frequently used antidiabetic drugs on the market have still not satisfactorily demonstrated any long-lasting improvements of β-cell function and prevention of the disease. Islets synthesise and se

Information and communication are increasingly being conveyed over the Internet. The forms of service and commerce that we are familiar with today will most likely be reduced in scale in the future to be replaced by new electronic solutions. For this reason, it is important that new technology be designed so that as many people as possible can utilize it. Accessibility to a range of services and i

The study makes an inventory of learning opportunities young people were offered in connection with CEI 2016, one of the annual international conferences organized by the NGO named Caretakers of the Environment International (CEI), which year 2016 took place in Aalborg in Denmark. The learning opportunities offered by this transnational learning community are discussed in relation to some essentia

Windmill structures must withstand very high horizontal loading giving an extremely large overturning moment on the foundation. These structures have very low stability loads in comparison to the overturning loads. The traditional way to solve the construction problem uses a shallow foundation with a massive concrete volume or a piled foundation to resist the extreme overturning moment. This work

Hallmarks of type 2 diabetes (T2D) include elevated blood glucose and free fatty acids (FFAs) as a result of impaired β cell insulin secretion and decreased β cell mass. The glucose-stimulated insulin secretion (GSIS) in β cells is triggered by depolarization-evoked Ca2+ entry through voltage-gated Ca2+ (CaV) channels. The majority of CaV channels are believed to reside in cholesterol-rich membran

It has often been argued that money and modern monetary economies have occasioned a comprehensive rationalisation of society. Money has often been viewed as being socially destructive, while it is said that the modern monetary economy has had inescapable consequences for society, culture, and people’s daily lives. This thesis considers the introduction of computerised systems for handling digital